Neurogenesis and neuroplasticity mechanisms

PRDM16 co-operates with LHX2 to shape the human brain

The paper investigates PRDM16's role in human brain development by analyzing a patient mutation and cortical organoids, revealing its collaboration with LHX2 in gene regulation.

Patterning ganglionic eminences in developing human brain organoids using morphogen gradient inducing device

This paper introduces a device to generate morphogen gradients for creating patterned brain organoids, revealing distinct cell types and long-term stability.

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis.

The paper identifies COX2-derived prostaglandin D2 as a promoter of spinal cord neurogenesis through in vivo drug screening and single-cell RNAseq analysis in zebrafish.

Expression of the transcription factor Isl1 in dopaminergic neurons of the mouse forebrain

This study investigates the expression pattern of the transcription factor Isl1 in dopaminergic neurons of the developing mouse forebrain, identifying its role as a molecular marker.

STAT3 regulates the generation of astroglia inhuman brain organoids with high mTORC1 activity

The paper shows that STAT3, downstream of mTORC1, regulates astroglia generation in human brain organoids, but mTORC1 is not required for cytokine-induced STAT3 activation.

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis

This study shows that an anti-obesity neuropeptide analogue promotes adult neurogenesis and rescues neuronal survival in diet-induced obesity.

Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

This study shows that adult hippocampal neural stem cells (aNSCs) form in the early postnatal dentate gyrus and require cyclin D2 for their development.

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

Dynamics of Adult Axin2 Cell Lineage Integration in Granule Neurons of the Dentate Gyrus

The paper traces Axin2-positive cell lineage in adult hippocampal neurons, finding that Axin2 is expressed at multiple stages of differentiation and that integration of adult-born neurons can take longer than previously thought.

Norepinephrine regulates Ca2+ signals and fate of oligodendrocyte progenitor cells in the cortex

The paper investigates how norepinephrine modulates Ca2+ signals and fate decisions in oligodendrocyte progenitor cells (OPCs) in the cortex through behavioral and genetic approaches.

LSD1/KDM1A is essential for neural stem cell differentiation in mice

This study shows that LSD1/KDM1A is essential for neural stem cell differentiation in mice, as its deletion causes perinatal lethality and brain defects, but motor neurons can still be generated.

Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming

This study shows that transient Yamanaka factor expression during development expands the neocortex and improves cognitive function in mice, while intermittent expression in adult neurons protects against Alzheimer's disease features.

A primary culture method for the easy, efficient and effective acquisition of oligodendrocyte lineage cells

The paper introduces a new method for efficiently culturing oligodendrocyte lineage cells, improving yield and reducing time for OPC maturation into oligodendrocytes.

epDevAtlas: Mapping GABAergic cells and microglia in postnatal mouse brains

The paper creates high-resolution 3D atlases of postnatal mouse brains and maps changes in GABAergic cells and microglia across development.

The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice

This study investigates the effects of the 5:2 diet on adult hippocampal neurogenesis and spatial memory in mice, finding no significant impact on neurogenesis or memory performance.

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

This study investigates the effects of intermittent fasting on adult neural stem cells and neurogenesis in mice, finding no significant impact on NSC activation, maintenance, or neurogenesis.

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration

This study shows FEZ1 is essential for human brain development by regulating neuronal progenitor subpopulations and migration, with its deletion causing abnormalities in cortical layer formation.

Assembly of neuron- and radial glial cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

The paper identifies a ternary extracellular matrix complex in the subplate/intermediate zone that supports radial migration of cortical neurons by promoting the multipolar-to-bipolar transition.

Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

This study shows that Dyrk1a regulates interneuron migration via actomyosin dynamics, leading to cortical GABAergic system defects and phenotypes seen in DYRK1A-haploinsufficiency syndrome.

Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons

The paper shows Neurog1 and Olig2 integrate patterning and neurogenesis signals to specify A11-type dopaminergic neurons in zebrafish.

Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex

The paper uses somatic mutations to analyze lineage divergence in human cortical regions, finding late divergence of neuronal cell types and regional inhomogeneities in progenitor proliferation.

Reprogramming early cortical astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site deficient Ascl1

This study reprograms early cortical astroglia into neurons with parvalbumin-positive interneuron features using a modified Ascl1 protein.

Transcriptional Control of Neocortical Size and Microcephaly

This study identifies two transcription factors that regulate neocortical size by controlling progenitor cell behavior and gene expression, with implications for microcephaly.

Hindbrain rhombomere centers harbor a heterogenous population of dividing progenitors which rely on Notch-signaling

The paper identifies heterogeneous dividing progenitors in hindbrain rhombomere centers that rely on Notch3-signaling and exhibit distinct proliferative and neurogenic properties.

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortex

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.

Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

The paper shows asymmetric inheritance of centrosomes in human neural progenitor cells, maintaining self-renewal and proper neurogenesis.

A spatial-temporal map of glutamatergic neurogenesis in embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity

This study maps the spatial-temporal development of glutamatergic neurons in embryonic cerebellar nuclei, revealing significant cellular heterogeneity and distinct subpopulations.

Slitrk/LAR-RPTP and disease-associated variants control neuronal migration in the developing mouse cortex independently of synaptic organizer activity

The paper investigates the role of Slitrk and LAR-RPTP proteins in neuronal migration during mouse cortex development, showing they influence migration independently of synaptic organizer activity.

Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging

This study shows that Shh from mossy cells supports NSC pool maintenance after seizures and in aging by promoting neurogenesis and NSC self-renewal.

Control of timing and directionality during neurodifferentiation of human induced Pluripotent Stem Cells (iPSC) via miRNA-mediated feedback and feedforward loops.

The paper identifies a gene regulatory network involving miRNAs that control neuronal differentiation by blocking REST through feedforward and feedback loops, with implications for neurodevelopmental disorders.