Chemokine receptors and signaling

Engineering potent avian GPR25 agonists using an ostrich CXCL17 gene relic

This study engineers potent avian GPR25 agonists by grafting a fragment from an ostrich CXCL17 gene relic onto other species' CXCL17 proteins, showing enhanced activity at avian GPR25 receptors.

Programming Targeted Immune Cell Migration Using Orthogonal Chemokine-Receptor Pairs

This study engineers orthogonal chemokine-receptor pairs to enable targeted immune cell migration and collective swarming behavior in engineered T cells.

CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seeding

This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.

Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

The paper designs miniproteins that selectively block or bias chemokine receptor signaling by targeting CCL25, demonstrating their ability to suppress CCR9 and modulate ACKR4 responses.

Distinct atypical chemokine receptor 1 determinants underlie bacterial toxins recognition and pore formation

This study identifies distinct determinants of ACKR1 recognition by bacterial toxins, revealing a two-step mechanism involving sulfotyrosine binding and extracellular vestibule interaction.

Chemokine Landscapes of the Tumor Microenvironment

The paper maps chemokine landscapes in solid tumors using spatial transcriptomics, identifying conserved and tumor-specific patterns and revealing perivascular CCR7 dendritic cells as key sources of lymphocyte-attracting chemokines.

Basal Internalization and Subcellular Localization of XCR1

This study investigates XCR1 internalization and localization mechanisms, revealing AP2-dependent constitutive endocytosis and sequence motifs critical for trafficking.

Chemokine and opioid peptide scavenging through constitutive and ligand-induced release of ACKR3-bearing extracellular vesicles

This study shows ACKR3 is released on extracellular vesicles under both basal and ligand-induced conditions, sequestering chemokines and opioid peptides and modulating their signaling.

Chemokine Signaling Shapes Hepatic Lipid Homeostasis through the CXCL12/CXCR4/CXCR7 Axis

This study identifies the CXCL12/CXCR4/CXCR7 axis as a regulator of hepatic lipid homeostasis, showing CXCR7's role in lipid accumulation and suggesting it as a therapeutic target for metabolic liver disease.

IgE-producing cells on the move: CCR2 is a key regulator of IgE+plasma cell migration

This study identifies CCR2 as a key regulator of IgE-producing plasma cell migration by comparing their chemokine receptor profiles and migration behavior to IgG1+ cells.

Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent

This study compares the conformational dynamics of ACKR3 and CXCR4 using MD simulations and BRET assays, revealing that ACKR3's dynamic behavior leads to activation-proneness and G protein-incompetence.

CXCR4 antagonism restores dendritic cell migration and activation in a WHIM syndrome mouse model

This study shows that inhibiting CXCR4GOF restores dendritic cell migration and activation in a WHIM syndrome mouse model, improving skin immunity.

Monocyte Migration Emerges from a Divergent Chemokine Signaling Network

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

Endothelial ACKR1 expression regulates neutrophil infiltration and breast cancer metastatic engraftment in the lung metastatic niche

This study shows that endothelial ACKR1 promotes neutrophil infiltration and breast cancer metastasis in the lung by facilitating tumor cell engraftment.

Molecular basis of promiscuous chemokine-engagement by the Duffy antigen receptor

This study determines the cryo-EM structures of DARC bound to chemokines CCL7 and CXCL8, revealing unique binding mechanisms and the role of tyrosine sulfation and allelic variation in chemokine engagement.

Identification and functional characterization of CXCL17 in cartilaginous fishes reveals an ancient origin of the CXCL17-GPR25 signaling pathway

This study identifies and functionally characterizes CXCL17 in cartilaginous fishes, revealing its ancient origin in the CXCL17-GPR25 signaling pathway.

GPCR kinase 3 phosphorylates atypical chemokine receptor 4 independent of G proteins

This study shows ACKR4 is phosphorylated by GRK3 without needing G protein activation, through a unique receptor motif that recruits the kinase directly.

Osteoblasts Exert a Pro-Tumorigenic Effect on Breast Cancer Spheroids Through CXCL5/CXCR2 Signaling In 2D And 3D Bone Mimetic Cultures

This study shows osteoblasts promote breast cancer growth via CXCL5/CXCR2 signaling in 2D and 3D bone-like cultures, with osteoblasts having a stronger effect in 3D models.

Macrophage chemotaxis steered by complex self-generated gradients of complement C5a

This study shows mouse and human macrophages use self-generated C5a gradients for chemotaxis, with distinct degradation mechanisms and optimal concentrations.

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages.

The paper shows that chemokine receptors in macrophages are non-redundant and change with differentiation and inflammatory stimuli.

The CXCL10/CXCR3 axis is essential for sustaining immunological dormancy in breast cancer

This study identifies the CXCL10/CXCR3 axis as critical for maintaining immunological dormancy in breast cancer and shows its potential as a therapeutic target and prognostic marker in TNBC.

The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS

The paper demonstrates a synthetic dual-moiety strategy to design CXCR4 agonist peptides that mimic SDF-1, showing therapeutic benefit in a mouse model of ALS through neuroprotection.

Crosslinked CXCR4 Signals Decreased Motility and Increased Adhesion of T Cells

This study shows that crosslinked CXCR4 on T cells reduces their motility and increases adhesion through a non-Gi-dependent pathway involving PTK2B and integrin β4.

Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells

This study identifies a CXCL12/CXCR4/BMI1 signaling axis that promotes metastasis in PDAC via tumor-stroma crosstalk and shows that JM#21, a CXCR4 inhibitor, suppresses miCSCs and enhances chemotherapy efficacy.

Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

NMI induces chemokine release and recruits neutrophils through the activation of NF-kappaB pathway

This study shows NMI promotes neutrophil recruitment by activating the NF-kappaB pathway and inducing chemokine release in murine models.

ACKR5/GPR182 is a scavenger receptor for the atypical chemokine CXCL17, GPR15L and various endogenous peptides

This study identifies GPR182/ACKR5 as a scavenger receptor for CXCL17, GPR15L, and endogenous peptides, revealing distinct binding modes and expanding its ligand repertoire beyond classical chemokines.

Allosteric inhibition of CXCR1 and CXCR2 abrogates Th2/Th17-associated Allergic Lung Inflammation in Mice

This study shows that inhibiting CXCR1 and CXCR2 reduces Th2/Th17-driven allergic lung inflammation in mice by blocking cell recruitment and cytokine expression.

Disruption of maternal ACKR3 has profound effects on embryos and offspring.

This study shows that blocking maternal ACKR3 increases CXCL12 in embryos, leading to developmental issues and impaired immune responses in offspring.

In silico analysis of single nucleotide polymorphisms (SNPs) in human C-C chemokine receptor type five (CCR5) gene

The paper analyzes SNPs in the CCR5 gene to assess their impact on protein structure and function, identifying deleterious variants associated with HIV resistance.