F. Li

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

A single-cell survey of Drosophila blood

This study uses scRNA-seq to analyze Drosophila hemocytes under inflammatory conditions, revealing new states and a role for FGF signaling in immune responses.

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Life history recorded in the vagino-cervical microbiome

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

HMGB1 mediates the development of tendinopathy due to mechanical overloading

This study shows that HMGB1 release in response to mechanical overloading causes inflammation and tendinopathy in mice, which can be blocked by glycyrrhizin.

Crif1 Promotes Osteoporosis in Mice after Radiation

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

Lung tumour cell-derived exosomes promote the expansion of MDSC through miR-21a/PDCD4/IL-6/STAT3 pathway

This study shows lung cancer exosomes promote MDSC expansion via miR-21a/PDCD4/IL-6/STAT3 pathway, enhancing tumor growth.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

Contributions to human breast milk microbiome and enteromammary transfer of Bifidobacterium breve

The paper investigates the origin of breast milk microbes and identifies Bifidobacterium breve transmission via the enteromammary pathway in a C-section infant.

PRR14 Overexpression Promotes Cell Growth, Epithelial to Mesenchymal Transition and Metastasis of Colon Cancer via the AKT Pathway

Myosin II Tension Sensors Visualize Force Generation within the Actin Cytoskeleton in Living Cells

The paper introduces a FRET-based tension sensor to measure forces generated by NMIIB in living cells, revealing spatial and temporal heterogeneity in cytoskeletal forces.

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

The paper creates a gene catalog of bovine rumen microbes, revealing high diversity and function in plant biomass degradation and methane production.

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

Impacts of diets fed after weaning on gut microbiota and susceptibility to DSS-induced colitis in mice

This study examines how different diets after weaning affect gut microbiota and susceptibility to DSS-induced colitis in mice, finding that high protein diets worsen colitis while high fiber diets reduce it.

MiR-590-5p sensitises pancreatic ductal adenocarcinoma cells by blocking autophagy via targeting ATG3

This study shows miR-590-5p reduces radio-resistance in pancreatic cancer by inhibiting autophagy through targeting ATG3.

FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

FabriEVEs is a database that collects, classifies, and annotates endogenous viral elements in non-mammalian species, enabling comparative analysis and host-virus co-evolution studies.

Compartmentalized Biosynthesis of Mycophenolic Acid

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species

The paper examines resistance to Puccinia coronata f. sp. avenae in Brachypodium species, finding race-specific responses independent of ROS and involving salicylic acid and ethylene signaling.

Effects of exclusive breastfeeding on infant gut microbiota: a meta-analysis across studies and populations

This study meta-analyzes seven studies to show that exclusive breastfeeding increases gut microbiota diversity and specific metabolic pathways while reducing others, with benefits persisting beyond six months.

Genome sequence of a diabetes-prone desert rodent reveals a mutation hotspot around the ParaHox gene cluster

The paper sequences the genome of a diabetes-prone desert rodent and identifies a mutation hotspot around the ParaHox gene cluster, including the Pdx1 gene, showing extreme divergence due to GC-biased mutation.