Neurogenesis and neuroplasticity mechanisms

Cell cycle and temporal transcription factors regulate proliferation and neuronal diversity of dedifferentiation-derived neural stem cells

This study shows that dedifferentiation-derived neural stem cells (NSCs) fail to express late temporal transcription factors, leading to impaired neuronal diversity and cell cycle progression.

Sensory deprivation triggers phenotypic adjustment of dopaminergic interneurons in the mouse olfactory bulb

The paper shows that sensory deprivation causes GABAergic interneurons to die while dopaminergic neurons adapt by reducing tyrosine hydroxylase expression in mice.

Enhancers of human and rodent oligodendrocyte formation predominantly induce cholesterol precursor accumulation

This study identifies that many molecules promoting oligodendrocyte formation inhibit cholesterol pathway enzymes, with a focus on EBP, and proposes a model for their mechanism.

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of amidbrain GABAergic neuron subtype with characteristics of REM sleep regulatory neurons

The paper identifies a transcription factor network involving Gata2, Nkx2-2, and Skor2 that regulates the development of midbrain GABAergic neurons associated with REM sleep regulation.

Human neural progenitors establish a diffusion barrier in the ER membrane during cell division

The paper shows human neural progenitors form an ER diffusion barrier during cell division, enabling asymmetric segregation of damaged proteins.

Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling

This study identifies Dbx1 as a regulator of astrocyte development in the mouse spinal cord by modulating Notch signaling and influencing neuron-glial balance.

Human-specific progenitor sub-domain contributes to extended neurogenesis and increased motor neuron production

The paper identifies a human-specific progenitor sub-domain in the spinal cord that extends neurogenesis and increases motor neuron production compared to mice.

Enhancing NeuroD1 Expression to Convert Lineage-Traced Astrocytes into Neurons

This study shows that enhancing NeuroD1 expression can convert astrocytes into neurons in mice, but lineage-traced astrocytes require stronger conversion signals.

Morphological pseudotime ordering and fate mapping reveals diversification of cerebellar inhibitory interneurons

The paper uses morphology-based pseudotime and fate mapping to show cerebellar inhibitory interneurons diversify into two classes with within-class heterogeneity.

SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia.

The paper investigates SOX10 expression levels in schizophrenia and finds reduced SOX10 correlates with oligodendrocyte dysfunction and impaired white matter.

Subventricular zone cytogenesis provides trophic support for neural repair

This study shows that post-stroke SVZ-derived cells provide trophic support for neural repair rather than replacing damaged cells, with VEGF playing a key role in recovery.

Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory

This study shows that disrupting BCAA metabolism in the nervous system impairs hippocampal neurogenesis and working memory in mice.

Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease

The paper uses single-cell RNA-Seq to study neural stem cell (NSC) defects in 3xTG-AD mice, finding reduced NSC activation and impaired neurogenesis linked to AD pathology.

Cd59 and inflammation orchestrate Schwann cell development

This study identifies Cd59 and inflammation as critical for Schwann cell development, showing that Cd59 deficiency leads to myelin defects and that inflammation inhibition restores normal development.

Human Cerebral Spheroids Undergo Activity Dependent Changes In Cellular Composition And MicroRNA Expression

The paper shows that increasing neuronal activity in human cerebral spheroids increases new neurons and decreases new glial cells, with reduced miR-135a expression.

Computational Identification of Ligand-Receptor Pairs that Drive Human Astrocyte Development

The paper identifies and validates synergistic ligand-receptor pairs that drive astrocyte development in the human brain using computational methods and experimental testing.

Amoeboid-like neuronal migration ensures correct horizontal cell layer formation in the developing vertebrate retina

The paper shows that horizontal cells in the zebrafish retina use amoeboid-like migration to navigate crowded tissue and form the correct layer.

Altered patterning of interneuron progenitors in Down syndrome

This study identifies reduced WNT signaling in Down syndrome progenitors, leading to fewer COUP-TFII+ interneurons and impaired neurogenesis.

Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

Basal forebrain cholinergic circuits orchestrate diverse cell types in the adult dentate gyrus to support neural stem cell function and spatial memory

This study identifies cholinergic circuits that regulate neural stem cell function and spatial memory by orchestrating diverse cell types in the dentate gyrus through transcriptomic and functional analyses.

The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus.

This study shows that Lmo3 is required for the development of specific GPe neuronal subtypes and their connectivity in the basal ganglia.

Spatial cell type mapping of the oligodendrocyte lineage in the mouse juvenile and adult CNS with in situ sequencing

This study uses in situ sequencing to map oligodendrocyte lineage progression across brain and spinal cord regions in juvenile and adult mice, revealing spatial and temporal heterogeneity.

Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

This study identifies six signaling pathways regulating the proliferation and developmental potential of human neuroepithelial stem cells in vitro.

Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling

The paper uses single-cell RNA-sequencing to identify quiescent neural stem cells in the dorsal V-SVZ and shows that TGFbeta/BMP signalling drives their quiescence and blocks glutamatergic neurogenesis.

Dendritic inhibition by Shh signaling-dependent stellate cell pool is critical for motor learning

This study shows that Shh signaling regulates stellate cell pool size in the cerebellum, which is critical for dendritic inhibition and motor learning.

Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development

This study investigates how mechanical and chemical cues influence the migration of Cajal-Retzius cells in the developing neocortex, showing that mechanical properties and route stiffness affect their distribution.

Dandy Walker-like malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development

The paper shows that PDGF-C/PDGFRα signaling is critical for cerebellar development, as its loss in mice causes hypoplasia, malformation, and ependymal denudation.

Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

This study shows that persistent Cajal-Retzius cells in the postnatal hippocampus are essential for the development of dendritic spines in CA1 pyramidal cells.

Tle4 controls both developmental acquisition and postnatal maintenance of corticothalamic projection neuron identity

This study identifies Tle4's role in both the acquisition and maintenance of corticothalamic projection neuron identity through epigenetic regulation of Fezf2 expression.

Input-specific control of interneuron numbers in nascent striatal networks

The paper identifies input-specific mechanisms regulating the survival of two striatal interneuron subtypes during programmed cell death.