Cannabis and Cannabinoid Research

Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety

This study shows that deleting DAGLα in cerebellar Purkinje cells in mice leads to reduced social preference and increased anxiety.

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

This study investigates whether inhaled cannabidiol (CBD) can reverse fentanyl addiction and modulate neuroinflammation in a mouse model.

Oral cannabidiol administration in mice during pregnancy and lactation affects early postnatal body weight, fasting glucose, ingestive behavior, anxiety- and obsessive compulsive-like behaviors, and long-term object-memory in adult offspring in a sex-dependent manner

This study examines the effects of perinatal cannabidiol exposure on mice, finding sex-dependent impacts on metabolism, behavior, and survival.

A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies

This paper develops and characterizes RNB-61, a potent and selective CB2R agonist with favorable pharmacokinetics, showing nephroprotective effects in kidney injury models.

Priming lymphocyte responsiveness and differential T cell signaling in pediatric IBD patients with Cannabis use.

This study examines how chronic cannabis use affects immune cell function in pediatric IBD patients, finding increased pro-inflammatory cytokines and altered T cell signaling.

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

This study evaluates the effects of ZCZ011, a CB1R PAM, on behavior and the endocannabinoid system in HIV-1 Tat transgenic mice, showing sex- and genotype-dependent outcomes.

Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance

This study identifies primary sensory neurons as the cell type mediating anti-allodynic effects of CB2 agonists and reveals a sexually dimorphic sparing of morphine tolerance in male mice.

Charting the Cannabis plant chemical space with computational metabolomics

This study uses computational metabolomics to map the chemical diversity of Cannabis beyond cannabinoids, revealing distinct profiles in two cultivars and their potential medicinal properties.

Dorsomedial Striatum CB1R signaling is required for Pavlovian outcome devaluation in male Long Evans rats and reduces inhibitory synaptic transmission in both sexes

This study shows that CB1R signaling in the dorsomedial striatum affects Pavlovian outcome devaluation and inhibitory synaptic transmission, with sex differences observed in these effects.

Indirect and Direct Cannabinoid Agonists Differentially Affect Mesolimbic Dopamine Release and Related Behaviors

This study compares the effects of indirect and direct cannabinoid agonists on mesolimbic dopamine release and behaviors in mice, finding no abuse-related behaviors but suggesting direct CB1R agonism affects dopamine function more.

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress

This study shows that inhibiting cannabinoid type 2 receptors combined with physical exercise reduces stress-induced emotional and cognitive deficits and enhances adult hippocampal neurogenesis.

Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location

This study shows that cannabinoid receptor 1 (CB1) signaling depends on its subcellular location, which is controlled by promoters and N-terminal tags, and demonstrates a method to tag receptors without disrupting signaling.

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

This study identifies CB1R overactivation as a driver of CRBN deficiency-linked ARNSID and suggests CB1R blockade as a potential therapy.

Δ9-tetrahydrocannabinol (THC) Increases the Rewarding Value of Oxycodone During Self-Administration in Rats

This study shows that THC increases oxycodone self-administration in rats, suggesting it enhances opioid reinforcement and addiction risk.

Cannabinoid type-1 (CB1) receptors in glial cells promote neuromuscular junction repair following nerve injury.

This study investigates the role of CB1 receptors in glial cells during neuromuscular junction repair after nerve injury, finding that their blockade accelerates denervation and delays reinnervation.

Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation

This study identifies FAAH as a key regulator of adult mammary gland development by promoting luminal cell differentiation through endocannabinoid signaling.

Negative allosteric modulation of cannabinoid CB1 receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception

This study shows that the CB1 receptor NAM GAT358 reduces opioid tolerance and withdrawal without impairing analgesia in mice.

Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

This study shows that Δ9-THC exposure increases proliferation of naive mouse ESCs through CB1 receptor activation, with metabolic changes retained during differentiation to primordial germ cell-like cells.

Sex-specific Effects of the Endocannabinoid Agonist 2-Arachidonoylglycerol on Sleep and Circadian Disruptions during Fentanyl Withdrawal

This study examines how 2-AG affects sleep and circadian rhythms in male and female mice during fentanyl withdrawal, finding sex-specific effects on sleep disruption.

Discovery of Novel Small Molecule CB2 Agonist for the Treatment of Glioblastoma Tumors

This paper demonstrates that the CB2 agonist NTRX-07 significantly extends GBM mouse survival without prior radiotherapy or TMZ, and is safe in preclinical models.

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naive mice

This study shows that sub-chronic peripheral CB1R inhibition improves memory and executive function in mice and alters hippocampal synaptic plasticity and gene expression.

Exploring the Therapeutic Potential of Cannabis Constituents in Parkinson's Disease: Insights from Molecular Docking Studies

This paper uses molecular docking to evaluate cannabis compounds' neuroprotective effects against Parkinson's disease targets, finding cannabicyclol has a strong binding affinity for MAO-B.

Cannabinoid receptor type 2 expression in mouse brain: from mapping to regulation in microglia under inflammatory conditions

The paper maps CB2 expression in mouse brain and shows its regulation in microglia under different inflammatory conditions.

Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition

This study shows that a single cocaine dose impairs eCB-LTD and social behavior in mice, which can be reversed by FAAH inhibition.

Unravelling a novel role for Cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

This study investigates CBDV's effect on SVZ neurogenesis, showing it promotes neuronal differentiation and inhibits oligodendrocyte differentiation via TRPV1.

Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: a pilot study

This study examines CB1R levels in excitatory and inhibitory boutons in schizophrenia patients, finding increased CB1R in excitatory boutons and decreased in inhibitory ones, suggesting altered neurotransmission balance.

Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults

This study examines the effects of regular cannabis use on brain resting-state functional connectivity in adolescents and adults, finding localized increases in the executive control network in users but no significant age-group interactions.

Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

This study shows that adolescent THC exposure causes microglial apoptosis in the mPFC, which is worsened by 16p11.2 duplication, leading to social memory deficits via microglial Cnr1.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression

The paper shows that SGIP1 binding to the H9 domain of CB1R promotes axonal surface expression, which regulates presynaptic responsiveness.

Cannabidiol administration reduces the expression of genes involved in mitochondrial electron transport chain and ribosome biogenesis in mice CA1 neurons

This paper investigates the transcriptomic effects of CBD on CA1 neurons in mice, finding gene expression changes related to mitochondrial function and ribosome biogenesis after single and repeated administrations.