Genetics, Aging, and Longevity in Model Organisms

Pharmacologic AMPK Activation Extends Lifespan in C. elegans and Improves Aspects of Healthspan in Mice

This study shows that pharmacologic AMPK activation with MK-8722 extends lifespan in C. elegans and improves metabolic health in aged mice.

Proteome-aware organ proxy aging clocks

This paper develops a proteome-aware aging clock for multi-organ assessment using plasma proteomics, showing it correlates with physiological phenotypes and disease aging landscapes.

Suppression rather than activation of the integrated-stress-response (GCN2-ATF4) pathway extends lifespan in the fly

This study shows that suppressing the GCN2-ATF4 pathway extends lifespan in flies, while its activation reduces lifespan, revealing a dual role in aging.

Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress

The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.

Phosphatidylinositol Transfer Protein-1 Integrates Insulin/IGF-1 and TOR Signaling to Negatively Regulate Lifespan and Healthspan in Caenorhabditis elegans

This study identifies pitp-1 as a regulator of healthy aging in C. elegans that integrates insulin/IGF-1 and TOR signaling to influence lifespan and healthspan.

MOSAIC: a longitudinal phenotypic clock to dissect organismal aging trajectories in C. elegans

The paper develops MOSAIC, a non-invasive phenotypic clock for C. elegans that estimates biological age longitudinally and reveals distinct aging trajectories from lifespan interventions.

Resilience to cardiac aging in Greenland shark Somniosus microcephalus

This study examines cardiac aging in Greenland sharks, finding fibrosis, lipofuscin, and oxidative damage but no physiological decline, suggesting resilience to aging.

Pathological mitochondrial dysfunction mimics an aging pathway in budding yeast

The paper shows that mitochondrial dysfunction in budding yeast mimics aging by causing a state with low membrane potential and heme loss, affecting both young and old cells.

Dietary restriction promotes neuronal resilience via ADIOL

This paper identifies ADIOL as a mediator of dietary restriction's healthspan benefits, showing it improves aging indicators without extending lifespan.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

Translational toolkit for reproducible, cross-study profiling of human ageing hallmarks in human blood and tissue

The paper develops a toolkit to measure multiple ageing hallmarks in human blood and tissue samples, identifying age-related changes in immune cells, senescence, and mitochondrial function.

Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.

The paper identifies a decline in phosphatidylcholine synthesis as a driver of mitochondrial aging that can be reversed by dietary interventions in both worms and human cells.

Caffeine extends lifespan by enhancing lysosomal lipolysis in Caenorhabditis elegans

This study shows caffeine extends lifespan in C. elegans by enhancing lysosomal lipolysis through a dietary restriction-like transcriptional program.

Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging

This study shows that reducing insulin/IGF-1 signaling in early adulthood extends healthspan and lifespan, but in later life, it accelerates aging and reduces lifespan.

Longevity Bench: Are SotA LLMs ready for aging research?

The paper introduces LongevityBench, a benchmark to evaluate LLMs' ability to understand aging biology and predict age-related outcomes from biodata.

Intermediate induction of germline apoptosis maintains fertility and progeny fitness during temperature stress

The paper investigates how C. elegans maintains fertility and progeny fitness during moderate temperature stress by examining the role of germline apoptosis.

A leukemia-derived ENL/AF9 chemical probe enhances neuronal stress resilience and ameliorates ALS phenotypes

This study shows that the ENL/AF9 inhibitor SR-0813 improves neuronal stress resilience and alleviates ALS-like phenotypes in Drosophila and human neurons.

Small-molecule IGF1R inhibitors extend healthspan in a mouse model

This study tests small-molecule IGF1R inhibitors in mice to extend healthspan, finding improved physiological parameters and extended healthspan in one compound, but with toxicity and side effects.

An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging

The paper introduces TimeFlies, an snRNA-seq aging clock for Drosophila heads, identifies key lncRNAs as biomarkers, and shows sex-specific aging pathways.

Acute Smurf mortality and age-dependence in a two-phase ageing model: Statistical inference from drosophila and mice experimental data

The paper develops a two-phase ageing model using Drosophila and mouse data, showing a sharp transition to frailty with high early mortality and age-dependent mortality rates.

Long-lived yeast-derived lipids promote longevity via regional and systemic metabolic remodeling

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

The paper identifies complement deactivation as an immunometabolic checkpoint reduced by calorie restriction, which lowers inflammaging in humans and mice.

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

This study creates a multi-omic atlas of brain aging in African turquoise killifish, identifying glucocorticoid signaling activation as a key feature of aging and showing its inhibition can reverse aging phenotypes.

A Fluorescent Dauer Marker in Caenorhabditis inopinata Enables Comparative Analysis of Dauer-Inducing Mechanisms

The paper develops a fluorescent dauer marker in C. inopinata to compare dauer-inducing mechanisms with C. elegans, finding mechanistic differences in response to temperature and insulin/IGF-1 pathway genes.

Stress-Induced PTBP1 Reprograms Neuronal Function and Activates Cellular Senescence

The paper identifies PTBP1 as a stress-inducible factor that reprograms neuronal function and activates cellular senescence through transcriptional changes.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice

This study shows that ovariectomy in female mice enhances their metabolic response to a low protein diet, aligning it with males, while castration has little effect on males.

A cluster of three snoRNAs including jouvence required in the gut determines lifespan and confers neuroprotection through metabolic parameters

The paper identifies three snoRNAs in Drosophila that regulate lifespan and neuroprotection through metabolic pathways in the gut and brain.

The End of Aging Clocks: Training Foundation Models to Reason in Aging and Longevity

The paper introduces Longevity-LLM, a foundation model fine-tuned on aging-related data, achieving high performance in age prediction and proteomic profile generation across multiple modalities.