Muscle Physiology and Disorders

Circadian Clock Control of Muscle Stem Cells Through Temporal Coordination of Notch and Wnt Signaling

This study shows the circadian clock coordinates Notch and Wnt signaling in muscle stem cells to regulate regeneration, with functional effects in dystrophic muscle and human myoblasts.

Novel truncating Desmin mutation Arg150Stop disrupts structural integrity and cellular homeostasis by formation of persistent aggregate-like structure

This study investigates a novel truncating Desmin mutation, Arg150Stop, showing it causes persistent aggregate-like structures that disrupt cellular homeostasis and cytoskeletal integrity through a toxic gain-of-function mechanism.

Myosin light chain proteins cooperatively promote sarcomere growth in fast-twitch muscle

This study shows that Mylpf proteins are essential for sarcomere growth in fast-twitch muscle, with their dosage affecting sarcomere formation and myofilament localization.

Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD

This study shows that Irodanoprost, a bone-targeted EP4 agonist, reduces fibrosis and restores muscle regeneration in a rat model of Duchenne muscular dystrophy.

FAP-intrinsic Hedgehog signaling controls intramuscular adipogenesis, fibrosis, and myofiber regeneration

This study shows that FAPs are the primary cells responding to Hedgehog signaling during muscle regeneration, and their signaling competence is critical for preventing adipogenesis, fibrosis, and promoting myofiber repair.

Globin digest and its constituent peptides promote skeletal muscle hypertrophy and enhance physical performance

This study investigates the effects of globin digest and its peptides on skeletal muscle hypertrophy and physical performance in zebrafish, mice, and myoblasts, finding significant improvements in muscle growth and motor function.

Vorinostat (SAHA) alters the skeletal muscle differentiation program

This study examines how SAHA affects skeletal muscle differentiation in C2C12 and L6 cells, showing delayed early differentiation and model-dependent changes in gene and protein expression.

The D4Z4caster DNA methylation signature identifies individuals at epigenetic risk for developing facioscapulohumeral muscular dystrophy (FSHD)

This paper validates DNA methylation signatures for FSHD detection using D4Z4caster software and compares Sanger and NGS methods for improved diagnostic accuracy and accessibility.

Regimen-dependent glucocorticoid effects improve muscle performance without altering CNS physiology in mdx mice

This study compares daily and weekly glucocorticoid dosing in mdx mice, showing weekly vamorolone improves muscle function while minimizing adverse effects on metabolism and the CNS.

Sex-specific effects of fatiguing exercise on skeletal muscle passive mechanics are preserved in aging

This study examines sex-specific effects of fatiguing exercise on skeletal muscle passive mechanics in young and older adults, finding preserved sex differences in modulus reduction in males across ages.

Stress unmasks impaired endocrine coordination of glucose metabolism in dystrophin deficiency

This study shows that stress reveals impaired endocrine coordination of glucose metabolism in dystrophin deficiency, with interventions improving glucose control and muscle function.

EYA1/EYA2 and EYA3/EYA4 act as stage-specific SIX cofactors in embryonic and adult regenerative skeletal myogenesis

This study investigates the role of EYA1/EYA2 and EYA3/EYA4 in skeletal myogenesis, showing that EYA3/EYA4 are critical for adult muscle regeneration while EYA1/EYA2 are essential for embryonic development.

FBXL21 regulates diurnal proteostasis and stress response by targeting DNAJB6 and client proteins

This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.

Mechanical Loading Induces the Radial Growth of Myofibrils and Myofibrillogenesis via an mTORC1-Dependent Mechanism

This study shows that mTORC1 regulates myofibrillogenesis and radial myofibril growth in response to mechanical loading in mice.

Rewiring Fibroblast-Muscle Axis Drives Progressive Pathology in Bethlem Myopathy

This study identifies fibroblasts as key drivers of disease progression in Bethlem myopathy using a zebrafish model and single-nucleus RNA sequencing.

Mechanical Signaling Regulates DNA Methylation to Maintain Muscle Stem Cell Quiescence

This study shows that mechanical signals regulate DNA methylation in muscle stem cells to maintain quiescence by preserving Dnmt3a expression through RhoA signaling.

Plasma Micro-RNA Signatures of Type 1 Ryanodine Receptor Related Myopathies

The paper identifies plasma microRNA signatures associated with RYR1-related myopathies, finding hsa-miR-4454 and hsa-miR-7975 are significantly overexpressed in patients.

Drosophila ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human RYR1 mutations

This study shows that the Drosophila RYR gene is essential for muscle development and function and demonstrates its utility in assessing human RYR1 mutations.

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice

This study shows TAK1 regulates skeletal muscle mass, hypertrophy, and metabolism in both male and female mice by affecting signaling pathways and gene expression.

MyoRep: a novel reporter system to detect early muscle atrophy in vitro and in vivo

The paper introduces MyoRep, a reporter system that detects early muscle atrophy in vitro and in vivo, distinguishing pathological from physiological atrophy.

Identification of a new population of myonuclei during skeletal muscle hypertrophy

The paper identifies a new population of myonuclei during skeletal muscle hypertrophy using snRNA-seq and RNAscope, showing distinct localization and gene expression profiles.

EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne Muscular Dystrophy

The paper identifies EMILIN1 as a TGFβ/SETDB1-regulated secreted biomarker in DMD, showing its role in fibrosis and myogenesis through proteomic analysis of patient-derived myotubes.

(-)-Epicatechin modulates skeletal muscle inflammatory response in a mouse model of Limb-Girdle Muscular Dystrophy 2F

This study investigates the effects of (-)-Epicatechin on transcriptional and immune dysregulation in LGMD2F using bulk RNA-sequencing and immune cell-deconvolution in Sgcd-/- mice.

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

This study compares 3D skeletal muscle spheroids (iSMS) with 2D cultures for modeling Duchenne Muscular Dystrophy, finding improved PAX7 expression and altered Notch signaling in iSMS.

Single-cell transcriptional landscape of muscle-derived stem/progenitor cells reveals hallmarks of aging and rejuvenation

The paper profiles murine muscle-derived stem/progenitor cells across age groups using single-cell transcriptomics and proteomics, revealing a transcriptional continuum of maturation and aging-related changes.

NEUROMUSCULAR ELECTRICAL STIMULATION LIMITS MUSCLE WEAKNESS, ATROPHY, MODULATES SATELLITE CELL FUNCTION AND REDUCES INFLAMMATION IN CANCER CACHEXIA

This study shows that neuromuscular electrical stimulation (NMES) reduces muscle weakness and atrophy, improves muscle stem cell function, and modulates inflammation in a mouse model of cancer cachexia.

Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming

This paper demonstrates that AI-designed receptor modulators can drive efficient human fibroblast-to-muscle transdifferentiation by rewiring extracellular signaling.

C26 and CT26 colorectal cancer models exhibit divergent cachexia phenotypes, intramuscular inflammation, and protein turnover signaling

This study compares C26 and CT26 colorectal cancer models, finding that C26 induces more severe cachexia, inflammation, and muscle protein turnover disruption than CT26.

Aspirin hastens resolution of skeletal muscle inflammation and promotes recovery of muscle strength following acute injury

This study shows that aspirin promotes muscle strength recovery and inflammation resolution after injury, unlike other NSAIDs which impair muscle regeneration.

Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle

This study shows that Fat1 deletion increases fibro-adipogenic differentiation and adipogenic expansion in injured skeletal muscle, while having minimal impact on myogenic repair.