Epilepsy research and treatment

A Brain Circuit for Status Epilepticus

This study identifies a unified brain circuit associated with status epilepticus using multimodal lesion mapping and gene expression analysis, showing high accuracy in distinguishing SE from other lesion etiologies.

Light and temperature sensitive seizures are regulated by spatially distinct cortex glial populations in the central nervous system

The paper shows that light- and temperature-sensitive seizures are regulated by distinct cortex glial populations in different brain regions of Drosophila.

Multiscale alterations and cortex-wide organizational trends in focal cortical dysplasia

This paper quantifies multiscale MRI changes in focal cortical dysplasia lesions and links them to macroscale brain organization patterns.

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

The paper identifies early changes in hippocampal network activity that predict subsequent epilepsy in rats following perforant pathway stimulation.

Computational demands shape seizure susceptibility in recurrent neural networks

This study shows that neural network computations, not just anatomy, influence seizure susceptibility in brain regions.

Microglia and its P2RY12 Receptors Regulate Seizure Severity

This study shows that microglia reduce seizure severity through P2RY12 signaling, as demonstrated in genetic models and seizure paradigms.

Hippocampal microcircuits constrain the generation of epileptiform activity

This study shows that microcircuit-specific inhibition in the hippocampus can drive epileptiform activity, highlighting the role of cellular-level organization in epilepsy.

A Zebrafish Platform to Model Human SCN2A and SCN8A Epilepsy and Evaluate Anti-Seizure Medications

The paper establishes a zebrafish model to evaluate seizure activity caused by SCN2A and SCN8A variants and tests the efficacy of anti-seizure medications.

Cortistatin neurons in the prelimbic cortex regulate seizure susceptibility in female mice via BDNF-TrkB signaling

This study shows that loss of cortistatin (CST) neurons in the prelimbic cortex increases seizure susceptibility and anxiety-like behaviors in female mice, suggesting shared mechanisms between epilepsy and stress-related disorders.

Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

4 Phenylbutyrate Plus Gene augmentation: A dual therapy To Rescue of SLC6A1 Variant Associated Developmental And Epileptic Encephalopathy

This paper demonstrates that the SLC6A1 A305V variant causes GAT-1 destabilization and ER retention, which can be rescued by pharmacologic chaperones like PBA and gene augmentation.

Focal astrocyte Kir4.1 loss drives seizures, spreading depolarizations and postictal impairments

This study shows that focal loss of astrocytic Kir4.1 in the adult hippocampus causes seizures, spreading depolarizations, and postictal impairments.

Pathology in resected areas of FDG PET hypometabolism in pediatric epilepsy patients with focal cortical dysplasia type II

The paper examines histopathology in FDG-PET hypometabolic regions of pediatric epilepsy patients with FCD type II, finding fFCD concentrated at the lesion epicenter and DNO present in both epicenter and hypometabolic borders.

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study

This study examines sex differences in structural brain alterations in common epilepsies using neuroimaging data from a large international cohort, finding some regional differences but no significant sex-by-diagnosis interactions.

Kainic Acid Pig Model of Hippocampal Epilepsy

This paper develops a porcine model of mesial temporal lobe epilepsy using kainic acid and an implantable device to study seizures and electrophysiological features.

Slow Oscillations Gate Interictal Spikes Across the Human Thalamocortical-Epileptogenic Network

The paper investigates how slow oscillations gate interictal spikes across the thalamocortical-epileptogenic network in human epilepsy, finding region-specific coupling and predictive pre-onset phase-amplitude coupling.

Seize the Data: A User-Friendly GUI for High-Resolution Analysis of Seizure Dynamics in HD-MEA Recordings

The paper introduces YSA, an open-source GUI for analyzing HD-MEA recordings, enabling efficient visualization and exploration of seizure dynamics in neural data.

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure Sequelae

This study shows that inhibiting MAGL in astrocytes reduces seizures and neuroinflammation by activating CB1-PPAR-γ signaling, preserving synaptic function and preventing cognitive decline in epilepsy.

Circadian Modulation of Excitation-Inhibition Balance Drives Ictal Transitions in a Mechanistic Model of Epileptic Networks

This study develops a computational model showing how circadian rhythms modulate excitation-inhibition balance to drive seizure-like dynamics in neuronal networks.

Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model

This study examines how chronic stress affects synaptic neurotransmission in a Dravet syndrome mouse model, revealing altered excitatory and inhibitory synaptic activity in BNST CRF neurons.

Chronic In Vivo Imaging of a Focal Cortical Dysplasia Mouse Model Reveals Progressive Neuronal Loss with No Senolytic or Antiseizure Efficacy Following Dasatinib-Quercetin Treatment

The paper tracks neuronal loss in an FCD mouse model and finds no reduction in seizures or neuron elimination with DQ treatment, suggesting strain-specific effects.

Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of SCN2A-Related Disorders

This study examines the impact of a SCN2A pathogenic variant in human neurons using electrophysiology and machine learning, showing that sodium channel blockers can restore normal function.

Individualized and stereotypical seizure semiology in a porcine model of post-traumatic epilepsy.

This study examines seizure patterns in a porcine model of post-traumatic epilepsy, finding that seizures start focally and evolve to generalized convulsions with stereotypical behaviors.

Assessing the degree of cortical dislamination through electrical pattern analysis

This study quantifies cortical dislamination using electrical pattern analysis in an animal model and links it to neural dynamics and excitation-inhibition balance.

Thalamic Interictal Epileptic and Non-Epileptic Events during NREM Sleep in Patients with Focal Epilepsy: a Stereo-EEG Study

This study analyzes thalamic interictal events during NREM sleep in patients with focal epilepsy, finding associations between specific thalamic activity patterns and surgical outcomes.

Reduction of Nav1.1 in the dorsal striatum preferentially increases hyperthermia-induced generalized seizures compared with the neocortex and nucleus accumbens

This study shows that reducing Nav1.1 in the dorsal striatum increases hyperthermia-induced seizures more than in the neocortex or nucleus accumbens.

Wnt activation prevents epileptogenic hippocampal remodeling in animal models of unilateral and bilateral temporal lobe epilepsy

This study shows that Wnt activation reduces epileptogenic hippocampal remodeling in TLE models by restoring Wnt signaling in immature dentate granule cells.

A photoswitchable cannabinoid for precision treatment of refractory seizures in a mouse epilepsy model

The paper demonstrates the use of a photoswitchable cannabinoid, azo-THC-3, to suppress seizures in a mouse model by local photoactivation in the hippocampus, avoiding systemic side effects.

Altered Physiology and Ensemble Recruitment of Dentate Gyrus Semilunar Granule Cells in a Mouse Model of Epilepsy

This study identifies altered intrinsic excitability and circuit connectivity in semilunar granule cells in a mouse epilepsy model, contributing to spatial navigation deficits.

On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy

This study develops an on-demand seizure induction method in chronically epileptic mice to improve therapeutic screening for epilepsy.