Psoriasis: Treatment and Pathogenesis

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model

This study shows fibulin 7 protects against skin inflammation by modulating IL-17A signaling in a psoriasis model.

Sensory neurons shape γδ T cell effector programs to control Psoriasiform Inflammation.

This study shows that sensory neuron subsets differentially modulate psoriasiform inflammation by shaping γδ T cell effector programs.

Disease context dictates the cellular targets of IL-17 in inflammatory skin disease

This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.

TNFR2 is Expressed by a Discrete Subset of Epidermal γ δ T Cells with an IL-17 Gene Signature during Psoriasis

The paper identifies TNFR2-expressing epidermal γδ T cells with an IL-17 gene signature in psoriasis, showing TNFR2's role in skewing these cells toward a Tγδ17 phenotype.

Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis

The paper identifies G-CSF produced by skin endothelial cells as a driver of pathological granulopoiesis and neutrophil infiltration in psoriasis, offering a potential therapeutic target.

Inhibition of eukaryotic translation initiation factor 1A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples

The paper inhibits eIF1A and eIF3B in psoriasis models, reducing inflammation and restoring skin health in mice and human 3D models.

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

This study identifies primulagenin A as a potent inverse agonist of RORγ, showing efficacy in inhibiting Th17 cell differentiation and reducing IL-17A production.

Psoriasis risk allele function in activated Th1/17 cells with "memory" to antigen exposure

The paper identifies a psoriasis risk allele that affects gene regulation specifically in memory Th1/Th17 cells, linking it to increased T cell activation during infection.

Drug screening identifies the Src/Abl inhibitor Dasatinib as suppressor of IL-23 signalling in skin inflammation

The paper identifies Dasatinib as a suppressor of IL-23 signaling in skin inflammation by blocking mTORC1 and mTORC2 activation in γδ17 T cells.

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Genetic liability to psoriasis predicts severe disease outcomes

This study identifies genetic risk factors associated with severe psoriasis and shows that polygenic risk scores can predict severe disease outcomes better than traditional risk factors.

Psoriasis-like inflammation induces structural and functional changes in mitochondria

This study examines how psoriasis-like inflammation affects mitochondrial structure and function in keratinocytes and fibroblasts, revealing cell-specific changes.

A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis

This study shows that A20's M1 ubiquitin binding motif suppresses TH17/22 cell activation and IL-22-driven enteritis by regulating RORγt and epigenetic changes in T cells.

FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development

This study shows that saturated fats drive psoriasis via FABP5-mediated IL-1β/IL-17 signaling in skin macrophages, exacerbating obesity-associated psoriasis.

Targeting dendritic cell-specific TNFR2 improves skin and joint inflammation by inhibiting IL-12/ IFN-γ pathways in a mouse model of psoriatic arthritis.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity

This study identifies PGAM as a negative regulator of Th17 pathogenicity using single-cell RNA-seq and metabolic flux analysis.

T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts

The paper shows how different T cell types drive distinct transcriptional changes in skin cells during inflammation, linking these changes to diseases like psoriasis and scleroderma.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

RTF1 mediates epigenetic control of Th17 cell differentiation via H2B monoubiquitination

This study shows RTF1 is essential for Th17 cell differentiation through H2B monoubiquitination, and its deficiency mimics the effects of RNF40 loss.

PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions

The paper identifies two tripeptide pharmacophores in PEPITEM and shows their engineered peptidomimetics reduce inflammation and immune cell infiltration in models of immune-mediated diseases.

Stiffness-dependent LOX regulation via HIF-1 drives extracellular matrix modifications in psoriasis

This study identifies stiffness-dependent LOX regulation via HIF-1 in psoriasis, linking ECM modifications to disease progression through mechanosensitive fibroblasts.

β2-Adrenergic Biased Agonist Inhibits the Development of Th17 and the Response of Memory Th17 Cells in an NF-κB-Dependent Manner.

This study shows that nebivolol, a β2-adrenergic biased agonist, suppresses IL-17A production by memory Th17 cells through a non-canonical β2AR signaling pathway involving NF-κB inhibition.

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

This paper conducts a genome-wide meta-analysis of palmoplantar pustulosis, identifying genetic associations with Th2 responses and cigarette smoking.

Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms

This study identifies 8 novel genetic risk loci for psoriasis and finds genetic correlations with socio-economic status and affective symptoms.

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

This study identifies eQTLs in psoriatic skin that are modulated by local inflammation, showing that gene regulation is primarily influenced by skin-specific factors rather than systemic variables.

The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis

This study integrates public transcriptomic data with network analysis to identify molecular features of psoriasis, revealing key genes and networks involved in the disease.

Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis

This paper develops a personalisable computational model of psoriasis that simulates immune interactions and predicts individual patient response to UVB therapy.

Transcriptomic profiling of plaque psoriasis and cutaneous T cell subsets during treatment with secukinumab

This study examines the effects of secukinumab on transcriptomic changes in psoriatic skin and T cell subsets over 12 weeks, showing significant reduction in IL17A and related genes.

Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes

The paper models cytokine and eicosanoid signaling in psoriatic keratinocytes to identify potential therapeutic targets and mechanisms of disease.