Neuroscience and Neuropharmacology Research

Perineuronal nets in the bed nucleus of stria terminalis mediate stress-induced anxiety behaviour in adult male mice

This study shows that perineuronal nets in the anteromedial BNST regulate stress-induced anxiety in adult male mice by modulating synaptic plasticity and emotional responses to stress.

Long-Term Reconfiguration of Dynamic Polarization and Action Potential Initiation in Purkinje Cell Axons

The paper shows that in Purkinje cells, action potential initiation shifts from the soma to axon terminals following dendritic plasticity, indicating dynamic axonal plasticity and local computation.

Dendritic turnover zones support switching between rules without expanding the cortical engram

The paper investigates how dendritic turnover zones in the secondary motor cortex support rule switching without expanding the cortical engram by analyzing spine dynamics and modeling synaptic reorganization.

Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

Decoupling of spontaneous and evoked activity in locus coeruleus neurons: early synaptic and ion-channel remodeling in a mouse model of Alzheimer's disease

This study identifies synaptic and ion-channel remodeling in locus coeruleus neurons of young 3xTg mice, leading to decoupling of spontaneous and evoked activity in a mouse model of Alzheimer's disease.

Co-option of CENP-A for activity-induced neuronal plasticity

This study shows that CENP-A, a centromere-specific histone variant, is dynamically regulated by synaptic activity in neurons and is required for activity-dependent gene expression and hippocampus-dependent learning and memory.

Dizocilpine-derived K2060 exhibits enhanced blockage at NMDA receptors with impaired Mg2+ block and provides strong protection against audiogenic seizures

This study evaluates how impaired Mg2+ block at NMDA receptors affects the efficacy of K2060, memantine, and ketamine in protecting against audiogenic seizures.

Clustering of the Adhesion-GPCR Latrophilin-3 Drives Excitatory Synapse Assembly

The paper identifies nanoscale clustering of Latrophilin-3 as a mechanism driving excitatory synapse assembly, showing that clustering, not ligand binding, is critical for synapse formation.

Adaptive co-transmission shapes sensory encoding and behavior

The paper shows that coexisting neurotransmitters in C. elegans are differentially regulated by experience and contribute distinctively to behavior.

Synaptic vesicle undocking induces low frequency depression

The paper investigates low frequency depression (LFD) in synapses and finds it results from synaptic vesicle undocking rather than depletion of the readily releasable pool.

Large-scale all-optical electrophysiology links excitability and connectivity to circuit dynamics in vivo

The paper develops tools for large-scale all-optical electrophysiology to study neural circuit dynamics, excitability, and connectivity in vivo.

An astrocytic AMPAR-dependent parity signal preserves synaptic strength

The paper shows that astrocytic AMPAR inhibition in mouse striatal projection neurons converts glutamatergic activity into long-term depression, suggesting astrocytic glutamate sensing stabilizes synaptic strength.

Recruitment of the local GABAergic population engages complex network interactions in the ventral subiculum

The paper investigates the functional consequences of recruiting the local GABAergic population in the ventral subiculum using optogenetic stimulation and electrophysiological recordings in rats.

Plasticity-induced actin polymerization positions endocytic compartments at the bases of stimulated spines

The paper shows that actin polymerization in dendritic shafts positions endocytic compartments at stimulated spine bases, enhancing glutamate receptor turnover and spine enlargement.

WTR: A Toolkit for Functional Anterograde Transneuronal Circuit Mapping

WTR is a toolkit for functional anterograde transneuronal circuit mapping using a fusion protein that labels and manipulates downstream neurons.

Cell-intrinsic regulation of presynaptic release site patterning

The paper identifies SYG-1 and SYG-2 as cell-autonomous regulators of presynaptic release-site patterning in C. elegans DA9 motor neurons.

Clustered and diffuse sensory corticostriatal wirings define complementary interneuron circuits

The paper investigates corticostriatal connectivity differences between PV and SOM interneurons and SPN, finding distinct spatial and population-level features.

Distinct protein synthesis requirements for coupled excitatory and inhibitory long-term co-plasticity in mouse hippocampus

This study investigates the role of protein synthesis in excitatory and inhibitory long-term plasticity in mouse hippocampus, finding distinct translational mechanisms for each.

Alcohol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens

This study shows that ethanol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the nucleus accumbens, with effects persisting during early abstinence.

Synapse-like Specializations at Dopamine Release Sites Orchestrate Efficient and Precise Neuromodulatory Signaling

This paper reveals that dopamine release is highly localized to synapse-like structures, challenging the idea that neuromodulators act diffusely.

A Normative Model Reveals Functional Optimization of Synaptic Nano-Architecture

The paper develops a normative model to show that transsynaptic nano-architecture optimizes postsynaptic current amplitude and minimizes delay during multivesicular release at the Drosophila NMJ.

Repeated swim exposure and PKN1a knockout enhance group I mGluR-dependent excitability associated with reduced EAAT3 expression in mouse dentate granule cells

This study shows that repeated swim exposure and PKN1a knockout increase excitability in mouse dentate granule cells by reducing EAAT3 expression and mGluR activity, while also decreasing anxiety-like behavior.

Embryonic depletion of D-aspartate perturbs NMDA receptor-dependent long-term potentiation in the hippocampus of juvenile mice

This study shows that embryonic depletion of D-aspartate in mice leads to increased NMDA receptor-dependent long-term potentiation in juvenile hippocampus, which is reversible with exogenous D-aspartate.

Acute ClC-2 blockade increases neuronal intracellular chloride and depolarizes EGABA

This study shows that acute ClC-2 inhibition depolarizes EGABA, increases neuronal intracellular chloride, and alters GABAergic chloride signaling dynamics.

A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis

This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.

Structural basis of GABA transport by the vesicular inhibitory amino acid transporter VIAAT

This study determines the cryo-EM structures of human VIAAT in different states to elucidate its mechanism of GABA transport and how mutations affect inhibitory neurotransmission.

Sequential maturation of supramammillary glutamatergic/GABAergic co-transmission onto adult-born dentate granule cells

This study shows that synapses from the supramammillary nucleus onto adult-born dentate granule cells mature from GABAergic to glutamate/GABA co-transmission, with SuM activity promoting this transition.

Discovery of the Honeycomb Synapse in Spinal Motor Circuits

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

Bassoon is required for adult ocular dominance plasticity and experience-induced changes in synapsin phosphorylation in visual cortex

This study shows that bassoon is essential for adult ocular dominance plasticity but not juvenile plasticity, involving presynaptic changes in synapsin phosphorylation.

Cell surface markers identify astrocyte subpopulations in the adult hippocampus with a heterogeneous response to aging

The paper identifies astrocyte subpopulations in the adult hippocampus based on cell surface markers and shows their distinct transcriptomic responses to aging.