Cancer Immunotherapy and Biomarkers

An immunosuppression imaging gauge prospectively predicts metastatic progression and immunotherapy resistance in breast cancer

This paper develops an imaging-based immunosuppression gauge to predict metastatic progression and immunotherapy resistance in breast cancer by tracking CXCR2-expressing cells.

Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC

This study identifies glutamine metabolism as a key mechanism limiting T cell infiltration and function in HNSCC, showing that targeting glutaminase-1 enhances immune response.

Spatial immune profiling reveals lymphocyte confinement to myeloid-mesenchymal niches and heterogeneous therapeutic T-cell opportunity in pediatric ependymoma

The paper uses spatial transcriptomics to analyze immune infiltration in pediatric ependymoma, revealing compartmentalized immune niches and heterogeneous T-cell therapy opportunities.

Mutanome-guided immunopeptidomics of blood plasma for neoepitope detection in solid tumors is constrained by cfDNA variant calling sensitivity and MS detection limits

The paper uses plasma immunopeptidomics guided by mutanomes to detect neoepitopes in solid tumors, finding that cfDNA variant calling sensitivity and MS detection limits constrain plasma-based detection.

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

This study identifies a tumor-cell MHC-II program linked to immunotherapy outcomes in bladder cancer across different stages and treatment settings.

Cross-species spatial profiling links progranulin to an immune suppressive niche in brain metastasis

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

Predicting Neoantigen Immunogenicity from In Vivo Immune Editing

This paper introduces NEMo, a machine learning model that predicts neoantigen immunogenicity using in vivo immune editing data, showing improved stratification of progression-free survival across multiple clinical settings.

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

Mitochondrial genetics defines anti-tumour immunity through mitochondrial ROS and PD-1 signalling

This study shows mitochondrial haplogroups affect tumour growth and anti-tumour immunity through mitochondrial ROS and PD-1 signalling in mouse models.

γδ T cells modulate anti-tumor immunity in small cell lung cancer

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

Spatially resolved multimodal hallmarks of response to neoadjuvant immunotherapies in the melanoma ecosystem in 2D and 3D

The paper analyzes the spatial molecular architecture of melanoma tumors under different immunotherapy regimens and identifies biomarkers predicting response to treatment.

JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

This paper investigates JAK-STAT pathway heterogeneity in breast cancer and finds that high JSP activity correlates with improved immunotherapy response, particularly in triple-negative breast cancer.

C1q from C1q+ tumor-associated myeloid cells promotes resistance to T-cell engagers and CAR T-cells and is induced by LIF and glucocorticoids

This study identifies C1q from C1q+ tumor-associated myeloid cells as a key immunosuppressive factor in glioblastoma that impairs T-cell engagers and CAR T-cell efficacy, induced by LIF and glucocorticoids.

A frozen human wound-repair reference reveals heterogeneous tumor niches and conditional immunotherapy associations

The paper analyzes wound-repair modules in tumors to identify heterogeneous niches and conditional immunotherapy associations.

Dendritic cell PD-L2 restrains intratumoral CD8+ T cell immunity

This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.

Distinct Spatial Immune Architectures in Tumor and Tumor-Adjacent Tissues of Early-Stage Non-Small Cell Lung Cancer

This study compares spatial immune architectures in tumor and tumor-adjacent tissues of early-stage NSCLC, finding distinct immune cell densities, spatial patterns, and associations with genomic features and patient outcomes.

Patient-derived IgG Amplifies Fcγ Receptor-Dependent Colonic Inflammation During Immune Checkpoint Blockade

The paper shows that patient-derived IgG from those with severe immune-related colitis amplifies inflammation during immune checkpoint blockade in humanized FcγR mice.

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

This study identifies Streptococcus anginosus as a gastric cancer driver that uses a chromatin remodeler to reprogram host epigenomes and promote immune evasion.

Baseline intratumoral TCRbeta; and TCRgamma; repertoires predict response to immune checkpoint inhibitors in advanced renal cell carcinoma

This study identifies baseline intratumoral TCRβ and TCRγ repertoire features as predictors of response to immune checkpoint inhibitors in advanced RCC.

Targeting the Myeloid Immune Checkpoint ILT3 (LILRB4) with Small Molecules Enables Reprogramming of Suppressive Tumor Immunity

This study identifies small molecule modulators of ILT3, a myeloid immune checkpoint, showing anti-tumor efficacy in preclinical models.

Attenuated Salmonella-Mediated Delivery of GSDMD Potentiates PD-1 Blockade Therapy against Melanoma

This study combines attenuated Salmonella-delivered GSDMD with anti-PD-1 therapy to enhance anti-melanoma immune responses in mice.

Integrative single cell analysis of CD8+ T-cells across early and advanced oral cancers reveals signatures of anti-tumour activity

This paper identifies a signature of anti-tumour activity in CD8+ T-cells across oral cancers using single-cell RNA and TCR sequencing, and develops a machine learning classifier to detect these cells from transcriptome data.

Differential peripheral immune dynamics underlie therapeutic response to chemotherapy and chemo-immunotherapy in triple-negative breast cancer

The paper identifies distinct immune states in TNBC patients based on treatment and response, linking peripheral immune dynamics to therapeutic outcomes.

Tumor γδ T-cell abundance is associated with favorable cancer treatment outcomes

This study finds that higher pretreatment γδ T-cell abundance is linked to better outcomes in cancer patients receiving immune checkpoint blockade and improved survival across multiple tumor types.

A Visually Interpretable Histopathology-Based Immune Model Predicts T-effector Biology and Response to Immune checkpoint inhibition in Clear Cell Renal Cell Carcinoma Clinical Trial and Contemporary Real-World Datasets

The paper develops a deep learning model from H&E images to predict T-effector biology and ICI response in ccRCC, showing strong correlation with RNA-based scores and clinical outcomes.

The Y chromosome gene KDM5D restrains CD8+ T cell antitumor immunity through TCR and cholesterol-exhaustion programs

This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

Immune-metabolic-redox ecosystems define spatially organized tumor states in head and neck squamous cell carcinoma.

The paper reanalyzes spatial transcriptomic data to define immune-metabolic-redox ecosystems in HNSCC, identifying a Hot+IMREShigh state associated with immune activation and stress adaptation.

Multiple mechanisms regulate the nanoscale organization of PD-L1 at the cell surface

This study investigates how PD-L1 is organized into nanoscale clusters on tumor cell surfaces and identifies actin cytoskeleton, galectin-3, and cholesterol as key regulators of its spatial arrangement and function.