H. Jiang

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

Activin B Promotes the Initiation and Progression of Liver Fibrosis

This study shows activin B promotes liver fibrosis initiation and progression by acting on hepatocytes and hepatic stellate cells, and its neutralization prevents and regresses fibrosis in mice.

Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

This study shows that Ascl1 activation in maternal liver during pregnancy supports healthy pregnancy outcomes by coordinating maternal organ adaptations and placental growth.

The Lack of Nrf2 Causes Hepatocyte Dedifferentiation and Reduced Albumin Production in an Experimental Extrahepatic Cholestasis Model

This study shows that Nrf2 deficiency leads to hepatocyte dedifferentiation and reduced albumin production in a cholestasis model.

Simulations of fluorescence imaging in the oral cavity

The paper simulates fluorescence imaging in the oral cavity using a 3D model and compares simulated data with real camera data to quantify porphyrin fluorescence relative to other fluorophores.

Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

This study shows that stromal collagen structures in pancreatic ductal adenocarcinoma promote early dissemination from pre-malignant lesions and ongoing invasion, suggesting FAK inhibition or stroma normalization could limit metastasis.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform of cancer screening for early detection of cancer

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

Oxidized LDL but not angiotensin II induces the interaction between LOX-1 and AT1 receptors

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

Rapid evolution of bacterial mutualism in the plant rhizosphere

This study shows that a plant-antagonistic bacterium can evolve into a mutualist in the Arabidopsis rhizosphere within six months through genetic changes enhancing competitiveness and plant signaling activation.

Experimental evolution-driven identification of Arabidopsis rhizosphere competence genes in Pseudomonas protegens

This study uses experimental evolution to identify 35 mutations in 28 genes that enhance Pseudomonas protegens' ability to colonize the Arabidopsis thaliana rhizosphere.

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

Intracellular localisation of Mycobacterium tuberculosis affects antibiotic efficacy

This study investigates how the intracellular localization of Mycobacterium tuberculosis affects the efficacy of the antibiotic pyrazinamide (PZA) using multimodal microscopy techniques.

Genome-wide screen of genomic imprinting in endosperm and population-level analysis reveal allelic variation for imprinting in flax

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

Human fecal microbiota is associated with colorectal cancer

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

A versatile resource of 1500 diverse wild and cultivated soybean genomes for post-genomics research

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma Using Autophagy Inhibition, MEK blockade and CD40 Agonism

This study shows that combining MEK inhibition, autophagy inhibition, and CD40 agonism activates the Type I Interferon/STING pathway in PDA tumors, reprograms TAMs, and enhances anti-tumor immunity in a mouse model.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

A comparison of Remdesivir versus Au22Glutathione18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

Open Science Saves Lives: Lessons from the COVID-19 Pandemic

The paper discusses the adoption and misuse of Open Science principles during the COVID-19 pandemic and advocates for their wider implementation to ensure rigorous and transparent research.

Correlative Light Electron Ion Microscopy reveal in vivo localisation of bedaquiline in Mycobacterium tuberculosis infected lungs

The paper uses CLEIMiT to show bedaquiline accumulates in specific cell types in M. tuberculosis infected lungs.

SvFUL2, an A-class MADS-box transcription factor, is necessary for inflorescence determinacy in model panicoid cereal, Setaria viridis

This study identifies SvFUL2, an A-class MADS-box transcription factor, as essential for inflorescence determinacy in Setaria viridis, showing that its disruption leads to indeterminate inflorescence and altered meristem behavior.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.