Genetics, Aging, and Longevity in Model Organisms

Dietary zinc limitation dictates lifespan and reproduction trade-offs of Drosophila mothers

This study shows that dietary zinc limitation in Drosophila affects reproduction without reducing lifespan, highlighting its role in resource allocation between fitness traits.

Fisher Information and the Dynamics of Multicellular Aging

This paper introduces a theoretical model using Fisher information to explain multicellular aging dynamics, showing non-monotonic behavior based on competition and cooperation balance.

Comprehensive evaluation of lifespan-extending molecules in C. elegans

This study evaluates 16 lifespan-extending molecules in C. elegans, confirming some effects, identifying synergies, and finding conserved effects in Drosophila.

Developmental and conditional regulation of DAF-2/INSR ubiquitination in Caenorhabditis elegans

The paper shows that DAF-2/INSR ubiquitination by CHN-1/CHIP regulates IIS differently in larvae and adults, and under varying temperature and nutrient conditions.

Ketone body b-Hydroxybutyrate does not extend lifespan, but upregulates fecundity in food-limited Daphnia, with a transgenerational effect

This study shows that b-hydroxybutyrate reduces lifespan but increases fecundity in Daphnia magna, with a transgenerational effect dependent on genotype.

Mitochondrial superoxide acts in the intestine to extend longevity

This study shows that reducing mitochondrial superoxide in the intestine extends longevity in worms by improving stress resistance.

Chameau (HBO1) regulates starvation in a temperature-dependent manner in Drosophila melanogaster

This study shows that Chameau (HBO1) enhances starvation resilience in Drosophila melanogaster at lower temperatures, but its role diminishes at higher temperatures.

High-throughput assessment of exercise-induced adaptations and muscle function in health and ageing

The paper introduces ClimbMaster, an automated platform to assess exercise-induced adaptations in Drosophila, showing exercise improves endurance, fat loss, and insulin sensitivity, and rapamycin mitigates age-related decline.

Modulation of cellular ageing regulates Integrated Stress Response signalling to control blood cell homeostasis

This study investigates how modulating cellular ageing affects blood cell homeostasis in Drosophila larval lymph glands by examining the role of the Integrated Stress Response pathway.

Oxidative stress promotes axonal atrophy through alterations in microtubules and EB1 function

This study shows oxidative stress causes axonal atrophy by altering microtubules and EB1 function, and suggests targeting EB1 could prevent age-related neuronal decline.

Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice

This study compares age-related decline and behavioral validity in C57BL/6 and CB6F1 mice, finding strain-specific differences in behavior, physiology, and organ pathology.

Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons

This study shows that reduced collagen in non-neuronal tissues drives specific aging-related changes in sensory neurons, independent of collagen's structural role.

The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

Longitudinal Decline of Exercise Capacity in Male and Female Mice

This study tracks longitudinal changes in exercise capacity and physical function in male and female mice using CFAB, finding sex-specific declines in function and body composition.

The CALERIE™ Genomic Data Resource

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

Kolmogorov-Smirnov and Shapiro-Wilk single distribution analysis methods in examining sample structure, strength of genetic background, and effects of interventions in lifespan and aging studies

The paper applies Kolmogorov-Smirnov and Shapiro-Wilk tests to analyze sample structure and genetic background effects on lifespan and aging.

Knockout of all nematode-specific NSPC genes expressed exclusively in the excretory gland cell results in transcriptomic signatures indicating an affected insulin signaling

The paper investigates the role of nematode-specific NSPC genes in C. elegans, finding that their deletion affects insulin signaling rather than defense response.

Discovery of Thermodynamic Control Variables that Independently Regulate Healthspan and Maximum Lifespan

The paper identifies thermodynamic control variables that regulate healthspan and maximum lifespan using DNA methylation data from mammals.

Blood Omics Models for System-Specific Mortality Risk Estimation

The paper develops mortality-based predictors of biological age for 9 physiological systems using blood data from the UK Biobank and validates them in the Health and Retirement Study.

Comparative lifespan and healthspan of nonhuman primate species common to biomedical research

This study computes sex-specific survival curves for 12 nonhuman primate species to characterize aging patterns and provides insights into lifespan and healthspan differences.

Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan

The paper uses deep learning to predict replicative lifespan in yeast by analyzing metabolic flux distributions and identifies a core network of reactions that explain lifespan variance.

Searching for Jouvence SnoRNA in the Horse Genome

This study identifies a putative Jouvence snoRNA gene in the horse genome and finds its expression increases in ageing equine cartilage.

Histological aging signatures enable tissue-specific disease prediction from blood

This paper develops tissue clocks from histopathological images to predict biological age and disease risk from blood samples, showing non-uniform aging rates across tissues and associations with lifestyle and medical factors.

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity

The paper shows that prg-1 mutant C. elegans germ cells transmit heritable stress that promotes longevity but reduces fertility, with effects observed in F1 progeny.

The abundance change of age-regulated secreted proteins affects lifespan of C. elegans

The study identifies age-regulated secreted proteins in C. elegans that affect lifespan when their abundance is altered, suggesting their role in proteostasis and aging.

Mechanical load conditions the spectrin network to `run-on' proteolysis and promotes early onset neurodegeneration

This study shows that age-related loss of proprioception in C. elegans is linked to spectrin cytoskeleton degradation due to mechanical stress and calcium-sensitive proteolysis, which can be mitigated by chaperone expression.

Methuselah Proteins in Longevity: Unraveling Their Impact Through Mathematical Genomics

This study analyzes 18 Methuselah protein variants in fruit flies, identifying evolutionary clades, functional subclasses, and structural features related to aging and longevity.

Sodium Benzoate Promotes Fat Accumulation and Aging via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model

This study shows sodium benzoate increases fat accumulation and accelerates aging in C. elegans by inhibiting the SKN-1/Nrf2 signaling pathway.

Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review

This review analyzes 435 biological aging papers to show trends in molecular markers and new metrics, and identifies consistent and conflicting findings.

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.