Lipid metabolism and biosynthesis

2-Hydroxyglutarate Redirects Fatty Acid Partitioning to Mitigate Lipotoxic Stress and Preserve Metabolic Fuel

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

Monitoring Fatty Acid Trafficking during Drosophila oogenesis Reveals a Role for the Triglyceride Synthase DGAT1 in Protecting Mitochondrial Integrity

The paper investigates fatty acid trafficking during Drosophila oogenesis and shows that lipid droplets buffer mitochondrial lipotoxicity by storing and mobilizing fatty acids for energy production.

On the stabilization of plant lipid droplets: Dynamic interplay between oleosins and phospholipids

This study investigates the dynamic interaction between oleosins and phospholipids in stabilizing plant lipid droplets using microfluidic systems, revealing that oleosins primarily stabilize while phospholipids destabilize the interface.

Acid phospholipase A1 promotes lysosomal membrane catabolism

This study identifies acid phospholipase A1's role in lysosomal glycerophospholipid catabolism and shows its interaction with bis(monoacylglycero)phosphate and inhibition by cationic amphiphilic drugs.

Torsins Organize CLCC1 Assembly to Safeguard ER Bilayer and Lipid Homeostasis

The paper identifies CLCC1 as a client of Torsin ATPases, showing they organize CLCC1 to maintain ER bilayer and lipid homeostasis, with implications for MASH development.

ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila

This study shows that ATGL-mediated lipid droplet lipolysis is essential for collective migration in Drosophila border cells by regulating energy production and mitochondrial function.

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism

This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.

Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility

This study shows that Seipin regulates tripartite ER-mitochondria-lipid droplet contact sites, which are critical for adipocyte lipid storage and metabolic flexibility.

Dithionite quenching of NBD-labeled lipids reveals artificial lipid droplet purity and neutral lipid surface accessibility

Lipid droplet shape and tendency towards budding: insight from theory and molecular simulations

This study uses molecular dynamics simulations and theoretical models to analyze the shape and budding propensity of lipid droplets, finding that their shape resembles a spherical cap and is influenced by membrane properties.

Hepatitis C Virus Remodels Lipid Droplets to Promote Mitochondrial Fatty Acid Accumulation and Metabolic Activation

This paper investigates how HCV remodels lipid droplets during infection, leading to mitochondrial fatty acid accumulation and metabolic activation, with implications for antiviral strategies.

A membrane homeostatic response to lipid overload coordinates fatty acid metabolism

The paper identifies adaptive pathways in hepatocytes that restore homeostasis during lipid overload by coordinating fatty acid oxidation and suppression of unsaturated fatty acid synthesis.

A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans

This study characterizes the effects of reduced phosphatidylcholine synthesis in C. elegans using pcyt-1 mutant alleles, revealing compensatory lipid remodeling and specific developmental vulnerabilities.

Dietary Sodium Deprivation Remodels the Serum Lipidome and Reveals Systemic Metabolic Adaptation in Rats

This study shows that dietary sodium deprivation alters the serum lipidome in rats, revealing metabolic adaptations related to lipid storage, membrane turnover, and mitochondrial function.

Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity

This study identifies activity-dependent lipid droplet formation and lipophagy as critical regulators of synaptic integrity and neuronal function using a novel genetic reporter in cultured neurons and mouse motor cortex.

Regulated conformational transitions in seipin define a functional ER–lipid droplet interface

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

In vivo analyses reveal rapid and permissive lipid transport between the ER and mitochondria

The paper quantifies ER-to-mitochondria lipid transport in yeast, showing rapid exchange and limited substrate selectivity.

Compounds toxic to stationary-phase yeast reveal a role for lipid metabolism in quiescent cell survival

Lipid droplet isolation as a novel platform for spectroscopic investigation of cargo modifications

The paper uses Raman spectroscopy to analyze lipid droplet composition in Schwann and MPNST cells under CBD, radiation, and combined treatments, revealing treatment-specific metabolic changes.

A metabolic labelling-based lipid imaging technology establishes VPS13A as a phosphatidylethanolamine lipid transfer protein

The TCA cycle and pentose phosphate pathway are linked to lipid droplet expansion in nitrogen-starved Lipomyces starkeyi cells

This study shows that in nitrogen-starved Lipomyces starkeyi cells, lipid droplet expansion is linked to the TCA cycle and pentose phosphate pathway, with citric acid and NADPH facilitating fatty acid synthesis and energy storage.

FabF-FadM Cooperate to Recycle Fatty Acids and Rescue ΔplsX Lethality in Staphylococcus aureus

This paper identifies that mutations in fabF or fadM allow Staphylococcus aureus to bypass PlsX dependency by releasing fatty acids, leading to growth rescue but increased beta-lactam sensitivity.

Organelle bridges and nanodomain partitioning govern targeting of membrane-embedded proteins to lipid droplets

The paper shows that LD-targeted proteins are confined by nanodomains and transported via ER-LD bridges, revealing mechanisms for their selective accumulation on lipid droplets.

Inducible lipid storage and steatosis in the human choroid plexus associated with age and adiposity

This study identifies age and adiposity-related lipid droplet accumulation in human choroid plexus epithelial cells, with associations with BMI, sex, and Alzheimer's Disease.

Dehydration promotes intracellular lipid synthesis and accumulation

This study shows dehydration increases intracellular lipid synthesis and accumulation by promoting glutamine oxidation and mitochondrial metabolic remodeling.

SAD-dependent thylakoid lipid desaturation and FDX5-associated electron transfer during copper deficiency in Chlamydomonas reinhardtii

This study shows that copper deficiency in Chlamydomonas reinhardtii increases SAD expression, leading to changes in fatty acid composition and growth, with FDX5 playing a role in electron transfer for lipid desaturation.

A lipid compendium of a metabolically compromised bacterium provides insights into lipid acquisition, biosynthesis, and metabolism

This study identifies a complex lipid profile in Borrelia burgdorferi, revealing its reliance on environmental lipids and its ability to synthesize eukaryotic-like lipids.

Structural basis of substrate recognition and membrane association by the bacterial lysyl-phosphatidylglycerol hydrolase AcvB

The paper determines the crystal structures of AcvB and its catalytic domain, revealing how they recognize and hydrolyze Lys-PG and interact with LpiA for lipid remodeling.

β-Ketoacyl Synthase II Homologs from a Ladderane-Producing Organism Form a Ketosynthase/Chain Length Factor-like functional heterodimer

This paper characterizes two FabF homologs from anammox bacteria that form a functional heterodimer involved in ladderane biosynthesis, revealing their unique mechanism and substrate specificity.

A nucleus-vacuole junction in fission yeast enriches the HMG-CoA reductase Hmg1 and INSIG protein Ins1

The paper identifies a nucleus-vacuole junction in fission yeast that accumulates sterol synthesis factors, showing functional conservation despite the absence of Nvj1.