Genetics, Aging, and Longevity in Model Organisms

Predicting Mouse Lifespan-Extending Chemical Compounds with Machine Learning

This study uses machine learning to predict lifespan-extending compounds in mice by analyzing drug-target annotations, identifying key receptors and pathways associated with longevity.

Cross-Species Analysis Reveals No Universal Programmed Aging Mechanism: Insights from Single-Cell Transcriptomics in Zebrafish, Fruit Fly, and Nematode

This study uses single-cell transcriptomics across zebrafish, fruit fly, and nematode to show no universal programmed aging mechanism, finding species-specific gene regulatory patterns.

Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone

This study shows that gut neuropeptide F (NPF) and its interaction with brain insulin and juvenile hormone regulate Drosophila aging through interorgan communication.

Comparable anti-ageing efficacies of a multi-ingredient nutraceutical and a senolytic intervention in old mice

This study compares the anti-ageing effects of a multi-ingredient nutraceutical and a senolytic intervention in old mice, finding both extend lifespan similarly but differ in healthspan benefits.

Natural Variation in Age-Related Dopamine Neuron Degeneration is Glutathione-Dependent and Linked to Life Span

This study identifies glutathione deficiency as a key factor in age-related dopamine neuron loss and links it to lifespan in Drosophila, with implications for human Parkinson's disease.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Hyperactive mTORC1/4EBP1 Signaling Dysregulates Proteostasis and Accelerates Cardiac Aging.

This study shows that hyperactive mTORC1/4EBP1 signaling accelerates cardiac aging by dysregulating proteostasis in mice.

Loss of killifish cGAS/STING function attenuates cellular senescence and age-related signatures but does not extend organismal life span

This study shows that knocking out the cGAS/STING pathway in killifish reduces age-related cellular changes and inflammation but does not extend lifespan.

Aging-associated long non-coding RNA boosts longevity and reduces the ribosome content of non-dividing fission yeast cells

This study identifies a lncRNA, aal1, that extends lifespan in fission yeast by reducing ribosome content and protein translation, with similar effects observed in Drosophila.

Late-life short-term dietary restriction ameliorates intestinal stem cell function and impacts intestinal stem cell DNA methylation

This study shows that late-life short-term dietary restriction improves intestinal stem cell function and alters DNA methylation in aged mice.

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

Natural variations of cardiac performance in Drosophila identify a central function for Pdp1/dHLF in cardiac aging

The paper identifies genetic factors influencing cardiac aging in Drosophila by analyzing natural variation and highlights Pdp1's role in cardiac senescence through mitochondrial regulation.

Biology of healthy aging: Biological hallmarks of stress resistance-related and unrelated to longevity in humans

This study identifies 541 human genes associated with stress resistance and finds overlapping and distinct pathways with longevity, including PIP3-AKT-FOXO and mTOR, but also notes inconsistencies in pathway terminology.

Sedentary life accelerates epigenetic ageing in King penguins

This study shows that sedentary life in zoo-housed King penguins accelerates epigenetic ageing, similar to humans, linked to methylation changes in metabolic and heart-related pathways.

Systemic extracellular acidification is a hallmark of aging

This study identifies systemic extracellular acidification as a conserved aging hallmark in flies and mice, linking it to mortality and acidosis susceptibility.

High-dimensional Ageome Representations of Biological Aging across Functional Modules

This paper introduces Ageome, a framework to measure epigenetic age across molecular pathways in mice and humans, revealing pathway-specific aging patterns and heterogeneity in mortality prediction.

Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.

The paper shows that constitutive SKN-1 activation in C. elegans leads to serotonin deficiency, causing apathy toward pathogens and reduced survival.

Somatic Transthyretin-Related Proteins in C. elegans Govern Reproductive Longevity by Sustaining Sperm Integrity and Timely Ovulation

This study identifies three TTR paralogs in C. elegans that regulate reproductive longevity by maintaining sperm integrity and ovulation timing.

A male seminal fluid protein SFP-1 regulates hermaphrodite post-mating longevity and fat metabolism in Caenorhabditis elegans

This study identifies SFP-1 as a male seminal fluid protein in C. elegans that induces post-mating physiological changes by interacting with transcription factors in the intestine, leading to fat depletion and reduced lifespan.

Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood

This study develops a transcriptomic clock to predict age from whole blood and shows that physiological stress like COVID-19 can induce reversible age acceleration.

Directionality Theory and Mortality Patterns Across the Primate Lineage

The paper proposes the Entropic Principle of Longevity to explain human exceptional longevity by linking life-table entropy to ecological constraints and evolutionary history in primates.

Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila

This study investigates the stochastic effects of dietary restriction on lifespan in Drosophila, finding that DR does not universally extend lifespan and is influenced by genetic and stochastic factors.

A nuclear hormone receptor nhr-76 programs age-dependent chemotaxis decline in C. elegans

This study identifies nhr-76 as a genetic factor that programs age-dependent decline in chemotaxis behavior in C. elegans by downregulating odorant receptor expression.

Dietary zinc restriction mimics protein restriction and extends lifespan in Drosophila

This study shows that dietary zinc restriction in Drosophila extends lifespan and mimics the effects of amino acid restriction.

Cell cycle re-entry in the aging Drosophila brain.

This study examines how lifespan modifiers affect polyploidy accumulation in the aging Drosophila brain, finding that lifespan extension delays but does not prevent polyploid cell accumulation.

Stress responses and dynamic equilibrium: Key determinants of aging in the C. elegans clk-1 mutant

The paper models aging in C. elegans clk-1 mutants using Boolean networks and differential equations, identifying aak-2 as critical for lifespan extension through stress response regulation.

Robustness and variability in Caenorhabditis elegans dauer gene expression

The paper examines gene expression variability in Caenorhabditis elegans dauer larvae induced by different genetic or environmental triggers, finding transcriptional robustness in core pathways but variability in specific defense and metabolic pathways.

Aging clocks, entropy, and the limits of age-reversal

The paper analyzes DNA methylation and electronic health records to show aging is driven by entropy and configuration changes, with implications for age reversal.

ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.

Quantifying the Impact of Co-Housing on Murine Aging Studies

The paper assesses the impact of co-housing on lifespan studies in mice, showing that outcomes are correlated within housing units and highlighting limitations of standard statistical models.