Neurogenesis and neuroplasticity mechanisms

Motor Learning Drives Dynamic Patterns of Intermittent Myelination onLearning-Activated Axons

The paper shows that learning induces dynamic changes in myelination on specific axons, altering conduction speed and correlating with behavioral improvement.

Hippocampal Transplants of Fetal GABAergic Progenitors Regulate Adult Neurogenesis in Mice with Temporal Lobe Epilepsy

This study shows that transplanting fetal GABAergic progenitors into mice with temporal lobe epilepsy reduces seizure frequency by correcting abnormalities in adult neurogenesis.

Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype

This study shows that lesion environments direct transplanted neural progenitors to differentiate into neuroprotective astroglial cells in CNS injuries.

HB-EGF promotes horizontal basal cell proliferation and olfactory sensory neuron regeneration in the zebrafish olfactory epithelium

This study shows HB-EGF promotes HBC expansion and OSN regeneration in zebrafish OE after injury, while inhibiting HB-EGF/EGFR signaling delays repair.

Heterogeneity in the size of the apical surface of cortical progenitors

The paper shows apical progenitors in the developing neocortex have heterogeneous apical surface areas, and Ephrin B1 regulates this size without affecting proliferation or differentiation.

Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence

The paper identifies a previously unknown region in the mouse amygdala containing immature excitatory neurons that mature during adolescence and migrate into the endopiriform cortex, similar to human paralaminar neurons.

CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

This study identifies VAMP2/3-mediated exocytosis as essential for CNS myelin membrane expansion, revealing a pathway critical for myelin formation and potential therapeutic targeting.

7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

This study shows that DHCR7 deficiency leads to oxysterol accumulation, causing premature neurogenesis and neuronal localization issues in SLOS, with GR as a potential therapeutic target.

Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination

This study shows that ATRX loss in oligodendrocyte progenitor cells causes myelination deficits and promotes astrocyte-like features, highlighting ATRX's role in myelination and glial cell fate.

Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle

This study shows that CHD8 haploinsufficiency in human neural progenitors shortens the G1 phase of the cell cycle, leading to increased proliferation and potential macrocephaly in autism.

Genetic loss of norepinephrine does not alter adult hippocampal neurogenesis in dopamine β-hydroxylase deficient mice

The paper investigates the effect of genetic NE loss on adult hippocampal neurogenesis and finds no difference in progenitor proliferation or survival in Dbh-/- mice, contrasting with pharmacological NE depletion.

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

Human Adult Neurogenesis Loss Underlies Cognitive Decline During Epilepsy Progression

The paper shows that adult neurogenesis loss in MTLE patients correlates with cognitive decline, particularly in verbal learning and memory after 20 years of disease duration.

Regulation of oligodendrocyte lineage development by VAMP2/3 in the developing mouse spinal cord

This study shows that VAMP2/3 SNARE proteins are essential for premyelinating oligodendrocyte maturation and myelin formation in the developing mouse spinal cord.

Heterogeneous migration of neuronal progenitors to the insula shapes the human brain

The paper shows that the insula develops through curved migration of progenitor cells due to obstruction by lenticular nuclei, challenging existing radial migration models.

Self-assembly of cellular neighborhoods converts stochastic signaling into sustained olfactory neurogenesis

The paper shows that stochastic signaling is converted into sustained olfactory neurogenesis through spatially restricted self-assembly of progenitor cell neighborhoods in zebrafish.

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors

The paper identifies species-specific transposon-derived enhancers contributing to transcriptomic differences in human and chimpanzee hippocampal intermediate progenitors.

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

This study shows norepinephrine modulates OPC calcium dynamics and lineage progression in vivo through adrenergic signaling.

Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis

This study shows that activating the M4 muscarinic receptor in quiescent neural precursor cells enhances adult hippocampal neurogenesis and rescues impairments caused by cholinergic neuron loss.

Temporal origin of mouse claustrum and development of its cortical projections

This study determines the developmental timeline of the mouse claustrum, including neuronal birthdates, spatial localization, and the maturation of its cortical projections.

Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis

The paper shows that hippocampal network dynamics in adult mice are shaped by the birthdate and rate of neurogenesis during embryonic development.

16p11.2 locus decelerates subpallial maturation and limits variability in human iPSC-derived ventral telencephalic organoids

The paper shows that 16p11.2 microdeletions increase developmental variability and prolong the cell cycle of human subpallial progenitors by lengthening their G1 phase in organoids.

3D reconstruction of the cerebellar germinal layer reveals intercytoplasmic connections between developing granule cells

The paper uses 3D reconstruction and deep learning to reveal intercellular connections between developing granule cells in the cerebellar EGL, showing a continuum of proliferative and migratory events.

Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging

This study identifies age-related lipidomic changes in neural stem cells using mass spectrometry and shows that lipid modifications affect NSC function and activation.

Neuroblast migration along cellular substrates in the developing porcine brain

The paper investigates neuroblast migration in porcine brain development, focusing on their association with cellular substrates during key developmental stages.

Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models

This study shows that reducing PTBP1 in astrocytes does not convert them into neurons or improve Alzheimer's symptoms in mouse models.

p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation

This study identifies p75NTR as an anti-migratory factor in cerebellar granule cell precursors by maintaining active RhoA levels during proliferation.

ADAMTS2 regulates radial neuronal migration by activating TGF-β signaling at the subplate layer of the developing neocortex

This study identifies ADAMTS2 as a key regulator of radial neuronal migration by activating TGF-β signaling through ECM remodeling at the subplate layer during neuronal development.

Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons

This study investigates the role of ERK1/2 signaling in the development of MGE-derived glia and cortical inhibitory neurons, showing its necessity for glial number and activity-dependent responses in neurons.

Single-cell transcriptome analysis reveals heterogeneity and a dynamic regenerative response of quiescent radial glia in adult zebrafish brain

The paper uses single-cell transcriptomics to identify heterogeneity in quiescent radial glia and shows their dynamic regenerative response to brain damage in adult zebrafish.