Glaucoma and retinal disorders

MCT2 Overexpression Rescues Metabolic Vulnerability and Protects Retinal Ganglion Cells in Two Models of Glaucoma

This study shows that overexpressing MCT2 in glaucoma models preserves retinal ganglion cells and improves energy homeostasis by enhancing ATP production and mitochondrial function.

Experimental glaucoma retinal proteomics identifies mutually exclusive and overlapping molecular characteristics with human glaucoma

This study compares proteomic changes in a rat glaucoma model with human glaucoma, identifying shared and distinct molecular features related to oxidative stress, mitochondrial dysfunction, and immune pathways.

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

The paper identifies rare protein-altering variants in ANGPTL7 that lower intraocular pressure and reduce glaucoma risk by analyzing genotyping data from UK Biobank and FinnGen.

Oral pyruvate prevents glaucomatous neurodegeneration

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.

POU6F2 Positive Retinal Ganglion Cells a Novel Group of ON-OFF Directionally Selective Subtypes in the Mouse Retina.

The paper identifies POU6F2 as a marker for a novel group of ON-OFF directionally selective retinal ganglion cells that are sensitive to glaucomatous injury.

Genome wide-association study identifies novel loci in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study

The paper identifies a novel POAG-associated SNP in African Americans using a genome-wide association study.

Correlation between Retinal Ganglion Cell Loss and Nerve Crush Force-Impulse Established with an Instrumented Tweezers in Mice

The paper develops an instrumented tweezers system to measure optic nerve crush forces and establishes a correlation between axon loss and force-impulse in mice.

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

Interaction of intraocular pressure and ganglion cell function in open angle glaucoma

The paper tests simultaneous IOP and PERG measurements during LDP and finds IOP changes affect PERG amplitudes in lower eyes.

Congenital glaucoma with anterior segment dysgenesis in individuals with biallelic CPAMD8 variants

The paper identifies biallelic CPAMD8 variants as a cause of congenital glaucoma with anterior segment dysgenesis in four individuals from three families.

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension.

The paper shows that removing senescent cells early in a mouse model of ocular hypertension protects retinal ganglion cells from loss and preserves visual function.

Estimating Rates of Progression and Predicting Future Visual Fields in Glaucoma Using a Deep Variational Autoencoder

This paper develops a deep variational autoencoder to estimate glaucoma progression rates and predict future visual field loss, showing improved performance compared to traditional methods.

Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.

DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice

This study investigates the role of DDIT3 in RGC somal loss and axonal degeneration in DBA/2J mice with chronic ocular hypertension, finding that DDIT3 contributes to somal loss but not axonal degeneration.

Changes in extracellular matrix gene and protein expressions in human trabecular meshwork cells in response to mechanical fluid flow stimulation

This study examines how mechanical fluid flow affects ECM gene and protein expression in HTM cells, finding reduced fibronectin and collagen IV levels.

Early-Stage Ocular Hypertension Alters Retinal Ganglion Cell Synaptic Transmission in the Visual Thalamus

This study shows that early-stage ocular hypertension causes pre- and post-synaptic functional and structural changes at retinogeniculate synapses before significant RGC loss.

Long distance retrograde degeneration of the retino-geniculo-cortical pathway in homonymous hemianopia

This study uses OCT to measure retrograde degeneration in patients with homonymous hemianopia, finding earlier and more severe thinning in anterior lesions compared to posterior ones.

Effect of systemic treatment with N--2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush

This study investigates the protective effects of HIOC and TUDCA on retinal ganglion cell (RGC) death following optic nerve crush in mice, finding significant RGC survival in treated groups.

Modulation of post-traumatic immune response using anti-IL-1 therapy for improved visual outcomes

This study shows that blocking the IL-1 pathway with anakinra reduces retinal inflammation and preserves retinal ganglion cell function and structure after blast-induced TBI in mice.

Linking Neural and Clinical Measures of Glaucoma with Diffusion Magnetic Resonance Imaging (dMRI)

This study links diffusion MRI measures of optic nerve integrity to clinical glaucoma markers in patients using semi-automated tractography.

Silicone oil-induced ocular hypertension in mouse models glaucomatous neurodegeneration and neuroprotection

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.

Forecasting Future Humphrey Visual Fields Using Deep Learning

This study trains a deep learning model to predict future 24-2 Humphrey Visual Fields up to 5.5 years ahead using historical data from glaucomatous patients.

Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma

This study shows that increasing Ucp2 expression in retinal ganglion cells protects against glaucoma-induced cell death, but transcriptional activation alone is insufficient for neuroprotection.

Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in Glaucoma

This study shows that deleting UCP2 in mice reduces retinal ganglion cell death in glaucoma by increasing mitophagy and mitochondrial quality control.

Arginine to glutamine mutation in olfactomedin-like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed.

The paper identifies a missense variant in OLFML3 as a candidate for severe goniodysgenesis and glaucoma in Border Collies.

Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death

This study investigates the roles of MKK4 and MKK7 in retinal development and RGC death after axonal injury, finding that their deficiency increases RGC survival but disrupts retinal structure when both are absent.

Differential Susceptibility of Rat Retinal Ganglion Cell Subtypes Following Optic Nerve Crush

This study examines the differential loss of retinal ganglion cell subtypes after optic nerve crush in rats, finding that alpha- and direction selective-RGCs are more susceptible to loss compared to ip-RGCs.

Genome-wide Expression Profiling and Pathway Analysis in Cyclic Stretched Human Trabecular Meshwork Cells

This study identifies differentially expressed miRNAs and genes in human trabecular meshwork cells under cyclic mechanical stretch, highlighting miRNA-mRNA regulatory interactions in glaucoma-related pathways.

Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.