Genetics, Aging, and Longevity in Model Organisms

Peroxiredoxin 2 Regulates DAF-16/FOXO Mediated Mitochondrial Remodelling in Response to Exercise that is Disrupted in Ageing

This study shows PRDX-2 regulates DAF-16/FOXO-mediated mitochondrial remodelling during exercise, which is disrupted in ageing in C. elegans.

Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans

This study shows that heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide extend C. elegans lifespan by improving proteostasis and immune responses through modulation of insulin-like signaling, autophagy-lysosome pathway, and antioxidant defenses.

Enhanced cellular longevity arising from environmental fluctuations

This study develops a mathematical model to analyze how environmental glucose fluctuations influence yeast aging and identifies strategies to enhance cellular longevity.

Phytoene and phytoene-rich microalgae extracts extend lifespan in C. elegans and protect against amyloid-beta toxicity in an Alzheimers disease model

Neuronal CBP-1 is required for enhanced body muscle proteostasis in response to reduced translation downstream of mTOR

This study shows that reducing translation in neurons or germline in C. elegans enhances muscle proteostasis and resilience to stress by increasing heat shock gene expression and muscle regulatory gene expression.

Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota

This study shows that low-dose cephaloridine induces colanic acid production in gut bacteria, extending host lifespan in C. elegans and mice.

Human reproduction comes at the expense of faster aging and a shorter life

This study finds that early childbearing, numerous pregnancies, and nulliparity are associated with accelerated aging and increased mortality risk in Finnish twin women.

High fat diet induces differential age- and gender-dependent changes in neuronal function linked to redox stress.

This study examines how a high-fat diet affects neuronal function in Drosophila, showing age- and gender-specific changes in oxidative stress and behavior.

Molecular Mechanisms of Genotype-Dependent Lifespan Variation Mediated by Caloric Restriction: Insight from Wild Yeast Isolates

This study identifies molecular factors and pathways associated with genotype-dependent lifespan variation in response to caloric restriction in wild yeast isolates.

Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants

This study shows that SKN-1 activity regulates lipid mobilization in C. elegans, affecting longevity and lipid distribution in response to genetic and environmental factors.

Natural variation in phospholipase IPLA2-VIA contributes to starvation sensitivity in Drosophila melanogaster

The paper identifies a genetic locus, iPLA2-VIA, contributing to starvation sensitivity in Drosophila by analyzing mitonuclear genotypes and metabolic changes.

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

The germline coordinates mitokine signaling

The paper shows that germline mitochondria mediate neuron-to-peripheral UPRMT signaling in C. elegans by responding to mitokines like WNT and serotonin and regulating lipid metabolic pathways.

Mitochondrial maintenance is involved in the exceptional longevity of reproductive queens of the eusocial ant Lasius niger

This study investigates mitochondrial bioenergetics and oxidative stress in queens of Lasius niger, finding that their longevity is associated with better mitochondrial maintenance rather than reduced oxidative damage.

Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control

This study shows that aneuploidy in yeast causes premature aging by disrupting ribosome quality control, leading to protein aggregates and cyclin dysregulation.

Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster

This study investigates how developmental and adult diet composition affects reproductive aging in Drosophila melanogaster, finding age-dependent impacts with independent effects of developmental and adult diets.

The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction.

This study identifies the transcriptional response to dietary restriction in C. elegans and shows that MML-1::MXL-2 and PHA-4 have distinct roles in mediating the physiological benefits of DR.

Knockout of the longevity gene Klotho perturbs aging- and Alzheimer's disease-linked brain microRNAs and tRNA fragments

This study shows that Klotho knockout affects brain microRNAs and tRNA fragments linked to aging and Alzheimer's disease in both mice and humans.

Kinome-wide RNAi screen in Caenorhabditis elegans reveals new modulators of insulin signaling and longevity

This study identifies new kinases modulating insulin signaling and longevity in C. elegans through a kinome-wide RNAi screen, revealing correlations between thermotolerance, dauer formation, and lifespan extension.

Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity

The paper uses plasma proteomics from the UK Biobank to estimate organ age and links it to disease risk and longevity.

Genome-wide temporal gene expression reveals a post-reproductive shift in the nematode C. briggsae

The paper identifies a post-reproductive gene expression shift in C. briggsae through transcriptomic analysis, revealing distinct biological process enrichments before and after reproduction.

Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate

This study profiles protein aggregation in seven tissues of aging killifish, revealing tissue-specific patterns linked to protein biophysics and quality control.

Identification of protein aggregates in the aging vertebrate brain with prion-like andphase separation properties

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults

The paper develops a proteomic aging clock (PAC) that predicts all-cause mortality and disease outcomes in middle-aged and older adults using plasma protein data.

The killifish germline regulates longevity and somatic repair in a sex-specific manner

This study shows that germline manipulation in killifish leads to sex-specific effects on longevity and repair mechanisms.

Enhancing autophagy by redox regulation extends lifespan in Drosophila

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging

This study identifies TGFβ and serotonin signaling pathways that regulate oocyte precursor proliferation and germline aging in C. elegans.

Functional and multi-omic aging rejuvenation with GLP-1R agonism

This study shows GLP-1R agonism reduces age-related molecular changes in mice, with effects on multiple omic levels and organ-specific rejuvenation.

In vivo reprogramming of Caenorhabditis elegans leads to heterogeneous effects on lifespan

This study induces in vivo reprogramming in C. elegans and finds it leads to heterogeneous effects on lifespan depending on developmental stage.

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.