Cancer Cells and Metastasis

Podoplanin-Linked Mesenchymal Shift Synergizes with CCR7 driving Lymphatic Metastasis and Tumor Progression in Breast Cancer

The paper identifies a synergistic role between CCR7 and PDPN-driven mesenchymal shift in promoting lymphatic metastasis and tumor progression in breast cancer.

Identification of a shared persistence program in triple-negative breast cancer across treatments and patients

The paper identifies a shared persistence program in triple-negative breast cancer across treatments and patients, revealing key drivers and mechanisms of drug resistance.

Hyper-responsiveness of cancer stem cells to microenvironmental cues controls metastasis and therapy response through YAP/TAZ/TEAD

This study shows cancer stem cells (CSCs) have distinct population dynamics and are hyper-responsive to microenvironmental cues, which regulate metastasis and therapy response via the YAP/TAZ/TEAD pathway.

Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer

This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.

Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

This study identifies IFN-gamma as a dormancy inducer and IL-17A as a wake-up signal for metastatic cancer cells, showing distinct requirements for induction and awakening from dormancy.

Nonlinear progression during the occult transition establishes cancer lethality

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer.

This study shows pericyte-tumor interactions promote metastatic tumor cell dormancy via PIEZO1-mediated lysophospholipid transfer, enhancing persistence and relapse risk.

Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process

This study develops a side-view observation device to enable non-destructive, real-time in situ monitoring of 3D tumor spheroid formation, migration, and fusion dynamics.

Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

This study identifies COL10A1-associated gene networks in breast and pancreatic cancer that link to EMT, immunosuppression, metastasis, and poor prognosis.

Nanoprotrusion enlargement conducts cytocapsular tube elongation along the path of least resistance for metastasis initiation

This study identifies how nanoprotrusions enlarge along paths of least resistance to form cytocapsular tubes, driving metastasis initiation and branching in human tissues.

Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

ERK plays a conserved dominant role in pancreas cancer cell EMT heterogeneity driven by diverse growth factors and chemotherapies

The paper identifies ERK as a dominant driver of EMT heterogeneity in pancreas cancer cells using mutual information modeling and imaging, showing its role is independent of MEK inhibition and growth factors.

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis

This study shows that acidic tumor environments enhance pancreatic cancer stem cell properties and metastasis in mice.

Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system

This study shows that tumoroids from six cancer types can be maintained long-term in a standardized serum-free medium, preserving their genetic and phenotypic features.

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.

Metastatic cell plasticity is maintained by SOX9 function during mitosis in breast cancer

The paper shows that SOX9 maintains metastatic cell plasticity during mitosis by priming chromatin accessibility for dormancy-related transcriptional programs in breast cancer.

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11).

This study identifies E2F4 as a key regulator of colon cancer resistance to irinotecan by showing its role in drug resistance through shRNA knockdown in PDX models.

Hetero-multicellular stromal cells incorporate into scaffold-free 3D cultures of epithelial cancer cells to drive invasion

This paper develops a method to generate hetero-multicellular 3D cultures of breast cancer cells with stromal cells to study invasion and spatial dynamics.

Chlorpyrifos induces lung metastases and modulation of cancer stem cell markers in triple negative breast cancer model

This study shows Chlorpyrifos promotes breast cancer progression, enhances stemness, and induces lung metastases in a mouse model.

Inhibition of EMT driver PTK6 enhances anti-tumor immune responses against triple-negative breast cancer

This study shows that inhibiting PTK6 in triple-negative breast cancer enhances anti-tumor immune responses by increasing CD8+ T and NK cells and reducing immunosuppressive cells.

MAPK14/p38α Shapes the Molecular Landscape of Endometrial Cancer and promotes Tumorigenic Characteristics

This study identifies MAPK14/p38α as critical for HGEC spheroid growth, shaping its transcriptomic, proteomic, and metabolomic landscapes and promoting tumorigenic properties.

Opposing lineage specifiers induce a pro-tumor hybrid-identity state in lung adenocarcinoma

This study identifies HNF4 as a driver of hybrid-identity states in KRAS-driven lung adenocarcinoma, showing that opposing lineage specifiers promote tumor progression and affect therapy response.

Cell-Cell Fusion in NSCLC Promotes Evolution of Therapeutic Resistance

This study shows that cell-cell fusion in NSCLC leads to increased chemoresistance and tumor aggressiveness by creating hybrid cells with enhanced fitness and genomic heterogeneity.

Adherent-to-suspension transition promotes melanoma metastatic dissemination

This study shows that the adherent-to-suspension transition in melanoma cells enhances metastatic potential by reprogramming anchorage dependency, independent of epithelial-to-mesenchymal-like transition pathways.

Cell competition confers anchorage plasticity of disseminated tumor cells

The paper shows cell competition enables loser cells to gain metastatic potential through anchorage plasticity, mediated by AST factors, and demonstrates this in breast cancer metastasis.

Phenomics demonstrates cytokines additive induction of epithelial to mesenchymal transition

The paper uses single cell phenomics to show that combining cytokines additively enhances EMT in cancer cell lines, regardless of their baseline EMT state.

Morpho-molecular features of Epithelial Mesenchymal Transition associate with clinical outcome in patients with rectal cancer

The paper links morpho-molecular features of epithelial-mesenchymal transition (EMT) in rectal cancer biopsies to clinical outcomes, showing their association with survival after chemoradiotherapy.

Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells

This study shows that oncogenic KRAS mutations in colorectal cancer cells lead to a unique mechanotransduction response to peristalsis, increasing cancer stem cell enrichment and tumorigenicity.

Basal EFNA3 Facilitates Luminal-Driving Mammary Epithelial Migration and Cancer Metastasis by Promoting OXPHOS

The paper identifies EFNA3 as a factor promoting mammary epithelial collective migration and cancer metastasis by enhancing oxidative phosphorylation.