S. Yu

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

LPS-TLR4 pathway exaggerates alcohol-induced acute-on-chronic liver failure via provoking NETs formation

This study shows that the LPS-TLR4 pathway promotes NETs formation in AACLF, exacerbating liver injury through mechanisms involving gut-derived LPS and neutrophil activity.

Naive arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen

This study identifies a defect in anergy and a biased TCR repertoire in naive arthritogenic SKG CD4 T cells, driven by endogenous viral superantigens, leading to autoimmune arthritis.

Vapor cannabis exposure generationally affects male reproductive functions in mice

This study shows that cannabis vapor exposure in adult male mice reduces sperm count and motility in F0 and F1 generations but not F2, and disrupts spermatogenesis and DNA methylation in F1 testes.

Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system

This paper introduces an integrated system for automated multi-functional imaging and analysis to study YAP mechanosensitivity in human cells.

Adjuvant and immunomodulatory potential of Natural Killer T (NKT) activation by NKTT320

This study evaluates the adjuvant and immunomodulatory effects of NKTT320, a humanized monoclonal antibody that activates iNKT cells, showing enhanced immune responses and inflammation resolution.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

Scalable, Micro-Neutralization Assay for Qualitative Assessment of SARS-CoV-2 (COVID 19) Virus-Neutralizing Antibodies in Human Clinical Samples

The paper describes a modified fluorescence reduction neutralization assay for quantitatively assessing SARS-CoV-2 neutralizing antibodies in clinical samples, demonstrating its efficiency and accuracy.

Detailed characterization of the UMAMITs provides insight into their evolution, functional properties as amino acid transporters and role in the plant

The paper characterizes 44 Arabidopsis UMAMITs, showing their localization and function as amino acid exporters, providing insights into their evolutionary role and transport properties.

Priming Is Dispensable For NLRP3 Inflammasome Activation In Human Monocytes

This study shows that the priming step is not required for NLRP3 inflammasome activation in human monocytes, as nigericin and IL-37 can trigger caspase-1 activation and cytokine release without prior priming.

Induction of GLUTAMINE DUMPER1 reveals a link between amino acid export, abscisic acid, and immune responses

Genetically induced disturbance of amino acid homeostasis sequentially triggers responses to abiotic stresses and plant defenses to pathogens in Arabidopsis through undefined sensing mechanisms.

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to construct pluripotency gene regulatory network

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

This study shows that restoring glucocerebrosidase in muscle tissue reduces protein aggregation in both muscle and brain in a Drosophila model of Parkinson's disease by regulating extracellular vesicle content.

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

An Evaluation of the Efficacy of Preclinical Models of Lung Cancer Drugs

This study evaluates preclinical models of lung cancer drugs and finds no significant linear trend between preclinical success and drug approval.

Biomechanical Analysis of Angular Motion in Association with Bilateral Semicircular Canal Function

This study develops a finite element model of bilateral human semicircular canals to analyze cupular expansion and deflection during head rotation, showing their mechanical roles in vestibular function.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.

IL-1RA controls the development of esophageal cancer by inhibition of VEGF via PI3K/NF-κB signaling pathway

This study shows IL-1RA inhibits esophageal cancer progression by suppressing VEGF through the PI3K/NF-κB pathway, suggesting it as a potential therapeutic target.

EPS8 facilitates uncoating of influenza A virus

This study identifies EPS8 as a host factor that facilitates influenza A virus uncoating by delaying nuclear import of ribonucleoprotein complexes.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

Characterization of pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae

This study characterizes the pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae, showing their surface localization and binding to plasminogen and fibronectin, which contribute to adhesion.

Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry

The paper shows that tibrovirus glycoproteins can enter human, bat, and nonhuman primate cells, but replication resistance varies among cell types.

Effects of Biogas Slurry on Fruit Economic Traits and Soil Nutrient of Camellia oleifera Abel

This study examines how biogas slurry affects soil nutrients and economic traits of Camellia oleifera fruits, finding that higher application rates improve soil fertility and fruit yield.

Identification, Genotyping, and Pathogenicity of Trichosporon spp. Isolated from Giant Pandas

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

Molecular mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct proteoforms within the coupled positive and negative feedback circuits

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

Catalysis of cataract-associated human γD crystallin aggregation via dynamic disulfide exchange

The paper shows wild-type human γD crystallin catalyzes aggregation of its W42Q variant through disulfide bond transfer, revealing a redox mechanism relevant to protein aggregation in oxidizing environments.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.