Atherosclerosis and Cardiovascular Diseases

The multifaceted process of human coronary atherosclerotic cap destabilisation

This study maps the qualitative changes in coronary atherosclerotic cap characteristics during lesion progression and destabilization using a pseudo-timeline approach.

Serum amyloid A3 deficiency modulates aortic immune composition and attenuates murine atherosclerosis progression

This study shows that Saa3 deficiency reduces atherosclerosis in mice by altering aortic immune cell composition and function.

Single-cell multimodal profiling of atherosclerosis identifies CD200 as a lineage marker of vascular smooth muscle cells and their derived cells

The paper identifies CD200 as a specific marker for vascular smooth muscle cells and their derived cells in atherosclerosis using CITE-seq and validates it across multiple techniques.

Development and implementation of an integrated preclinical atherosclerosis database

The paper develops an integrated preclinical atherosclerosis database by extracting data from mouse models and provides tools for standardized analysis and integration with transcriptomics software.

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risks

The paper uses multimodal single-cell profiling to identify diverse monocyte subtypes and links them to cardiovascular disease risk factors.

Oleic acid triggers CD4+ T cells to be metabolically rewired and poised to differentiate into proinflammatory T cell subsets upon activation

This study shows that oleic acid pre-exposure rewires CD4+ T cell metabolism, promoting pro-inflammatory differentiation upon activation.

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosis

The paper integrates single-cell RNA-seq and spatial transcriptomics data to reveal cellular interactions and changes in human atherosclerosis.

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

This study performs a meta-analysis of scRNA-seq datasets to map human atherosclerosis cell diversity and identifies disease-relevant vascular cell states and markers.

Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease.

The paper identifies a novel macrophage subpopulation, lipid-handling macrophages, that is enriched with CAD genetic risk and shows how a risk variant affects FDX1 through AP-1 and C/EBP-beta recruitment.

Cyclophilin D induces necrotic core formation by promoting mitochondria-mediated macrophage apoptosis in advanced atherosclerotic lesions

This study shows that CypD promotes macrophage apoptosis and necrotic core formation in atherosclerosis by affecting mitochondrial function and inflammation.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

Network preservation analysis reveals dysregulated metabolic pathways in human vascular smooth muscle cell phenotypic switching

The paper identifies dysregulated metabolic pathways in vascular smooth muscle cells during phenotypic switching and links them to atherosclerosis.

INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10

This paper identifies INKILN, a human-specific lncRNA that promotes vascular smooth muscle inflammation by stabilizing MKL1 and interacting with USP10.

Single cell omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveals heterogeneity of endothelial subtype and response to activating perturbations

This study profiles human aortic endothelial cells in vitro and atherosclerotic lesions ex vivo, revealing heterogeneous subtypes and their responses to perturbations.

Single-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

The paper uses single-cell time-resolved multi-omics to reveal apoptotic and ferroptotic heterogeneity in macrophage-derived foam cells during atherosclerosis progression.

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis

The paper uses proteogenomic integration to identify CXCL10 as a mediator of IL-6 signaling effects on atherosclerosis, showing its association with cardiovascular disease risk and lesion characteristics.

Molecular mechanisms of coronary artery disease risk at the PDGFD locus

This study identifies PDGFD as a CAD risk gene, showing it promotes SMC expansion, migration, and inflammation, contributing to vascular calcification and plaque recruitment.

Single-cell RNA sequencing reveals aortic cellular heterogeneity in MSC_ITGB3-treated ApoE-/- mice on a high-fat diet

This study uses single-cell RNA sequencing to analyze aortic cellular composition and responses in mice under high-fat diet and MSC_ITGB3 treatment, revealing changes in cell types and signaling pathways.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression

This study shows that targeting scavenger receptors Stabilin-1 and Stabilin-2 reduces atherosclerosis by altering the plasma proteome, which suppresses monocyte/macrophage activity.

Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice

The paper shows that loss of PRMT2 in myeloid cells impairs atherosclerosis regression in normoglycemic mice, mimicking diabetic conditions, through increased inflammation and macrophage dysfunction.

A multiple comorbidities mouse model to assess atherosclerosis progression following lung infection in ApoE deficient mice

This paper develops a mouse model to study how bacterial pneumonia affects atherosclerosis progression in ApoE-deficient mice through systemic inflammation.

Ablation of SAMD1 in Mice Causes Failure of Angiogenesis, Embryonic Lethality

This study shows that SAMD1 ablation in mice leads to embryonic lethality and failure of angiogenesis, suggesting a critical role in vascular development.

Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women.

Allosteric MAPKAPK2 Inhibitors Improve Plaque Stability in Advanced Atherosclerosis

This study shows that MK2 inhibitors TBX-1 and TBX-2 improve glucose metabolism and reduce atherosclerotic plaque instability in mice with established atherosclerosis.

Inhibiting LXRα Phosphorylation in Hematopoietic Cells Reduces Inflammation and Attenuates Atherosclerosis and Obesity

This study shows that inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and improves atherosclerosis and obesity by altering macrophage and adipose tissue gene expression.

SVEP1, a novel human coronary artery disease locus, promotes atherosclerosis

This study identifies SVEP1 as a novel coronary artery disease locus that promotes atherosclerosis by affecting vascular smooth muscle cell function and signaling pathways.

Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans

The paper identifies a genetic variant associated with increased carotid plaque vulnerability but not with cardiovascular disease risk in humans.

The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions

The paper investigates the role of AHR in atherosclerosis by showing it suppresses chondrogenic fate of modulated smooth muscle cells in lesions.

Decoding the transcriptome of atherosclerotic plaque at single-cell resolution

The paper analyzes single-cell transcriptomes of atherosclerotic plaques and adjacent tissue to identify gene drivers of cellular transdifferentiation and inflammatory processes.