Microtubule and mitosis dynamics

Microtubule lattice conformation and integrity regulate α-tubulin acetylation

This study shows that microtubule lattice conformation and integrity regulate TAT1-mediated α-tubulin acetylation, with expanded lattices enhancing acetylation and compacted lattices reducing it.

Telomeric heterochromatin acts in trans to promote meiotic centromere assembly via Aurora B kinase recruitment

The paper shows telomeric heterochromatin promotes meiotic centromere assembly by recruiting Aurora B kinase through Swi6HP1 and Haspin-dependent phosphorylation of centromere proteins.

AKIP1 is an inner scaffold component required for centriole integrity

The paper identifies AKIP1 as a novel inner scaffold component essential for centriole integrity through functional genomic analysis and imaging.

Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling

The paper identifies a non-autonomous role for somatic cells in maintaining germline incomplete cytokinesis through FGF signaling in Drosophila.

Structural Basis of betaKNL2 Centromeric Targeting Mechanism and Its Role in Plant-Specific Kinetochore Assembly

This study identifies the structural basis of βKNL2 centromeric targeting and its role in plant-specific kinetochore assembly, showing its dependence on the SANTA domain and interactions with centromeric DNA and KNL2.

Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

This study shows that TORC1 modulates cohesin functions in chromosome segregation and gene expression, linking environmental changes to chromosome stability.

Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis

The paper shows importin-β1 senses Ran-GTP gradients to position the contractile ring during cytokinesis, with effects dependent on cell ploidy.

Protection and deprotection of the Rec8 cohesin complex during meiosis

The paper investigates the protection of Rec8 cohesin during meiosis II by analyzing the roles of Sgo1 and Moa1 in fission yeast.

Single kinetochores execute an ordered series of molecular events as the Spindle Assembly Checkpoint is silenced

The paper maps the ordered molecular events of SAC silencing at single kinetochores using MAD2 levels, revealing sequential unbinding, structural reorganization, and stabilization processes.

Molecular mechanism for the functional divergence between cohesin paralogs during meiosis

This study identifies the molecular mechanisms that distinguish meiotic cohesin paralogs from their mitotic counterparts in Schizosaccharomyces pombe, showing why mitotic proteins cannot fulfill meiotic functions.

CAMSAP2 condensates drive a γ-TuRC-independent pathway for non-centrosomal microtubule nucleation

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

A centrin-Sfi1 myoneme fishnet powers ultrafast calcium-triggered contraction in the giant ciliate Spirostomum ambiguum

This paper investigates ultrafast contraction in Spirostomum using myonemes, showing centrin-Sfi1 structures drive calcium-triggered contraction without actomyosin or ATP.

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite gamma-tubulin complex docking sites

The paper shows phosphorylation remodels centrosome matrix proteins to create docking sites for gamma-tubulin complexes, enabling microtubule nucleation during mitosis.

MCAK/Kif2C centromeric activity level tunes K-fiber turnover through distinct pathways.

This paper shows that both excess and insufficient MCAK/Kif2C levels disrupt k-fiber turnover and increase chromosome segregation errors by altering tubulin ratios and MT interactions at kinetochores.

Functional Interaction of SKA and NDC80 Complexes at Kinetochores Promoting Anaphase Onset in Mitosis

This study identifies a critical segment in SKA3's C-terminus that mediates interaction between SKA and NDC80 complexes, essential for metaphase-to-anaphase transition in mitosis.

A Moonlighting Function of Kinetochore Complex Proteins in Golgi Assembly of Neural Stem Cells

This study shows that kinetochore proteins in Drosophila and human cells support Golgi assembly and microtubule dynamics in quiescent neural stem cells.

Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast

This study shows Scm3 interacts with N-terminal Cse4 to stabilize kinetochore assembly in budding yeast and suggests implications for human disease.

Temporal changes in surface tension guide the accurate asymmetric division of Arabidopsis zygotes

The paper shows that temporal changes in surface tension at the growing tip of Arabidopsis zygotes maintain cortical microtubule bands, which guide the formation of the preprophase band and ensure asymmetric cell division.

Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo.

The paper shows elevated temperature disrupts nuclear divisions in Drosophila embryos, leading to developmental defects and lethality, with F-actin-microtubule interactions being a key vulnerability.

The SKA complex is a mitotic vulnerability of chromosomally unstable cancers

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

Energetic gradients emerge in developing motor-microtubule structures

The paper measures ATP gradients in motor-microtubule assemblies and shows they are sustained by energy consumption, with implications for cytoskeletal organization.

Taxol exploits molecular switches within tubulin to stabilize microtubules.

This study identifies structural switches in tubulin that Taxol exploits to stabilize microtubules by reverting them to a pre-hydrolysis state.

KATANIN is required for the formation of complete preprophase bands and subsequent division positioning of subsidiary mother cells in maize

This study shows that KATANIN p60 is essential for forming complete preprophase bands in maize, which is necessary for proper division positioning of subsidiary mother cells.

The P3018S disease variant reveals how dynein's trailing motor sets ensemble velocity.

The paper investigates how the P3018S mutation in dynein affects its function, revealing that the trailing motor in multi-dynein assemblies dictates ensemble velocity.

A Rab-Kinesin12-Fused kinase module couples vesicle delivery and phragmoplast remodelling during cytokinesis in Arabidopsis

Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

The Spectraplakin Short Stop (Shot) Organizes an Acentrosomal Microtubule Network in Early Oogenesis, Essential for Nuclear Positioning.

This study identifies a non-centrosomal microtubule-organizing center (ncMTOC) in Drosophila oocytes that is essential for nuclear positioning during early oogenesis.

Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events

This study shows that Greatwall kinase coordinates meiotic divisions by regulating PP2A-B55, which controls APC/C and Mos/MAPK pathways in Xenopus oocytes.

A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis

This study identifies Plasmodium NEK4 as a key regulator that couples meiotic initiation with zygote morphogenesis in malaria parasites.

Profiling cell proliferation after whole-genome duplication in human cells

The paper uses live-imaging to study proliferation dynamics of post-WGD HCT116 cell lineages, finding that multipolar chromosome segregation limits proliferative capacity.