Neurogenesis and neuroplasticity mechanisms

Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous ECM

This study compares the effects of exogenous and endogenous ECM on neuroepithelial development in human telencephalic organoids, showing rapid polarization with exogenous ECM and gradual acquisition with endogenous ECM.

The piRNA pathway sustains adult neurogenesis by repressing protein synthesis and cellular senescence

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.

mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

This study shows that deleting mTORC2 in oligodendrocyte progenitor cells causes hypomyelination specifically in the corpus callosum, but not the spinal cord.

Growth/differentiation factor 15 controls number of ependymal and neural stem cells in the ventricular-subventricular zone

This study shows that GDF15 regulates proliferation of apical progenitors in the developing murine ganglionic eminence, increasing ependymal cells and neural stem cells.

Low-efficiency conversion of proliferative glia into induced neurons by Ascl1 in the postnatal mouse cerebral cortex in vivo

This study shows that Ascl1 induces low-efficiency neuronal reprogramming of proliferative glia in vivo, unlike its efficient in vitro conversion.

miR-17~92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages

This study shows miR-17~92 has different effects on neural stem cells and transit amplifying cells in the adult mouse V-SVZ, affecting proliferation and lineage commitment.

Binucleated cells generated by nuclear movement during neural transdifferentiation from human bone marrow-derived mesenchymal cells

This study shows human bone marrow-derived mesenchymal cells can transdifferentiate into neural-like cells without cell fusion, forming binucleated cells through nuclear movement.

Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains

This study compares phenotypes of Pax6 mutant cerebral organoids with Pax6 mutant mouse embryos, finding similarities in neural differentiation and cell cycle changes.

Anatomical development of the cerebellothalamic tract in embryonic mice

This paper investigates the anatomical development of the cerebello-thalamic tract in embryonic mice, showing that axons invade the thalamus after E16.5 and establish synapses by E18.5.

Stemness activity underlying whole brain regeneration in a basal chordate

This study characterizes the transcriptomic and cellular dynamics of whole CNS regeneration in the tunicate Polycarpa mytiligera, identifying key pathways and markers involved in the process.

Subcellular proteome of radial glia reveals non-muscle myosins control basal endfeet to mediate interneuron organization

The paper uses in vivo proximity labeling to analyze the subcellular proteome of radial glial cells and identifies non-muscle myosins that regulate endfoot structure and interneuron organization.

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

Learning-related contraction of grey matter in rodent sensorimotor cortex is associated with adaptive myelination

The paper investigates learning-related changes in grey matter and myelin in rodent sensorimotor cortex using MRI and immunohistochemistry, finding non-linear morphometric changes linked to myelin plasticity.

Cephalopod Retinal Development Shows Vertebrate-like Mechanisms of Neurogenesis

The paper uses live-imaging to show that squid retinal neurogenesis shares vertebrate-like mechanisms, including interkinetic nuclear migration and Notch signaling regulation.

Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

GABAergic regulation of cell proliferation within the adult mouse spinal cord

The paper shows that GABA levels in the adult mouse spinal cord regulate neural stem cell proliferation, with increased GABA reducing proliferation and decreased GABA increasing it.

Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures

The paper shows that seizures in mice disrupt the hippocampal neurogenic niche by inducing reactive neural stem cells via the EGFR pathway, and inhibiting EGFR improves neurogenesis.

Cut homeodomain transcription factor is a novel regulator of cortex glia morphogenesis and maintenance of neural niche

The paper identifies Cut as a regulator of cortex glia growth and endomitosis in Drosophila, impacting neural niche formation and function.

Zic3 enables bimodal regulation of tyrosine hydroxylase expression in dopaminergic neurons of olfactory bulb and midbrain

This study identifies ZIC3 as a key regulator of tyrosine hydroxylase expression in dopaminergic neurons of the olfactory bulb and midbrain through dual regulatory mechanisms.

Brain injuries and complex motor learning suppress Olig2 in a subpopulation of oligodendrocyte precursor cells

The paper identifies a subset of oligodendrocyte precursor cells (OPCs) that lack Olig2 expression, which is influenced by brain injuries and complex motor learning.

Granule cells affect dendritic tree selection in purkinje cells during cerebellar development

This paper develops a computational model to study how granule cell interactions influence dendritic tree selection in Purkinje cells during cerebellar development.

MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain

The paper investigates MYT1L's role in suppressing earlier neuronal development programs in the adult mouse brain, showing it regulates gene expression and chromatin structure in cortical neurons.

Foxp1 acts upstream of Vegfa, suppresses cortical angiogenesis, and promotes hypoxia in radial glia.

This study shows that Foxp1 loss increases angiogenesis and hypoxia in radial glia, altering their metabolic state and neurogenic capacity.

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

The paper identifies SHH signaling from retinal ganglion cells to thalamic astrocytes as essential for GABAergic interneuron migration into the visual thalamus.

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

This study identifies Tensin3 as a critical regulator of oligodendrocyte differentiation by mediating integrin-β1 survival signaling during morphological changes.

Signal integration by a bHLH circuit enables fate choice in neural stem cells

The paper shows that a bHLH circuit enables neural stem cells to choose astrocytic fate by integrating BMP and LIF signals and suppressing alternative fates.

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes

This study develops a method to generate cortico-striatal organoids from single neural rosettes to model SHANK3 deficiency in autism and intellectual disability.

Dentate gyrus morphogenesis is regulated by β-CATENIN function in hem-derived fimbrial glia.

This study shows that β-CATENIN is essential for organizing fimbrial glia and guiding dentate gyrus development, but not for CR cell positioning.

A corset of adhesions during development establishes individual neural stem cell niches and controls adult behaviour

The paper identifies adhesion mechanisms that form individual neural stem cell niches in Drosophila and links their disruption to altered adult behavior.