Bone Metabolism and Diseases

Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis

This paper shows cathepsin K inhibitors enhance osteoclast-osteoblast communication and promote osteogenesis, suggesting their unique role in balancing bone resorption and formation.

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts

The paper uses high-content imaging to identify anti-resorptive GPCRs in human osteoclasts, finding four receptors that reduce osteoclast activity.

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

This paper improves a murine bone marrow injury model to study intramembranous ossification and assess postnatal osteogenesis regulators.

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.

Homeostatic balance of Gut-resident Tregs (GTregs) plays a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions

This study shows that gut-resident Tregs (GTregs) regulate bone health in post-menopausal osteoporosis by modulating osteoblast and osteoclast activity, with probiotics and SCFAs enhancing their effectiveness.

MiR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells

This study shows miR-125b differentially affects mineralization in hMSCs under dexamethasone or calcium treatment, with opposite effects on osteogenic markers and target gene modulation.

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

This study identifies miR-335-3p as a key regulator of osteoclast activity under psychological stress, showing its downregulation leads to FOS accumulation and osteoporosis.

Osteogenic CpG oligodeoxynucleotide, iSN40, inhibits osteoclastogenesis in a TLR9-dependent manner

This study shows that iSN40, a CpG-ODN, inhibits osteoclast formation via TLR9-dependent mechanisms and may be a therapeutic for osteoporosis.

Rejuvenating aged osteoprogenitors for bone repair

This study identifies age-related impairments in bone healing and presents a rejuvenation strategy combining Wnt-mediated osteoprogenitor expansion and intermittent fasting to restore youthful bone repair in aged mice.

WISH-BONE: Whole-mount In Situ Histology, to label osteocyte mRNA and protein in 3D adult mouse bones

WISH-BONE labels osteocyte mRNA and protein in 3D adult mouse bones, enabling spatially preserved biomarker expression analysis.

Stage-Specific Modulation of Multinucleation, Fusion and Resorption by the Long Non-coding RNA DLEU1 and miR-16 in Human Primary Osteoclasts

This study shows that DLEU1 and miR-16 regulate osteoclast fusion and resorption through distinct mechanisms, suggesting potential therapeutic targets for bone diseases.

Legumain is a paracrine regulator of osteoblast differentiation and mediates the inhibitory effect of TGF-β1 on osteoblast maturation

This study identifies legumain as a paracrine factor mediating TGF-β1's inhibitory effect on osteoblast maturation through increased secretion and internalization.

Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

This study shows that inhibiting Cx3cr1+iOCs enhances CGRP+TrkA+ sensory signaling and accelerates callus remodeling in osteoporotic fractures.

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

Phase diagrams of bone remodeling using a 3D stochastic cellular automaton

This paper introduces a 3D stochastic cellular automaton model to simulate bone remodeling dynamics and derives a phase diagram showing how parameter changes affect the process.

Loss of ninein interferes with osteoclast formation and causes premature ossification

This study shows that ninein deficiency impairs osteoclast formation and bone resorption, leading to premature ossification and altered skeletal development.

Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow

This study shows that targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by modulating signaling pathways and stem cell fate.

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein

This study identifies an oxidized form of La protein at the osteoclast surface, driven by ROS signaling, which promotes multinucleation and bone resorption.

Defining the most potent osteoinductive culture conditions for MC3T3-E1 cells reveals no implication of oxidative stress or energy metabolism

The study identifies optimal culture conditions for MC3T3-E1 cells to achieve mineralization, finding no role for oxidative stress or energy metabolism.

A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone

This study creates a harmonized atlas of murine bone-associated cells using single-cell RNA sequencing to clarify cell type designations and identify osteoblast progenitors.

The calcium channel Orai1 is required for osteoblast development: studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

This study shows that Orai1 is essential for osteoblast development by using chimeric mice with conditional deletion of Orai1 in osteoprogenitor cells, revealing impaired bone formation and mineralization.

MMP14 cleaves PTH1R in the chondrocyte derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

The paper identifies MMP14 as a regulator of PTH signaling in osteoblast lineage cells, showing that MMP14 cleavage of PTH1R reduces signaling intensity, promoting bone anabolism.

MicroRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling

This study identifies miR-27a as essential for bone remodeling by regulating p62-mediated osteoclast signaling, leading to severe osteoporosis in mice.

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

The paper shows that osteoclast-mediated resorption of calcified tissue is essential for successful skeletal integration during axolotl limb regeneration.

Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

This study investigates the role of Ksr2 in bone health, finding it negatively regulates femoral bone mass and influences adipocyte differentiation over osteoblasts in the bone marrow.

Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway

The paper shows that inhibiting ERK in mature osteoblasts enhances bone formation through mTOR pathway activation, revealing a dual role of ERK in osteoblast differentiation.

Mathematical modeling of the effects of Wnt-10b on bone metabolism

The paper models the effects of Wnt-10b on bone metabolism using differential equations and validated parameters from mouse data, predicting increased pre-osteoblasts and osteoblasts and decreased osteoclasts.

Osteoblast cell death triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish

The paper shows that osteoblast death in zebrafish triggers macrophage recruitment via reactive oxygen species, which is modulated by glucocorticoids and essential for osteoblast repopulation of lesions.

SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation.

The paper identifies SLC38A2 as essential for proline supply during osteoblast differentiation and bone formation, showing its role in proline-rich protein synthesis.