Adipokines, Inflammation, and Metabolic Diseases

Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity

This study shows that macrophage PARP1 depletion disrupts adipose tissue homeostasis by enhancing cell-cell crosstalk, leading to obesity and metabolic dysfunction.

A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice

A dietary intervention after stopping incretin analog therapy restores adipose tissue function and prevents weight regain in diet-induced obese mice.

Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

This study shows that deleting Dbc1 in adipocytes does not cause healthy obesity but reveals a role for Dbc1 in inflammation during obesity.

Identification of a specific set of genes predicting obesity before phenotype appearance

The paper identifies a set of genes whose expression predicts obesity susceptibility before symptoms appear, validated across species and tissues.

Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice

This study investigates the functional differences between thymic and peripheral Treg cells in visceral adipose tissue, showing that tTreg instability contributes to inflammation and obesity while pTreg cells protect against metabolic disorders.

Weight loss-induced adipose macrophage memory improves local Staphylococcus aureus clearance in male mice

This study shows weight loss in mice induces adipose macrophage memory that enhances local Staphylococcus aureus clearance but correlates with worsened diabetes risk upon weight regain.

Sex Differences in VEGF and PDGF Ligand and Receptor Protein Expression during Adipose Tissue Expansion and Regression

This study identifies sex-specific differences in VEGF and PDGF ligand and receptor profiles in adipose tissue during obesity progression and weight loss using a mouse model.

Modeling metabolic disease susceptibility and resilience in genetically diverse mice

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

Off-target genomic effects in MRP8-Cre driver mice complicate its use in weight gain and metabolic studies

This study shows that MRP8-Cre mice have off-target deletions affecting genes involved in thromboinflammation and metabolism, making them unsuitable for studying weight gain and metabolic disorders.

Are circulating levels of the myokine irisin linked to type 2 diabetes? A systematic review and meta-analysis

This study reviews and meta-analyzes 60 articles to assess if circulating irisin levels are linked to type 2 diabetes, finding inconsistent results and a trend of lower irisin in T2DM patients.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knock-out, and LacZ knock-in mice.

This study examines FAM19A5 expression and function in mice, finding low peripheral levels and no significant interaction with S1PR2.

Study of Plasma Adiponectin Levels in Patients with Metabolic Syndrome and Therapeutic Indication in Bangladesh

This study investigates plasma adiponectin levels in metabolic syndrome patients and suggests drug repurposing for adiponectin regulation.

Redox Signaling Mediates Differentiation of Adipose Progenitors in Response to Inflammatory Cytokines in the Adipose Tissue Secretome

This study identifies redox signaling and IL-6 as key regulators of adipogenesis in adipose progenitor cells under obesogenic conditions.

Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice

This study shows that CD163 deficiency in obese male mice worsens insulin sensitivity by promoting inflammation and iron dysregulation in adipose tissue macrophages.

Transcriptomic landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue

This study identifies sex-specific biomarkers and transcriptomic signatures in subcutaneous adipose tissue for obesity and T2D, highlighting sex differences in molecular mechanisms.

Application of novel 3D culture device for human omental adipocytes and macrophages derived from surgery

The paper introduces a novel 3D culture device for human omental adipocytes and macrophages derived from surgery to study post-surgical inflammation and morphological changes.

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

Targeting IRE1alpha improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.

HIF1α controls adipose tissue growth through metabolic rechanneling

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.

Sex-specific sequels of early life stress on serine/threonine kinase activity in visceral adipose tissue from obese mice

Interactome Analysis of Visceral Adipose Tissue Elucidates Gene Regulatory Networks and Novel Gene Candidates in Obesity

The paper constructs gene regulatory networks in visceral adipose tissue from obese and non-obese individuals, identifies altered network connectivity patterns, and validates novel gene candidates influencing adipocyte differentiation.

A Transcriptomic and Proteomic Atlas of Obesity and Type 2 Diabetes in Cynomolgus Monkeys

This study presents transcriptomic and proteomic analyses of obesity and T2D in cynomolgus monkeys, identifying tissue-specific molecular changes and potential therapeutic targets.

Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.

The paper identifies molecular and metabolic signatures of cardiometabolic syndrome using extreme phenotype groups and shows changes after bariatric surgery.

Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs

This study shows that deleting SLC7A8 in mice protects against diet-induced obesity by reducing lipid accumulation in multiple organs and improving glucose metabolism.

Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina

This study shows that reducing hypothalamic somatostatinergic neurons in mice leads to diabetes-like symptoms in multiple tissues without hyperglycemia.

Areca catechu-(Betel-nut)-induced whole transcriptome changes associated with diabetes, obesity and metabolic syndrome in a human monocyte cell line

The paper investigates transcriptome changes in human monocytes exposed to arecoline and MNPA, identifying genes linked to diabetes and obesity.

Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians

The paper investigates how an omentin gene polymorphism affects adiponectin levels and cardiometabolic health, finding adiponectin mediates this relationship in Asian Indians.

Regulators of TNFα Mediated Insulin Resistance Elucidated by Quantitative Proteomics

This study uses quantitative proteomics to identify regulators of TNFα-mediated insulin resistance in adipocytes under chronic inflammation.