Genetics, Aging, and Longevity in Model Organisms

ORANGE: A Machine Learning Approach for Modeling Tissue-Specific Aging from Transcriptomic Data

This paper models tissue-specific biological age using machine learning on GTEx data, finding that extreme aging in specific tissues correlates with increased mortality risk.

Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing.

This study shows that intestinal immune activation and barrier loss have distinct effects on microbiota and mortality in Drosophila, independent of each other.

Thermodynamic scaling of canine aging and reversible clock deceleration by a reverse transcriptase inhibitor

The paper tracks aging in sled dogs using a variational autoregressive model to show that lamivudine temporarily decelerates DNA methylation clocks but not long-term biological age.

Cdc42 Partitioning by Chaperone Ydj1 During Asymmetric Division and Aging in Yeast

The paper shows that Cdc42 accumulates in yeast mother cells over time, and Ydj1 helps distribute it unevenly to daughter cells, reducing aging in daughters.

Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

The paper uses plasma proteomics to estimate biological age of multiple cell types and links aging signatures to disease risk and mortality across 60,000 individuals.

Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation in Nothobranchius furzeri.

This study shows that intermittent fasting improves muscle health and extends lifespan in both sexes of African turquoise killifish, with sex-specific molecular and cellular changes.

Convergent molecular signatures of ageing and injury in the peripheral nervous system

This study compares molecular changes in PNS ageing, dietary restriction, and injury, finding similar proteomic signatures between ageing and injury.

Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria

This study shows that inhibiting PRX-11 in C. elegans reduces peroxisome degradation, improves mitochondrial health, and extends lifespan.

Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways

This study shows that exposure to lysed C. elegans remains extends lifespan via distinct pathways in young and aged worms, independent of ascaroside pheromones or bacterial lysates.

In Silico Network Perturbation Reveals Hierarchical Roles of DNA Repair and Glycosylation Linking Exercise to Human Ageing Clocks

The paper uses in silico network perturbation to link exercise to ageing clocks by integrating multi-omic data and experimental validation.

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality

This study shows that Δ133p53α extends lifespan and improves tissue health in a progeria mouse model, suggesting potential therapeutic applications for both progeria and ageing.

Transcriptome-wide association study and fly experiments uncover the role of CoA synthase in ageing across species.

The paper performs a transcriptome-wide association study on human lifespan and validates findings in Drosophila, identifying COASY as a gene involved in ageing across species.

Why we age: the four process model

The paper proposes a four-process model of ageing that connects DNA damage, metabolic slowdown, and cellular selection to explain age-related diseases and the evolutionary basis of ageing.

Lifespan and fecundity impacts of reduced insulin signalling can be directed by mito-nuclear epistasis in Drosophila

The paper investigates how reduced insulin signalling affects lifespan and fecundity in Drosophila, showing that mito-nuclear epistasis determines whether the effects are beneficial or detrimental.

A Robust Chemical-free Platform for Age-Synchronized Caenorhabditis elegans Populations Maintenance for High-Throughput Screening in Aging Studies

This paper introduces a chemical-free method to maintain age-synchronized C. elegans populations in a 96-well plate for 12 days, enabling high-throughput screening of compounds and RNAi libraries.

ATG-18 drives longevity in an HLH-30-dependent manner

This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.

The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth

The paper shows that Drosophila proventriculus cells compensate for age-related cell loss through endocycling rather than stem cell proliferation.

PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in C. elegans

This paper introduces PRO-FitS, a C. elegans-based phenotypic assay to identify proteostasis enhancers, validated through mTOR inhibition and serotonergic signaling effects on heat shock-induced proteotoxicity.

PersonaAI: An Interactive Agentic-AI Framework for Autonomous Hypothesis Generation and Validation in Aging

PersonaAI generates and validates aging-related hypotheses using literature and single-cell RNA-seq data, identifying novel aging mechanisms.

Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice

The paper analyzes longitudinal body weight data in mice to identify traits linked to lifespan, finding heritable traits associated with energy homeostasis and longevity.

Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line

The paper shows that pre-dauer starvation reduces germline size and Notch signaling in C. elegans, with long-term reproductive effects, and that these changes are reversible upon recovery.

Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage

This study shows that rapamycin improves genome stability in aged human immune cells by reducing DNA damage, enhancing cell survival, and decreasing senescence markers.

Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan

This study shows that knocking down Rbp1, a fly spliceosome component, extends lifespan regardless of when the treatment is initiated.

Integrating AI and causal genetics to prioritize therapeutic targets for aging and age-related diseases

The paper uses AI and causal genetics to identify shared therapeutic targets for aging and 12 age-related diseases across four disease areas.

Microbiome-host interactions drive a trade-off between sleep quality and lifespan in Drosophila

This study shows that microbiome-host interactions in Drosophila create a trade-off between sleep quality and lifespan through specific bacterial metabolites and host responses.

The aging transcriptome: a condition-dependent response to a deteriorating soma

This study shows that gene expression changes in aging Drosophila are similar to those caused by reduced physiological condition, suggesting aging is a plastic response to somatic decline.

Development of an organotypic brain slice culture model using tissues collected from geriatric mice

This study develops an organotypic brain slice culture model from geriatric mice, showing viability and response to stressors, suggesting its potential for aging and neurodegenerative disease research.

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

Maximal human lifespan in light of a mechanistic model of aging

The paper uses a mechanistic model of aging to show that maximal human lifespan is primarily determined by damage production and clearance rates, with lifestyle factors only modestly affecting it.

Dogs and humans share biomarkers of mortality

The paper identifies shared plasma metabolomic biomarkers of mortality in dogs and humans, showing strong correlations between metabolite effects on all-cause mortality in both species.