IL-33, ST2, and ILC Pathways

Evasion of Hepatic ILC1 Immunosurveillance Drives Breast Cancer Liver Metastasis

This study identifies liver-resident ILC1s as a critical barrier against breast cancer liver metastasis, showing that DR5 expression and host metabolism influence this immunosurveillance.

Comparative transcriptomic analysis of intestinal Tuft cells reveals species selectivity of DCLK1 expression

This study compares transcriptomic data across species to assess DCLK1 expression in intestinal tuft cells, highlighting species-specific differences in its expression.

A unique intestinal epithelial cell that expresses canonical lymphoid genes

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

The helminth-derived effector protein HpBARI trimerises to selectively target membrane bound ST2 receptor

This paper describes the structure of HpBARI2, a helminth-derived protein that trimerises to selectively inhibit membrane-bound ST2 receptor signaling by blocking IL-33 binding and preventing co-receptor recruitment.

RasGRP1 promotes efficient intestinal tuft cell differentiation

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

Single-Cell Profiling Reveals Innate Lymphoid Cells and OX40 Activation in Breast Cancer-Related Lymphedema

This study identifies OX40-dependent innate lymphoid cell signaling as a novel regulatory program in breast cancer-related lymphedema.

Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure

This study shows that IL-18 signaling suppresses IL-17A production from ILC2s and eosinophilia in mice exposed to fungal allergens.

The transcription factor Bhlhe40 promotes inflammatory functions of ILC2s through inducing GM-CSF while inhibiting IL-10 expression

This study shows Bhlhe40 promotes GM-CSF and inhibits IL-10 in ILC2s, enhancing eosinophil recruitment during type 2 immune responses.

Human ILC methylomes uncover stable lineage codes and disease-linked ILC2 regulators in allergy

This study maps DNA methylation patterns in human ILC subsets, identifies disease-linked regulators in ILC2, and shows their role in allergic inflammation.

IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

Elastin-derived peptides suppress CCL20 expression and block ILC2 recruitment during lung inflammation

Elastin-derived peptides reduce CCL20 expression and inhibit ILC2 recruitment during lung inflammation, linking ECM degradation to type 2 immunity regulation.

Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT+ ILC2 state linked to immune disease susceptibility

This study identifies KIT+ ILC2s as an epigenomically plastic state linked to immune disease susceptibility and shows that STAT5 activation by cytokines induces this phenotype.

CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid Cells

A CRISPRi screen identifies SON and MAP4K1 as regulators of IL-22 and IL-17 expression in innate lymphoid cells, revealing new therapeutic targets for immune-mediated diseases.

Mite-induced migratory skin-like CD103+ ILC2s establish lung residency and impact immunity

The paper shows that mite-induced migratory CD103+ skin ILC2s enter the lung, become resident, and alter lung immunity by changing immune response trajectories.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation

This paper develops a Wnt-IL-13 fusion protein that activates tuft cells to enhance intestinal regeneration in human organoids.

RANK-DEPENDENT CONTROL OF TUFT AND BEST4 CELL DEVELOPMENT IN THE INTESTINE

This study identifies RANK's role in shaping intestinal epithelial cell specialization in zebrafish, showing its impact on tuft and BEST4 cell development and immune responses.

The long non-coding RNA Dreg1 is required for optimal ILC2 development

This study identifies Dreg1 as a non-coding RNA essential for ILC2 development, regulated by Tcf1 and influencing Gata3 expression levels.

Influenza-induced tuft cell expansion alters ILC-mediated inflammation

This study shows that influenza-induced tuft cell expansion interacts with ILC2s to regulate inflammation, with tuft cell deficiency altering ILC subsets and inflammatory responses.

Obesity selectively disrupts long-lasting type 2 immune cell depots in white adipose tissue

This study shows obesity disrupts type 2 immune cell depots in white adipose tissue, impairing immunological memory without affecting acute immune responses.

Natural microbial exposure imposes layered constraints on epithelial and type 2 immunity

The study shows that natural microbial exposure reduces tuft cell responsiveness in mice, affecting type 2 immunity and helminth resistance compared to sterile conditions.

Circulating inflammatory ILC2s as a biomarker of gastric cancer progression

This study identifies circulating inflammatory ILC2s as a biomarker for gastric cancer progression, showing their association with disease severity and potential for early detection.

ILC3s are Required for Enterocyte Homeostasis to Food Intake

This study shows that ILC3s prevent post-prandial inflammation by regulating enterocyte metabolism during food intake.

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells

This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.

ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION

This study shows that androgens protect ILC2s from functional suppression during influenza virus infection by regulating IFNGR-STAT1 signaling.

Substance matters: IL5 and IL33 activation of eosinophils on periostin and fibrinogen induce cytoskeletal reorganization and cell death

This study compares how IL5 and IL33 activate eosinophils on fibrinogen and periostin, showing distinct morphological and viability changes.

Targeting Myc activates a tissue-specific tumour resolution programme

This study shows that targeting Myc in lung adenocarcinoma activates an immune programme that drives tumour regression through IL-33-mediated eosinophil recruitment.

ST2 Signaling Regulates Innate Immune Responses in Kidney Injury

This study investigates the role of ST2 signaling in innate immune responses during kidney injury, finding that ST2 deletion reduces acute injury but worsens chronic injury.

Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism

This study shows trained ILC2s prevent IL-17-driven lung injury during helminth re-infection via a serotonin-dependent mechanism, distinct from TH2 cells.

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.