H. Jiang

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Targeting GDF15 as a potential therapy for low back pain originating from endplate

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex restrains excessive mitophagy to prevent mitochondrial disease

This study identifies SCF-FBXL4 as a mitochondrial ubiquitin E3 ligase that suppresses mitophagy, and shows that its loss causes mitochondrial disease.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

JGI Plant Gene Atlas: An updateable transcriptome resource to improve structural annotations and functional gene descriptions across the plant kingdom

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

Maternal Hepatocytes Heterogeneously and Dynamically Exhibit Developmental Phenotypes Partially via YAP1 during Pregnancy

This study shows maternal hepatocytes acquire developmental phenotypes during pregnancy, partially via YAP1, and maintain metabolic zonation independently of the Hippo/YAP1 pathway.

Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cord using micropatterned human pluripotent stem cells

This study demonstrates that micropatterned human pluripotent stem cells self-organize into distinct midbrain and hindbrain/spinal cord regions, revealing a novel regulatory mechanism for AP patterning.

Individual tree-based vs pixel-based approaches to mapping forest functional traits and diversity by remote sensing

This study compares tree-based and pixel-based remote sensing approaches for mapping forest functional traits and diversity, finding that tree-based methods better capture trait variation at high resolution.

The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2

The paper presents the cryo-EM structure of the chicken CENP-A nucleosome complexed with ggKNL2, revealing how ggKNL2 recognizes CENP-A and facilitates its deposition.

Substrate adhesion determines migration during mesenchymal cell condensation in chondrogenesis

This study shows that substrate adhesion controls mesenchymal cell migration and condensation during chondrogenesis by modulating migration modes and cell-cell interactions.

Multiple omic investigations of freeze tolerance adaptation in the aquatic ectothermic vertebrate, the Amur sleeper

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

Engineering and characterization of a long half-life relaxin receptor RXFP1 agonist

This study engineers a relaxin-2 variant with a longer serum half-life by fusing it with an antibody Fc fragment, maintaining RXFP1 agonist activity in vitro and in vivo.

PanGu Drug Model: Learn a Molecule Like a Human

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

Intracranial Electric Field Recording During Multichannel Transcranial Electrical Stimulation

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

Ca2+ Mediates HIF-dependent Upregulation of Aquaporin 1 in Pulmonary Arterial Smooth Muscle Cells

This study shows that in pulmonary arterial smooth muscle cells, HIF upregulates AQP1 protein through Ca2+ elevation rather than direct transcriptional regulation.

The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels

The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.

Structural basis of main proteases of coronavirus bound to drug candidate PF-07321332

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.