Platelet Disorders and Treatments

An imaging flow cytometry method to study platelet-monocyte aggregates using Long COVID as a model

This study uses imaging flow cytometry to quantify platelet-monocyte aggregates in Long COVID patients and healthy controls, finding significantly elevated levels and altered attachment patterns in patients.

Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization

The paper identifies OR2L13 agonists that reduce platelet reactivity and thrombosis by depolymerizing the actin cytoskeleton through HSP27 phosphorylation.

A Novel VWF Knockout Endothelial Cell Model to Study Von Willebrand Factor Biology and Von Willebrand Disease Mechanisms

The paper introduces a VWF-knockout endothelial cell model to study VWF variants and their impact on von Willebrand disease, showing it can distinguish pathogenic from non-pathogenic variants.

Denatured Albumin Gains a Function of Regulating Platelet Activity

This study shows denatured serum albumin can regulate platelet activity by binding to integrin IIbβ3, similar to fibrinogen, under conditions like alcohol intake or oxidative stress.

Staying on track: collagen fibers orientation strongly affects thrombi formation at high shear

This study shows that type III collagen fibers aligned parallel to flow support stable platelet adhesion at high shear rates, promoting thrombus formation.

Plasmin-mediated cleavage of GPIbα contributes to breakdown of platelet-von Willebrand factor complexes

This study shows plasmin cleaves GPIbα, disrupting platelet-VWF complexes, but not VWF itself, and suggests GPIb shedding may be plasmin-mediated in TTP.

The Kifc3 Motor Protein Controls Centrosomal Factor Cep192 in Ontogenic Coordination of Megakaryocyte Development

This study identifies Kifc3 as a regulator of megakaryocyte development by controlling Cep192, enhancing morphogenesis and thrombopoiesis in neonatal cells.

The alarmin Interleukin-33 modulates platelet proteome, function and biogenesis

This study investigates how IL-33 affects platelet proteome, function, and production, revealing its role in inflammation and thrombopoiesis.

RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response

This study shows RAP1 regulates platelet PtdSer exposure and procoagulant activity through RHOA/integrin-dependent and -independent mechanisms.

Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations

This study investigates how specific MYH9 mutations affect NM2-A aggregation and intracellular dynamics, revealing differences in their molecular impact on cellular function and disease severity.

Megakaryocyte activation and mobilization from the bone marrow in response to trauma and hemorrhagic shock in mice

This study shows trauma and hemorrhagic shock rapidly alter megakaryocyte activity and mobilization in mice within one hour.

Platelet Molecular Maturation Links Platelet Aging and the Platelet Storage Lesion

This paper identifies a conserved molecular maturation program in platelets that links aging and storage lesions, showing cold storage preserves transcript stability and hemostatic function.

ATP11A and ATP11C are plasma membrane phosphatidylserine flippases in in vitro human megakaryocytes.

This study identifies ATP11A and ATP11C as plasma membrane phosphatidylserine flippases in human megakaryocytes using CRISPR-Cas9 knockout experiments.

Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: in silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain

The paper uses computational models to show how R1205 variants in von Willebrand factor alter interactions with LRP1 and GPIb, explaining disease mechanisms and offering therapeutic insights.

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype

This study shows that platelet depletion in schistosomiasis leads to severe bleeding and reduced survival, while platelets do not directly drive macrophage activation in type 2 inflammation.

Paradoxic enhancement of mitochondrial capacity in aging-specific megakaryopoiesis from hematopoietic stem cells

This study shows that aging-specific megakaryocyte progenitors have increased mitochondrial capacity, contrasting with aged hematopoietic stem cells, and that enhancing mitochondrial activity affects platelet production differently in young and old mice.

Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice

This study shows that deleting Shp1 and Shp2 in mice impairs megakaryopoiesis and thrombopoiesis, leading to macrothrombocytopenia and reduced platelet function.

Platelet and releasate lipidomics identify novel platelet activating mechanisms and ether-linked lysophosphatidylcholine and phosphatidylethanolamine 38:7 as predictors for platelet reactivity

This study identifies novel platelet activating mechanisms and specific lipids predicting platelet reactivity through lipidomics analysis of platelets and releasate.

A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging

The paper identifies a rare HSC-derived megakaryocyte progenitor that accumulates with age, contributing to exaggerated thrombopoiesis and age-related platelet-mediated morbidities.

P2Y12-P-Selectin Mediated Platelet Activation Drives Dengue-Associated Thrombocytopenia

This study shows DENV causes thrombocytopenia through impaired megakaryopoiesis and P-selectin-mediated platelet activation, with potential therapeutic targets identified.

Relieving platelet inhibition using a novel bi-specific antibody:A novel approach for circumventing the platelet storage lesion

This paper develops a bispecific antibody to enhance stored platelet reactivity by targeting PECAM-1, showing improved aggregation and thrombus formation in vitro.

Targeting von Willebrand factor selectively under inflammatory conditions

This study develops an assay to test drugs that inhibit von Willebrand factor selectively under oxidizing inflammatory conditions, finding lumacaftor may do so effectively.

Genetically determined platelet traits impact stroke risk through multiple mechanisms and cell types

This study identifies platelet traits as key risk factors for stroke using Mendelian Randomization and subclustering, revealing mechanisms involving platelet reactivity and endothelial cell adhesion.

Depletion of all platelet integrins impacts hemostasis, thrombosis and tumor metastasis

This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

Treatment with the ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis

The paper shows that CX-5461, a ribosome biogenesis inhibitor, increases platelet counts in humans and enhances megakaryopoiesis in mice without affecting platelet function or inflammatory cytokines.

Identification of a Novel Spliced Variant of ADAMTS13 in Human Mesenchymal Stem Cells

The paper identifies a novel alternatively spliced variant of ADAMTS13 in human mesenchymal stem cells with partial vWF cleavage activity.

Platelet-dependent clearance of uropathogenic Escherichia coli directly drives sepsis-induced thrombocytopenia in a mouse model

This study shows that platelets clear uropathogenic E. coli in a mouse model, leading to thrombocytopenia during sepsis.

Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis

This study develops a turbulence-assisted system to enhance iPSC-platelet production by regulating actin dynamics and mitochondrial inheritance.