Cardiac electrophysiology and arrhythmias

Nanoscale numerical simulations explain apparently opposing experimental findings on ephaptic coupling

The paper uses simulations to explain conflicting experimental results on ephaptic coupling in cardiomyocytes by analyzing geometric configurations.

Methodologies for Manipulating Cardiomyocyte Physiology: In Vitro and In Vivo Perspectives

This study develops and applies methodologies to manipulate cardiomyocyte physiology in vitro and in vivo, revealing effects of optogenetic and chemogenetic tools on heart rate and calcium dynamics.

Desmin p.R406W mutation is associated with arrhythmias through structural and electrophysiological remodeling

This study investigates the pathogenic effects of the DES p.R406W mutation, showing it causes electrical and structural heart remodeling linked to arrhythmias and sudden cardiac death.

Impaired S-nitrosylation of Cx43 prevents arrhythmogenicity and myocardial injury upon cardiac stress in Duchenne Muscular Dystrophy

This study shows that reducing S-nitrosylation of Cx43 in DMD mice prevents arrhythmias and myocardial injury under cardiac stress.

AAV9-mediated βIII-tubulin Ser172 phospho-mimic expression improves arrhythmic and inflammatory remodeling in dystrophic cardiomyopathy

This study shows that AAV9-mediated expression of phospho-mimic βIII-tubulin in dystrophic hearts reduces inflammation and improves Cx43 organization but not all cardiac pathologies.

Transcriptional regulation of the TASK-1 potassium channel by ETV1 -Implications for atrial excitability

This study shows ETV1 directly regulates TASK-1 expression and contributes to atrial electrical remodelling, suggesting ETV1 as a potential therapeutic target for atrial fibrillation.

Steroid sulfatase deficiency increases the frequency and persistence of ventricular arrhythmias in mice

This study shows that STS deficiency in mice increases ventricular arrhythmia frequency and persistence under baseline and stress conditions.

Structural and functional heterogeneity in cardiac RyR signalling nanodomains revealed with quantitative single molecule mapping toolkit

The paper develops a toolkit to map RyR2 and JPH2 nanodomains in cardiac cells, revealing spatial heterogeneity in their organization and function in right ventricular failure.

Patient-Specific Heart Rate Modulates Developmental Electrophysiology in Transcriptomic-Guided In Silico Models of Pediatric Human Atrial Cardiomyocytes

This study integrates patient-specific heart rates into computational models of pediatric atrial cardiomyocytes to show how developmental changes and pacing rates jointly influence electrophysiological biomarkers.

A broad set of synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG

This study investigates how synthetic cannabinoid receptor agonists affect cardiac ion channels, finding that most inhibit hERG and some also inhibit KV7.1/KCNE1.

A novel multicellular model of the adult mouse sinoatrial node retains spontaneous electrical activity and enables live investigation of the S100B-associated cell population

Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.

Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest

This study shows cardiac pacemaker cells use stochastic resonance to maintain rhythm at low heart rates, improving reliability in noisy conditions.

Whole-genome sequencing implicates rare, low-frequency and structural non-coding variation at the SCN5A locus in Brugada syndrome

This study identifies rare and low-frequency non-coding variants at the SCN5A locus associated with Brugada syndrome using whole-genome sequencing and functional assays.

Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome

This study shows that elevated temperature worsens arrhythmia and seizures in a zebrafish model of Timothy syndrome, suggesting fever may increase risk for TS patients.

In Silico Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic Burden

This study uses multiscale modeling to identify anti-arrhythmic strategies for cell therapy in infarcted human ventricles, showing that blocking specific currents and upregulating others reduces arrhythmias while maintaining calcium function.

Cardiomyocytes possess an intrinsic catecholaminergic machinery that regulates cellular homeostasis and electrophysiological stability

This study identifies an intrinsic catecholaminergic system in cardiomyocytes that regulates homeostasis and electrophysiological stability, with disruption leading to arrhythmias and metabolic dysfunction.

PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure

This study shows that neprilysin cleavage of phospholamban disrupts SERCA function in heart failure, contributing to cardiac dysfunction.

Stress Granule Coarsening Is a Pathological Inflection Point for Cardiac Electrophysiological Dysfunction

The paper identifies stress granule coarsening as a critical factor in cardiac electrophysiological dysfunction under oxidative stress.

Concealed Conduction Vulnerability in Scn1b Haploinsufficiency Emerges with Osmotic Stress

This study shows that Scn1b haploinsufficiency causes structural changes in cardiac intercalated discs that increase sensitivity to osmotic stress, unmasking concealed conduction abnormalities.

A Brugada-related KCNT1 mutation unveils its conductance-independent activation of store-operated Ca 2+ entry

This paper investigates the role of KCNT1 mutations in Ca2+ homeostasis and cardiomyocyte function, showing that its cytoplasmic tail modulates ER-PM contacts and Ca2+ dynamics independently of its ion-conducting function.

Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

AI-enhanced cardiac digital twins extend drug proarrhythmic risk assessment through experimental data uncertainty propagation and overdose exploration: a loperamide case study

The paper uses AI-enhanced cardiac digital twins to assess drug proarrhythmic risk by propagating experimental uncertainty and simulating extreme exposures, finding sex-specific arrhythmogenic thresholds for loperamide.

Serotype-dependent bioenergetic and electrophysiological remodelling in iPSC-derived cardiomyocytes from rheumatoid arthritis patients

This study examines bioenergetic and electrophysiological differences in iPSC-derived cardiomyocytes from RA patients based on serotype, finding distinct responses to cytokines and drugs.

Dual effects of nicotinamide on aging-related arrhythmia: protective at low dose, proarrhythmic at high doses

This study investigates the dual effects of nicotinamide on aging-related arrhythmia, showing protective effects at low doses and proarrhythmic effects at high doses in mouse and Drosophila models.

Structural basis for Ca2+-dependent allosteric modulation of cardiac ryanodine receptor by Ryanozole

This study defines the mechanism of Ryanozole's Ca2+-dependent modulation of RyR2 using cryo-EM, mutagenesis, and functional assays, revealing its structural basis for CPVT therapy.

BK Channels Orchestrate Cardiac Homeostasis Through Mitochondrial Uncoupling Proteins

This study identifies BK channels' role in cardiac homeostasis through mitochondrial uncoupling proteins, showing their impact on ventricular function and metabolic pathways.

Regulation of Pacemaker Current in the Sinoatrial Node by Zonula Occludens-1

This study investigates the role of ZO-1 in sinoatrial node automaticity and finds that its loss reduces pacemaker current and impairs atrial conduction, leading to bradyarrhythmia.

Acute sildenafil administration reduces susceptibility to induced atrial fibrillation in sheep

This study shows that acute sildenafil administration reduces atrial fibrillation susceptibility in sheep by prolonging refractory periods and altering electrophysiological properties.

Drug Proarrhythmic Evaluation in a High Throughput Cardiac New Approach Methodology

This paper develops a high-throughput cardiac NAM using hiPSC-derived cardiomyocytes to evaluate drug proarrhythmic potential, showing accurate detection of arrhythmic risk and insights into ion channel effects.