Genetics, Aging, and Longevity in Model Organisms

Microbiome contribution to Indy longevity in Drosophila

This study shows that reducing Indy gene activity in Drosophila lowers bacterial load and preserves gut homeostasis, extending lifespan through JAK/STAT signaling pathway modulation.

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila.

This study shows that age-dependent H3K9 trimethylation by dSetdb1 impairs UPRMT in Drosophila olfactory neurons, leading to neurodegeneration and loss of olfactory function, which can be reversed by dSetdb1 knockdown.

Mild Mitochondrial Impairment Activates Overlapping Longevity Pathways Converging on the Flavin-Containing Monooxygenase FMO-2

This study identifies FMO-2 as a downstream effector of multiple longevity pathways in C. elegans mitochondrial mutants, showing its requirement for lifespan extension.

Integrating supervised and unsupervised machine learning for behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred mice

The paper combines supervised and unsupervised machine learning to improve aging predictions in mice by identifying latent frailty signatures.

Selective activation of IRE-1 safeguards restoration of translation and organismal rejuvenation from adult reproductive diapause

This study shows that refeeding reverses aging-like phenotypes in C. elegans reproductive diapause by selectively activating the IRE-1 branch of UPRER and enhancing protein synthesis and folding.

The Cepeda Framework: A Modular, Safety-First Preclinical Architecture for Testing Coordinated Multi-Hallmark Rejuvenation Hypotheses in Biological Aging

The paper introduces the Cepeda Framework, a computational preclinical model testing coordinated rejuvenation strategies across 12 aging hallmarks using safety-gated simulations.

Avoidance Of Rejuvenation: A Stress Test For Evolutionary Theories Of Aging

This paper challenges classic evolutionary theories of aging by showing that rejuvenation's avoidance in nature contradicts these theories, suggesting an alternative adaptive framework.

A high-throughput cost-efficient in vitro platform for the screening of immune senomodulators

The paper develops an in vitro platform to screen immune senomodulators using human-derived immune cells, enabling personalized anti-aging treatments through multi-scale molecular analysis.

Testing the redox theory of aging under parasitism

This study tests the redox theory of aging by evolving mosquitoes under different reproductive schedules and parasite exposure, finding that oxidative stress contributes but does not determine aging.

SIN3 Regulates Transcriptional and Longevity Responses to Glycolytic Perturbation in Drosophila melanogaster

This study shows SIN3 regulates glycolytic gene expression and lifespan in Drosophila under metabolic stress, acting as a metabolic sensor and linking transcription to organismal adaptation.

Validation of tissue-specific RNAi systems in C. elegans reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespan

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress

The paper shows that GCY-9 in C. elegans carbon dioxide sensing neurons primes mitochondrial stress response to enhance metabolic resilience under starvation.

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

A hierarchy of causes of death in senescent C. elegans

The paper shows that in C. elegans, lifespan is limited by competing senescent pathologies, and removing one can unmask another, indicating lifespan extension may not reflect reduced aging rate.

A flexible diet platform for the nutrigenomic screening of Drosophila disease models

The paper develops a flexible diet platform for nutrigenomic screening in Drosophila disease models, showing it can identify nutrient-specific effects on disease phenotypes.

Mid-infrared light produces anti-ageing effects through resonant absorption by living organisms

This study shows that mid-infrared light at 34 THz extends the lifespan of C. elegans by 60% through enhancing cellular efficiency, not by thermal effects or stress response activation.

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling

The paper uses yeast aging to map proteome changes across age, revealing structural determinants of age-sensitive remodeling and providing a resource for aging research.

Single-Cell Spatial Proteomics Uncovers Molecular Interconnectivity among Hallmarks of Aging

The paper uses single-cell spatial proteomics in yeast to uncover molecular changes linked to aging hallmarks and their spatial organization.

Parallel adaptive responses to postponed reproduction increase lifespan and immune defense

This study shows that selecting Drosophila for postponed reproduction increases lifespan and immune defense, with convergent genetic changes across populations.

Short-Term Performance Assay Identifies Functional Benefits and Early Toxicity of Longevity Interventions in Mice

This paper presents a short-term performance assay in mice to evaluate functional benefits and early toxicity of anti-aging interventions, identifying compound-specific effects and highlighting potential toxicity.

Modulation of the RNAse P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans

This study identifies new regulators of heat hormesis in C. elegans through transcriptomic and chromatin accessibility analysis, revealing tissue-specific responses and conserved factors involved in stress resilience and longevity.

Induction and regulation of a reversible form of suspended animation in C. elegans

The paper describes a reversible form of suspended animation in C. elegans induced by high population density and identifies molecular mechanisms regulating its induction and termination.

Longitudinal dynamics of organ-specific proteomic aging clocks over a decade of midlife

This study evaluates the longitudinal behavior of organ-specific proteomic aging clocks over a decade, finding stability in age acceleration and links to subclinical risk factors and menopause in women.

Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging

This study identifies retrotransposon dynamics and chromatin regulation as key mechanisms by which metformin extends lifespan in yeast.

Genetic regulation of fasting-induced longevity effects

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan

The paper tests pro-longevity compounds on C. elegans males, finding lifespan extension in all tested conditions but only two compounds improved reproductive healthspan.

Metabolic state modulates risky foraging behavior via multiple branches of the insulin/IGF-1-like pathway in C. elegans

This study identifies DAF-2 as a key modulator of risky foraging behavior in C. elegans under food deprivation and shows multiple downstream pathways, including DAF-16 and CASY-1, are involved.

Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan

This study shows that cell enlargement drives proteome remodeling and shortens replicative lifespan in yeast, independent of known aging factors.