Hepatitis B Virus Studies

Snake Kolmiovirus Encodes a Single Form of Delta Antigen and Shows No Evidence of Translation from Open Reading Frame 2

This study investigates the protein expression of Swiss snake colony virus 1 (SwSCV-1) and finds it encodes only a single form of the delta antigen, unlike hepatitis D virus (HDV), and the additional ORF2 does not produce a functional protein.

Spiperone targets HBV cccDNA via ER stress induced innate immune activation and epigenetic silencing

This study identifies Spiperone as a repurposed drug that reduces HBV cccDNA through ER stress and epigenetic mechanisms, showing synergistic effects with tenofovir.

Evaluation of a multiplexed tiling PCR scheme for whole-genome amplification of hepatitis B virus using Oxford Nanopore sequencing

The paper evaluates a tiling PCR primer scheme for HBV whole-genome amplification using Oxford Nanopore sequencing, finding uneven amplicon performance limits full-genome recovery.

Involvement of Hepatitis B Core-Related Antigen in Viral Genome Integration in Patients With Prior Hepatitis B Virus Infection

The study investigates HBV genome integration in HBcAb-positive NBNC-HCC patients and finds HBV integration near TERT, KMT2B, and LOC441666, with HBcrAg as a potential marker for HBV detection.

Ritonavir-Induced Cellular Stress Alters Viral HBs Glycoprotein Biogenesis and Production of Infectious Hepatitis D Virions

This paper shows ritonavir and other cytochrome P450 inhibitors reduce infectious HDV virion production by inducing oxidative stress and disrupting HBs glycoprotein biogenesis in human hepatocytes.

Deltaviruses spread through a viral Trojan Horse

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

Identification of molecular determinants governing KIF4 cargo recognition of NTCP and their role in HBV/HDV infection

The paper identifies a leucine-rich motif in NTCP essential for KIF4-mediated trafficking and HBV/HDV infection, revealing a conserved cargo recognition mechanism shared with integrin β1.

ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencing

This study identifies ZNF638 as a host factor that represses HBV transcription by recruiting the HUSH complex to induce H3K9me3 histone modifications, thereby silencing cccDNA and reducing viral propagation.

Mechanistic insights into CAM-induced disruption of HBV capsids revealed by all-atom MD simulations

This paper uses all-atom MD simulations to show how CAMs alter HBV capsid structure by inducing strain propagation and morphological changes through interdimer interfaces.

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

Disruption of the NTCP-EGFR receptor complex as a strategy for selective inhibition of hepatitis B and D virus entry

This study identifies Oxy229, a compound that disrupts the NTCP-EGFR receptor complex, selectively inhibiting HBV and HDV entry without affecting NTCP or EGFR physiological functions.

PreS1-decorated recombinant adenovirus encoding HBV antigens generates neutralizing humoral and cellular immunity

This study develops a vaccine using PreS1-decorated adenovirus that induces neutralizing antibodies and T-cell responses against HBV and HDV.

DNA synthesis inside the hepatitis B virus creates a high-energy spool

The paper determines the structures of mature HBV and Duck HBV, revealing that DNA forms a spool within the capsid that interacts with interior charges and creates a metastable state for genome uncoating.

Decoding the interconnected splicing patterns of hepatitis B virus and host using large language and deep learning models

This paper uses AI to analyze HBV splicing patterns and shows that splicing efficiency correlates with disease severity, revealing similarities between HBV and host splice sites.

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

The histone variant H2A.Z and its chaperone SRCAP are required for RNA polymerase II to access HBV chromatin

This study identifies H2A.Z and SRCAP as essential for HBV cccDNA transcription by promoting chromatin accessibility and RNA polymerase II recruitment.

Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4+ T cell responses

The paper identifies shared mechanisms of HBsAg seroclearance using a mouse model and longitudinal PBMCs from CHB patients, showing CD4+ T cell activation is essential for clinical cure.

PD-1 signaling is essential for the early accumulation of HBV-specific CD8+ T cells during HBV infection

This study shows PD-1 is essential for early HBV-specific CD8+ T cell expansion and survival during acute infection but does not suppress effector cytokine function, and its absence impairs proliferation and promotes exhaustion in chronic infection.

Proteomic Signatures of Hepatitis B Virus Mutations Reveal Genotype-Specific Host Responses and Biomarker Candidates

The paper uses proteomics to analyze HBV-infected patient serum samples, identifying genotype-specific proteomic signatures and potential biomarkers.

Modeling of hepatitis B virus infection spread in primary human hepatocytes

The paper models HBV infection spread in primary human hepatocytes using agent-based modeling, identifying viral kinetic patterns and estimating the efficacy of an entry inhibitor.

Genotypic Diversity of Hepatitis B and Delta Viruses in Peru: A Phylogenetic Study Using Next-Generation Sequencing.

This study uses next-generation sequencing to analyze HBV and HDV genotypes and mutations in Peruvian samples, identifying genotype F for HBV and genotype 3 for HDV with associated clinical mutations.

Conserved yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X Proteins

This study investigates whether the DCHBV X protein, like HBV X, degrades the Smc5/6 complex and finds it does so in multiple host species with varying efficiency and independently of DDB1.

Temporal foundation model unveils ancient HepatitisB virus evolution

This paper develops ViraChron, a temporal foundation model for HBV evolution, enabling accurate sequence completion and analysis of ancient HBV genomes.

mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models

This study shows mRNA-LNP vaccines against HBV induce strong immune responses in both preventive and chronic infection models in mice.

RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.

This study identifies S169, an RXR agonist, as an inhibitor of HBV/HDV entry by disrupting KIF4-dependent NTCP trafficking in human hepatocytes.

A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B

The paper develops a multiscale model of CAM treatment in chronic HBV infection, showing HBV RNA is more sensitive to CAM effectiveness than HBV DNA.

Presence of Hepatitis B virus infection in colon cancer

This study investigates HBV infection in colon cancer patients, finding HBsAg in colonic cells and immune cells, with higher infection rates in tumors.

Genetic Susceptibility of Saudi Population to Hepatitis B Virus (HBV) Infection and the Predicted Functional Consequences

The paper analyzes HBV-associated SNPs in the Saudi population, predicts their functional impact, and suggests future directions for HBV research.

A Single-Cell Woodchuck Liver Atlas Identifies Healthy and Disease-Related Cellular Programs Conserved in Human

This paper creates a single-cell atlas of the woodchuck liver to identify cellular programs in health and disease, showing similarities with human HBV infection.

Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFN non-response

This study finds that auto-antibodies against interferons are common in chronic hepatitis B patients and linked to PegIFN treatment non-response.