IL-33, ST2, and ILC Pathways

Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure

This study shows that IL-18 signaling suppresses IL-17A production from ILC2s and eosinophilia in mice exposed to fungal allergens.

Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT+ ILC2 state linked to immune disease susceptibility

This study identifies KIT+ ILC2s as an epigenomically plastic state linked to immune disease susceptibility and shows that STAT5 activation by cytokines induces this phenotype.

CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid Cells

A CRISPRi screen identifies SON and MAP4K1 as regulators of IL-22 and IL-17 expression in innate lymphoid cells, revealing new therapeutic targets for immune-mediated diseases.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation

This paper develops a Wnt-IL-13 fusion protein that activates tuft cells to enhance intestinal regeneration in human organoids.

RANK-DEPENDENT CONTROL OF TUFT AND BEST4 CELL DEVELOPMENT IN THE INTESTINE

This study identifies RANK's role in shaping intestinal epithelial cell specialization in zebrafish, showing its impact on tuft and BEST4 cell development and immune responses.

The long non-coding RNA Dreg1 is required for optimal ILC2 development

This study identifies Dreg1 as a non-coding RNA essential for ILC2 development, regulated by Tcf1 and influencing Gata3 expression levels.

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells

This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.

ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION

This study shows that androgens protect ILC2s from functional suppression during influenza virus infection by regulating IFNGR-STAT1 signaling.

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism

This study shows trained ILC2s prevent IL-17-driven lung injury during helminth re-infection via a serotonin-dependent mechanism, distinct from TH2 cells.

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

The Changing Immune Landscape of Innate-like T Cells and Innate Cells Throughout Life

This study uses spectral flow cytometry to analyze age-related changes in innate and innate-like T cells, identifying age-associated phenotypic shifts in immune cell subsets.

Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit

The paper shows that telocytes relay signals from enteroendocrine cells to ILC2s, amplifying the tuft cell circuit in response to feeding.

IL-25-induced memory ILC2s mediate long-term small intestinal adaptation

This study shows that IL-25 induces memory ILC2s in the small intestine that provide long-term protection against barrier pathogens.

Dissecting the Heterogeneity and Tumor-Associated Dynamics of Human Liver Group I ILC via scRNA Sequencing Data

This study uses scRNA-seq to analyze human liver ILC1s and their dynamics in the tumor microenvironment, identifying key gene expression patterns and potential roles in hepatocellular carcinoma progression.

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

Peritoneal cavity-derived GATA6+ macrophages inhibit fibrosis through IL33 in endometrium

The paper identifies GATA6+ macrophages from the peritoneal cavity that inhibit endometrial fibrosis via IL33, revealing their role in endometrial repair.

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

This study shows that colonic ILC2s are activated during Citrobacter rodentium infection, secreting type 2 cytokines, and that IL-18 drives their activation.

HSP70 chaperones IL-33 in chronic airway disease

This study identifies HSP70 as a chaperone that facilitates the secretion and activity of the IL-33{Delta}34 isoform in chronic airway diseases.

Immunometabolic analysis of primary murine Group 2 Innate Lymphoid Cells: a robust step-by-step approach

This paper provides a step-by-step framework to analyze immunometabolic states of primary murine ILC2s and link them to phenotypes and functionality.

IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity

The paper shows IL-33 prevents recurrent C. difficile infection by restoring anti-TcdB antibody production through ILC2-TFH cell interactions.

Dynamic roles of ILC3 in endometrial repair and regeneration

This study identifies two subsets of ILC3 in the human endometrium, showing their distinct roles in repair and regeneration during different physiological states.

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

This study shows that group 2 innate lymphoid cells (ILC2s) and their cytokine IL-13 promote inhibitory synapse development and adult social behavior.

PIP-Seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure

The paper introduces PIP-Seq to study lung ILC activation after exposure to environmental toxins, identifying novel ILC subsets and activation pathways.

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

RAG suppresses group 2 innate lymphoid cells

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.