Muscle Physiology and Disorders

MYORG and STRADB as Activity-Dependent Therapeutic Targets for Frailty Prevention: Discovery and Cross-Cohort Validation in Aging Skeletal Muscle

The paper identifies MYORG and STRADB as activity-dependent biomarkers for muscle health and challenges conventional atrogene paradigms by showing activity confounds age-based signatures in skeletal muscle.

Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment

The paper shows that ERK1/2 and EZH2 inhibitors increase utrophin expression in myoblasts from healthy and DMD patients, with sustained effects in patient-derived cells.

Autophagy selectively clears ER in inflammation-induced muscle atrophy

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

Macrophage-derived RNAseT2 stimulates muscle stem cell fusion via SLK/N-WASP/actin bundling

This study identifies RNAseT2 as a macrophage-derived factor that promotes muscle stem cell fusion through SLK/N-WASP/actin bundling in mouse and zebrafish.

The Muscle Tissue Environment Limits Muscle Stem Cells in Aged Mice

This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.

Chondrolectin regulates the sublaminar localization and regenerative function of muscle satellite cells in mice

This study identifies chondrolectin as a regulator of satellite cell localization and regenerative function in mice through single-cell RNA-seq and knockout models.

A VLP-based immunogen that elicits selective anti-Myostatin antibodies, enhances muscle mass and strength, and reduces adiposity

This paper develops a VLP-based immunogen, MS2.87-97, that elicits anti-Myostatin antibodies, increases muscle mass and strength, and reduces adiposity in mice.

Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology

This study creates transgenic mouse models with human DUX4 regulatory elements to explore DUX4 expression patterns and their role in FSHD pathophysiology.

Systemic Delivery of Human Mesangioblasts mediated by a Nanofiber Scaffold restores Dystrophin Expression in Immunodeficient Dystrophic Mice.

This paper describes a method using a nanofiber scaffold to deliver mesangioblasts systemically, restoring dystrophin expression in DMD mice.

AAV-Delivered RNAi Targeting Mutant LDB3 Prevents and Reverses Myofibrillar Myopathy through Mechanosignaling Restoration

This study shows that AAV-delivered RNAi targeting mutant LDB3 can reverse or prevent myofibrillar myopathy by restoring mechanosignaling pathways in mice.

An Intermediate Mesoderm Premyogenic Niche Supports Early Human Myogenic Lineage Progression

This paper identifies an intermediate mesoderm niche that supports early human myogenic lineage progression through BMP7 and laminin signaling, and shows the role of SIX1-EYA3 activity in this process.

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway

This study identifies defective muscle stem cell plasticity in dermatomyositis patients, linked to chronic inflammation and disrupted H3.3 chromatin loading, impairing myogenesis.

LOSS OF PARKIN DISRUPTS NUCLEAR AND MITOCHONDRIAL PROGRAMS REQUIRED FOR MUSCLE REGENERATION

This study shows PARKIN is essential for coordinating mitochondrial and nuclear processes in muscle stem cells during regeneration, with loss of PARKIN causing metabolic and RNA processing defects.

Myofibers drive postnatal myonuclear accretion through Arp2/3-dependent membrane protrusions

This study shows that myofibers use Arp2/3-dependent membrane protrusions to drive myoblast fusion and myonuclear accretion during postnatal muscle growth.

Baculovirus-mediated gene transfer enables functional expression of PIEZO1 ion channel in isolated muscle satellite cells

This study develops a baculovirus-mediated method to express PIEZO1 in muscle satellite cells, restoring their proliferative capacity and enabling functional studies of large proteins.

Laminin-α2 is required for the maintenance of the myotendinous junction in vivo

This study shows that laminin-α2 is essential for maintaining the myotendinous junction structure, and mechanical unloading affects its integrity in a mouse model of LAMA2-related muscular dystrophy.

Synergistic Electroceutical-Glucocorticoid Intervention Mitigates Dexamethasone-Induced Muscle Atrophy in Aging Skeletal Muscle

This study shows electroceutical treatment reduces DEX-induced muscle atrophy in both young and aged skeletal muscle cells and mice, improving muscle fiber size and gene expression.

Exercise induces Skeletal Muscle Methylome and Transcriptome changes, regardless of Age and COPD

This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.

Females are protected from semaglutide-induced muscle loss in ob/ob mice

This study shows that semaglutide causes muscle loss in male ob/ob mice but not in female ob/ob mice, revealing sex-specific effects on skeletal muscle mass and metabolism.

Linear Z-line-like alignment of capping protein in obliquely striated muscle of the nematode C. elegans suggests that dense bodies are not equivalent to Z-lines

The paper shows that in C. elegans obliquely striated muscle, actin barbed ends are aligned in a linear Z-line-like arrangement without anchoring to dense bodies, challenging the traditional view of sarcomere organization.

Injury-Specific Muscle Regeneration: A Computational Blueprint for Cellular and Cytokine Drivers

The paper extends a computational model of skeletal muscle regeneration to simulate and validate injury-specific responses to CTX, FI, and EC injuries, revealing distinct cytokine and cell dynamics across injury types.

Effects of fibroblast growth factor 2 on muscle precursor cells from mouse limb and extraocular muscle

This study examines the effects of FGF2 on muscle precursor cells from mouse limb and extraocular muscles, finding increased proliferation and differentiation but reduced fusion into multinucleated myotubes.

15-PGDH Inhibition Overcomes Muscle Regenerative Deficit Seen With GLP1-Receptor Agonist-Induced Weight Loss

The paper shows that inhibiting 15-PGDH counteracts muscle regeneration deficits caused by GLP-1 receptor agonist-induced weight loss in mice.

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

This study shows repeated disuse atrophy creates a molecular memory in skeletal muscle, leading to transcriptional resilience in young adults but increased susceptibility in aged muscle.

Divergence in skeletal muscle growth by differential spatial hyperplastic patterning in teleost fishes

The paper compares muscle growth dynamics across teleost fish species, identifying spatial hyperplastic patterning and stem cell gene expression as key factors in growth differences.

Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophy

This study generates a rat model of Duchenne muscular dystrophy using CRISPR/Cas9 and evaluates its functional and structural muscle pathologies across different ages.

Hb-EGF directs systemic muscle repair

The paper shows that systemic muscle injury in zebrafish activates Hb-EGF in the epidermis, which is necessary for systemic repair, while local injury does not require Hb-EGF.

Activating FGFR1 restores Integrin-β1--mediated fibronectin sensing in satellite cells of aged mice

This study shows that activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in aged satellite cells, improving their regenerative capacity.

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse

This study identifies myofibril loss as the primary cause of muscle fiber atrophy in aging and disuse, using macroscopic to ultrastructural analyses in humans and mice.