Adipokines, Inflammation, and Metabolic Diseases

Extracellular GPX3 drives insulin receptor expression in adipose tissue independent of its peroxidase activity

This study identifies GPX3 as a paracrine mediator of adipose tissue insulin sensitivity through a GPX3-SP1-InsR signaling axis, independent of its peroxidase activity.

A Weight Loss Fibrotic Response in Visceral Fat Is Driven by Defective Lysosome-Dependent Collagenolysis

This study shows that weight loss fails to reverse visceral fat fibrosis due to impaired collagen degradation, suggesting ECM clearance enhancement as a therapeutic target.

SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease

This study shows that SOX4 reprograms adipose stromal cells into CAF-like cells in obesity, promoting metabolic disease through TGFβ and MDK signaling.

Metabolomics identifies endocannabinoid system remodeling during obesity associated inflammation in adipose tissue

The paper uses metabolomics to identify endocannabinoid system changes in adipose tissue during obesity-induced inflammation in mice.

SVEP1 couples adipose niche remodeling to macrophage activation and impaired metabolism in obesity

This study identifies SVEP1 as a key ECM protein involved in adipose remodeling, macrophage activation, and metabolic dysfunction in obesity.

Dynamic Responses to an Inflammatory Challenge Distinguish Metabolic Health Across Lean and Obese Individuals

This study shows that dynamic inflammatory responses, not static measures, better distinguish metabolic health across lean and obese individuals.

Uncovering a New Role of Dleu2/miR-15a/16-1 Cluster in Insulin Resistance and Obesity

This study identifies a new role of the Dleu2/miR-15a/16-1 cluster in obesity and insulin resistance, extending its biological significance beyond cancer.

Voluntary exercise during weight loss attenuates adipose CD8+ T cell exhaustion that persists after weight regain

This study shows that voluntary exercise during weight loss reduces adipose CD8+ T cell exhaustion, which persists even after weight regain, but does not improve glucose tolerance or macrophage inflammation.

Weight loss increases adipose dendritic cells, non-classical antigen presenting proteins, and cytotoxic effector cells

The paper examines how weight loss and weight cycling affect adipose tissue dendritic cells and immune responses in mice, finding increased dendritic cells and effector cells with weight loss.

Regulatory T cells establish an IL-10-IL10R immunometabolic checkpoint that limits HSL activation and lipolysis

This study identifies Tregs as an immunometabolic checkpoint that limits HSL activation and lipolysis via IL-10-IL10R signaling in adipose tissue.

The anatomical compartment defines distinct immune remodeling within human visceral adipose tissue during aging

The paper examines age-related immune changes in different visceral adipose tissue depots, finding depot-specific immune remodeling linked to adjacent organ function.

High-Intensity Interval Training Remodels Adipose Tissue Inflammatory Signaling and Enhances Immunometabolic Health via microRNA Regulation

This study shows that eight weeks of HIIT reduces adipose tissue inflammation and improves immunometabolic health in rats by modulating miRNA and gene expression.

Helminth infection induces RELMa-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesity

This study shows that helminth infection via RELM reduces diet-induced obesity by altering adipose tissue transcription and function in mice.

NgBR controls hepatic adiponectin signaling competence through KAT7-dependent chromatin regulation

This study identifies NgBR as a regulator of hepatic adiponectin sensitivity, showing that it maintains adiponectin receptor competence through KAT7-dependent chromatin regulation.

A conserved transcriptomic model defines metabolic resilience and vulnerability in obesity

The paper constructs a transcriptomic BMI model to identify molecular differences between metabolically healthy and unhealthy obesity in humans and validates it in mice.

T cell dysregulation and remodeling in pediatric obesity and weight loss

This study identifies T cell dysregulation in pediatric obesity and shows that these changes persist despite weight loss.

Senescent cells induce vascular MHC II to recruit CD4+ T cells and drive inflammation in aging adipose tissue

This study identifies senescent cells as drivers of age-related inflammation in adipose tissue by inducing vascular MHC II and recruiting CD4+ T cells through an IFN-gamma feedback loop.

Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease

This study shows that a 6-month lifestyle intervention reduces ER stress and inflammation while enhancing naive immune cell identity in older adults with metabolic disease.

Systematic variant-to-gene mapping highlights TGFB2 and VEGFA as adipokine-coding genes with non-obese, insulin-resistance-like characteristics and distinct disease risks

The paper maps adipokine-associated variants to effector genes across 1,669 traits, identifying TGFB2 and VEGFA as linked to insulin resistance and distinct disease risks.

Machine learning uncovers circulating biomarkers and molecular heterogeneity in obesity and type 2 diabetes

The paper uses machine learning on circulating proteomic data to identify biomarkers and reveal molecular subgroups in obesity and type 2 diabetes.

Myeloid Gi signaling acts as a weight-independent immunometabolic switch controlling systemic insulin sensitivity

This paper identifies myeloid Gi signaling as a weight-independent immunometabolic switch that regulates systemic insulin sensitivity through opposing cytokine programs.

Extracellular DNASE1L3 dysfunction fuels obesity-driven inflammation and metabolic syndrome

This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

Disulfiram Protects Against Diet-Induced Obesity by Reprogramming Systemic Lipid Partitioning Independent of GSDMD

This study shows Disulfiram protects against obesity and insulin resistance through GSDMD-independent mechanisms by reprogramming systemic lipid handling.

Deficiency of miR130a leads to fat hypertrophy, hepatic steatosis, insulin resistance and glucose intolerance in mice

Uncovering the function of Wisp1 in whole-body glucose homeostasis: insights from Wisp1 knockout mice

This study investigates the role of Wisp1 in glucose homeostasis using Wisp1 knockout mice, finding improved insulin sensitivity and reduced adipose inflammation but no effect on whole-body glucose tolerance.

Osteoprotegerin-Enabled Immune Evasion by Pathological Adipose Stromal Cells Drives Metabolic Dysfunction in Obesity

This study identifies senescent adipose progenitor cells (sAPCs) in obesity that produce osteoprotegerin (OPG), enabling immune evasion and metabolic dysfunction.

The inactivation of DHHC7 in mouse liver promotes diet-induced obesity through a hepatic Prg4-GPR146 axis

This study shows that inactivating DHHC7 in mouse liver leads to obesity via a Prg4-GPR146 axis, affecting adipose lipolysis and fat accumulation.

Non-canonical TERT function mitigates adipose tissue inflammation in obesity by modulating stem cell-macrophage communication and macrophage states

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

Licoisoflavone A improves adipose tissue dysfunction in response to diet induced obesity by promoting METTL3 expression

This study shows Licoisoflavone A improves adipose tissue dysfunction in obesity by increasing METTL3 expression, which helps with metabolism and inflammation.

Comparative Transcriptomic Analysis of Obesity and Lipodystrophy Reveals Shared Mechanisms and Novel Targets in Adipose Tissue Dysfunction

This study identifies a shared molecular signature in adipose tissue dysfunction across obesity and lipodystrophy, revealing common metabolic pathways and genetic loci associated with type 2 diabetes.