IL-33, ST2, and ILC Pathways

Evasion of Hepatic ILC1 Immunosurveillance Drives Breast Cancer Liver Metastasis

This study identifies liver-resident ILC1s as a critical barrier against breast cancer liver metastasis, showing that DR5 expression and host metabolism influence this immunosurveillance.

Comparative transcriptomic analysis of intestinal Tuft cells reveals species selectivity of DCLK1 expression

This study compares transcriptomic data across species to assess DCLK1 expression in intestinal tuft cells, highlighting species-specific differences in its expression.

A unique intestinal epithelial cell that expresses canonical lymphoid genes

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

The helminth-derived effector protein HpBARI trimerises to selectively target membrane bound ST2 receptor

This paper describes the structure of HpBARI2, a helminth-derived protein that trimerises to selectively inhibit membrane-bound ST2 receptor signaling by blocking IL-33 binding and preventing co-receptor recruitment.

RasGRP1 promotes efficient intestinal tuft cell differentiation

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

Single-Cell Profiling Reveals Innate Lymphoid Cells and OX40 Activation in Breast Cancer-Related Lymphedema

This study identifies OX40-dependent innate lymphoid cell signaling as a novel regulatory program in breast cancer-related lymphedema.

The transcription factor Bhlhe40 promotes inflammatory functions of ILC2s through inducing GM-CSF while inhibiting IL-10 expression

This study shows Bhlhe40 promotes GM-CSF and inhibits IL-10 in ILC2s, enhancing eosinophil recruitment during type 2 immune responses.

Human ILC methylomes uncover stable lineage codes and disease-linked ILC2 regulators in allergy

This study maps DNA methylation patterns in human ILC subsets, identifies disease-linked regulators in ILC2, and shows their role in allergic inflammation.

IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

Elastin-derived peptides suppress CCL20 expression and block ILC2 recruitment during lung inflammation

Elastin-derived peptides reduce CCL20 expression and inhibit ILC2 recruitment during lung inflammation, linking ECM degradation to type 2 immunity regulation.

Mite-induced migratory skin-like CD103+ ILC2s establish lung residency and impact immunity

The paper shows that mite-induced migratory CD103+ skin ILC2s enter the lung, become resident, and alter lung immunity by changing immune response trajectories.

Influenza-induced tuft cell expansion alters ILC-mediated inflammation

This study shows that influenza-induced tuft cell expansion interacts with ILC2s to regulate inflammation, with tuft cell deficiency altering ILC subsets and inflammatory responses.

Obesity selectively disrupts long-lasting type 2 immune cell depots in white adipose tissue

This study shows obesity disrupts type 2 immune cell depots in white adipose tissue, impairing immunological memory without affecting acute immune responses.

Natural microbial exposure imposes layered constraints on epithelial and type 2 immunity

The study shows that natural microbial exposure reduces tuft cell responsiveness in mice, affecting type 2 immunity and helminth resistance compared to sterile conditions.

Circulating inflammatory ILC2s as a biomarker of gastric cancer progression

This study identifies circulating inflammatory ILC2s as a biomarker for gastric cancer progression, showing their association with disease severity and potential for early detection.

ILC3s are Required for Enterocyte Homeostasis to Food Intake

This study shows that ILC3s prevent post-prandial inflammation by regulating enterocyte metabolism during food intake.

Substance matters: IL5 and IL33 activation of eosinophils on periostin and fibrinogen induce cytoskeletal reorganization and cell death

This study compares how IL5 and IL33 activate eosinophils on fibrinogen and periostin, showing distinct morphological and viability changes.

Targeting Myc activates a tissue-specific tumour resolution programme

This study shows that targeting Myc in lung adenocarcinoma activates an immune programme that drives tumour regression through IL-33-mediated eosinophil recruitment.

ST2 Signaling Regulates Innate Immune Responses in Kidney Injury

This study investigates the role of ST2 signaling in innate immune responses during kidney injury, finding that ST2 deletion reduces acute injury but worsens chronic injury.

ILC2s govern imprinting of alveolar macrophage-mediated immunity upon secondary helminth infection in the lung

This study shows ILC2s regulate alveolar macrophage dynamics and function during secondary helminth infection by modulating their metabolism and parasite-killing capacity.

Il33 expressing cDC2s promote expansion of ILC2s and eosinophilia in fungal airway inflammation in male mice

The paper shows that Il33-expressing cDC2s drive ILC2 expansion and eosinophilia in male mice during fungal airway inflammation, independent of ST2 and dependent on IL-4/13.

Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses

This study shows that exposure to ETEC or its toxin LT reduces lung allergic inflammation by inhibiting IL-33 responses in ILC2 cells through a gut-derived negative feedback loop.

Transcriptomic and proteomic analysis show minimal role formast cell ST2 in primary Heligmosomoides polygyrus bakeriinfection

This paper investigates the role of mast cell ST2 in Heligmosomoides polygyrus bakeri infection using transcriptomic and proteomic analysis, finding minimal impact on infection outcomes.

Group 2 Innate lymphoid cells promote allograft survival by constraining and inducing anergy in alloreactive CD4+ T cells

This study shows that recipient-derived ILC2s promote allograft survival by inducing anergy in alloreactive CD4+ T cells through antigen presentation and the Caspase-3 pathway.

IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition

This study shows IL-26 from innate lymphoid cells regulates gut epithelial homeostasis by shaping microbiota composition in zebrafish larvae.

Prevalent cross-cell type QTL trans-regulatory genetic effects impacting innate lymphoid cells in the small intestine

The paper identifies genetic variants affecting innate lymphoid cells in the gut using single-cell RNA-seq and validates their regulatory roles across cell types.

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive lymphoid cells

The paper identifies two enhancers regulating IL-22 expression in type 3 lymphoid cells, showing distinct roles in different subsets and functions in disease models.

The IL-33/ST2 signaling axis drives pathogenesis in acute SARS-CoV-2 infection

This study shows that blocking the IL-33/ST2 signaling axis improves survival in a mouse model of SARS-CoV-2 infection without affecting viral load.

Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-gamma in innate lymphoid cells during homeostasis.

The paper shows adaptive immunity limits IFN-gamma-driven changes in innate and epithelial cells during homeostasis by suppressing ILC-type 1 polarization.