MicroRNA in disease regulation

Identification of a Novel miRNA Expression Signature for Lung Adenocarcinoma Using Systematic Machine Learning Optimization

This paper identifies a miRNA signature for lung adenocarcinoma using machine learning on TCGA data, achieving high accuracy and stability.

A Novel miR-4745-KLC2 Axis Regulates Cancer Stem Cell Traits in Colorectal Cancer

This study identifies miR-4745 as a regulator of cancer stem cell traits in colorectal cancer, showing it inhibits CSC self-renewal and chemoresistance by targeting KLC2.

Yin Yang Interactomes Drive the Metabolic Dysfunction-Associated Liver Disease Continuum to Hepatocellular Carcinoma

The paper identifies tumor-suppressive miRs and their oncogenic gene targets that may drive progression from MASLD to HCC.

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation

This paper identifies how a human AGO-miRNA-trigger complex binds ZSWIM8 for CUL3-mediated polyubiquitylation, leading to target-directed miRNA degradation.

An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis, independent of tissue-specific Microprocessor condensates

MIRit: an integrative R framework for the identification of impaired miRNA-mRNA regulatory networks in complex diseases

MIRit identifies impaired miRNA-mRNA regulatory networks in diseases by integrating multi-omic data, revealing dysregulated pathways in thyroid cancer and Alzheimer's disease.

In Vivo AGO-APP For Cell-Type- and Compartment-Specific miRNA Profiling in the Mouse Brain

The paper introduces a method to profile miRNA expression in specific cell types and compartments in the mouse brain using transgenic mice and validates its effectiveness through bioinformatic analysis.

MicroRNA-mRNA Gene Regulatory Circuitry Orchestrates the Epigenetic and Transcriptional Reprogramming from Pluripotency to Murine Mammary Epithelial stem-like-Cells lactogenic differentiation

The paper identifies miRNA-mRNA regulatory networks during lactogenic differentiation of murine mammary epithelial cells, revealing key signaling pathways and epigenetic regulators involved in the transition from pluripotency to lactation.

MicroRNA-383-5p alleviates hemorrhagic transformation and improves outcomes after endovascular recanalization for acute ischemic stroke

This study shows that miR-383-5p reduces hemorrhagic transformation and improves outcomes after reperfusion in acute ischemic stroke by targeting NOX4 and reducing oxidative stress.

An AI-Guided Framework Reveals Conserved Features Governing microRNA Strand Selection

This paper develops an AI-driven framework to predict and explain miRNA strand selection across species, revealing conserved rules governing this process.

Derepression of a single microRNA target causes female infertility in mice

This study shows that derepression of Zeb1, a target of miR-200a/b, causes infertility in mice by disrupting pituitary hormone production and gene expression.

Kinetic measurements of the fluorescent protein synthesis facilitate determination of the miRNA activity.

The paper develops miRNA sensors using fluorescent protein synthesis to measure miRNA activity, showing faster response times compared to degradation-based methods.

DICER1 syndrome mutations lead to a gain of 3p-miRNA function, HERVH activity and increased metastatic potential

This study shows that DICER1 mutations lead to increased 3p-miRNA activity, HERVH activation, and metastatic potential without causing genomic instability.

miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

Mapping the microRNA-mediated crosstalk between insulin resistance and Alzheimers disease : a computational genomic insight

This study identifies microRNAs that regulate genes involved in both insulin resistance and Alzheimer's disease, suggesting potential molecular links between the two conditions.

Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning Approach

The paper uses multi-omics data and machine learning to identify miRNA-DDR gene interactions in PAAD, revealing miRNAs correlated with patient outcomes and potential targets for precision oncology.

MicroRNA profiling identifies novel regulators of stem cell function in the adult Drosophila intestine.

The paper identifies novel microRNA regulators of stem cell function in Drosophila adult intestine through profiling and functional validation of miR-31a and miR-34.

Promoter DNA Methylation Epigenetically Regulates the Tumor-Suppressor Function of the miR-379/656 (C14MC) Cluster in Hepatocellular Carcinoma

This study shows that the miR-379/656 cluster is a tumor suppressor in HCC regulated by promoter DNA methylation, with potential for early diagnosis and prognosis.

Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons

The paper compares miRNA profiles across HT22, N2A, SH-SY5Y cell lines and primary mouse hippocampal neurons to assess their similarity to primary neurons.

MicroRNAs are differentially altered by ethanol and caffeine consumption in the rat prostate

This study examines how ethanol and caffeine affect microRNA expression in rat prostate tissue, finding that both substances modulate miRNAs related to inflammation and adenosinergic pathways, with caffeine potentially offering protective effects.

Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets

This study identifies synergistic microRNAs that suppress glioblastoma progression by targeting key pathways and genes associated with tumor growth and poor prognosis.

The Small Non-coding RNA miR-16-1-3p Hampers Cancer Stem Cell Self-renewal and Invasiveness, Boosting Chemosensitivity by Adjusting TGF-β1 Signaling via MDM2/p53 Axis in Human Osteosarcoma.

This paper shows miR-16-1-3p reduces cancer stem cell self-renewal and invasiveness in osteosarcoma by modulating TGF-β1 signaling through the MDM2/p53 axis, enhancing chemosensitivity to cisplatin.

Sulindac Sulfide Suppresses Oncogenic Transformation Through let-7b-Mediated Repression of K-Ras Signaling

This study shows sulindac sulfide inhibits cell transformation by upregulating let-7b, which suppresses K-Ras signaling through ERK inhibition, revealing a novel regulatory axis in cancer chemoprevention.

Leveraging Disease Association Degree for High-Accuracy MicroRNA Target Prediction

This paper predicts functional miRNA-target interactions using disease association features, achieving high accuracy without relying on experimental data.

miR-6850 Drives Phenotypic Changes and Signaling in High Grade Serous Ovarian Cancer

This study identifies miR-6850 as a tumor-suppressive miRNA in high-grade serous ovarian cancer, showing its anti-oncogenic effects and potential as a biomarker and therapeutic target.

Human Dicer1 hotspot mutation induces both loss and gain of miRNA function

This study investigates the effects of a Dicer1 mutation on miRNA function, showing both loss and gain of miRNA activity through strand switching.

miRScore: a rapid and precise microRNA validation tool

miRScore validates miRNA annotations using sRNA-seq data by combining structural and expression analyses to improve accuracy and reliability.

A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

A microRNA CRISPR screen reveals miR-483-3p as an apoptotic regulator in prostate cancer

The paper uses a CRISPR-based screen to identify miR-483-3p as a key apoptotic regulator in prostate cancer, showing its role in cell survival and potential as a therapeutic target.

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice

This study shows that reducing miR-21 levels worsens liver disease and cancer in high-fat-diet-fed mice, while miR-21 mimics improve disease outcomes.