X. Lu

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

A cataract-causing Y204X mutation of CRYβB1 promotes C-terminal degradation and higher-order oligomerization

This study identifies a cataract-causing mutation in CRYβB1 that leads to C-terminal truncation, increased proteolysis, and higher-order oligomerization, contributing to lens opacity.

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck Cancers

This study uses spatial-omics to identify tumor metabolic states and immune cell profiles in OPSCC, leading to insights on ICI failure and potential drug targets.

Dormancy-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis

The paper identifies a mechanosensitive FHL2-p21 signaling axis in dormant cancer cells using 3D-engineered matrices, showing its role in drug resistance and potential as a target for therapy.

Chiral Graphene Quantum Dots Enhanced Drug Loading into Exosomes

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

A Theory for High-Throughput Genetic Interaction Screening

This paper introduces a theory for high-throughput genetic interaction screening using spectrally unique barcodes from fluorescent proteins, enabling genome-scale genetic perturbation studies.

DNA capture and loop extrusion dynamics by cohesin-NIPBL

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and efficacy to the Omicron variant.

Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal-end

The paper shows that CP110 and Cep97 at the distal end of centrioles influence cartwheel growth at the proximal end through interactions with Plk4 oscillations.

Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle

This study shows marine picocyanobacteria utilize chitin, linking their planktonic lifestyle evolution to chitin degradation and ecological expansion.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

CvkR, a novel MerR-type transcriptional regulator, is a repressor of class 2 type V-K CRISPR-associated transposase systems

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

A full spectrum PNGase activity analysis of R328 mutations on NGLY1

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

Engineering bacterial blight-resistant plants through CRISPR/Cas9-targeted editing of the MeSWEET10a promoter in cassava

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

Arbidol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

Reconstructing phylogeny of the hornless rhinoceros Aceratheriinae

This paper presents the first phylogenetic analysis of the subfamily Aceratheriinae, reclassifying tribes and identifying early diverging taxa based on morphological characteristics.

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

Single-cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

The runaway evolution of SARS-CoV-2 leading to the highly evolved Delta strain

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

RNA2Immune: A Manually Curated Database of Experimentally Supported Data Linking Noncoding RNA Regulation to the Immune System

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

A novel Phytophthora sojae effector PsFYVE1 modulates transcription and alternative splicing of immunity related genes by targeting host RZ-1A protein

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

Nrf2 mediated ER-phagy protects against oxidative damage in intervertebral disc degeneration

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.