Neuroinflammation and Neurodegeneration Mechanisms

MARK2 in glial cells suppresses inflammatory responses and mitigates tau toxicity

This study shows MARK2 in glial cells suppresses inflammation and reduces tau toxicity in neurodegenerative diseases.

Dysfunction of microglia-mediated synaptic pruning in Autism spectrum disorder

This study investigates how microglia-mediated synaptic pruning is disrupted in ASD by integrating inflammatory and synaptic signaling pathways, showing that reduced synaptic activity and pro-inflammatory activation lead to excessive synaptic accumulation.

Off-target effects of PLX5622 revealed: mixing microglial function in anesthesia and addiction withdrawal

This study reveals that PLX5622 affects anesthetic emergence and nicotine-withdrawal anxiety through enhanced drug metabolism, not microglial depletion.

Mild subcortical stroke induces widespread astrogliosis independent of microglia and age

The paper introduces a novel mouse model of mild subcortical stroke and shows that astrogliosis spreads widely and independently of microglia and age.

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

This study shows that PU.1 dosage regulates microglia maintenance in zebrafish and mammals through cell competition and apoptosis.

Astrocytic RIPK3 exerts protective anti-inflammatory activity during viral encephalitis via induction of serpin protease inhibitors.

This study shows that astrocytic RIPK3 reduces inflammation in viral encephalitis by increasing serpin protease inhibitors, improving survival and BBB integrity.

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived model

This study shows that SHIP1 regulates TREM2 signaling and macrophage functions in hiPSC-derived macrophages, affecting inflammation and phagocytosis.

Physiological and injury-induced microglial dynamics across the lifespan

This study examines microglial dynamics across different life stages, showing significant morphological and functional changes in response to injury.

Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function

This study shows that the CX3CR1-V249I variant in human microglia leads to dysfunctional phenotypes and affects neuronal growth and function.

Microglial GSDMD-Mediated Pyroptosis Drives Neuroinflammation in Parkinson's Disease

This study shows that microglial pyroptosis via the CASPASE-1/GSDMD pathway drives neuroinflammation and dopaminergic neuron loss in Parkinson's disease, suggesting GSDMD as a therapeutic target.

Structural Impact of Alzheimer's Disease Mutations on Transmembrane TREM2-DAP12 Interactions: An Atomistic Perspective

This study uses molecular dynamics simulations to analyze how TREM2 mutations affect the stability of the TREM2-DAP12 complex, revealing structural impacts on neuroimmune signaling in Alzheimer's disease.

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro

This study reprograms human macrophages in vitro using cytokines to mimic Alzheimer's disease-relevant phenotypes, showing transcriptomic and functional changes similar to disease-associated microglia.

Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders.

This paper investigates the molecular mechanisms of BEM, a non-antibiotic minocycline derivative, showing it retains therapeutic pleiotropy while losing antimicrobial activity, making it a potential treatment for neuroimmune and inflammatory disorders.

Discovery of an Achiral Small Molecule TREM2 Agonist with Im-proved Pharmacokinetic Profile and Validated Target Engagement

This paper describes the discovery of C1, an achiral TREM2 agonist with improved pharmacokinetics and validated target engagement compared to VG-3927.

Minocycline treatment affects astrocyte - microglia - neuron interaction and functional compensation of motor deficits in rat model of combined fluorocitrate and 6-OHDA lesion and early Parkinson's disease

This study investigates how minocycline affects astrocyte-microglia-neuron interactions and motor function recovery in a rat Parkinson's disease model.

The Potential Neuroinflammatory Attenuation Effects of Thymoquinone against 3, 4-Methylenedioxymethamphetamine-Induced Microglial Activation in BV2 Mouse Cell Line

This study examines the effects of thymoquinone on MDMA-induced microglial activation in BV2 cells, finding it reduces inflammatory gene expression and attenuates morphological changes.

Temporal shifts in microRNAs signify the inflammatory state of primary murine microglial cells

This study identifies miRNA expression changes in activated microglia, showing their role in inflammation and potential as biomarkers for neurodegenerative diseases.

Inhibition of Acyl-CoA: Cholesterol Acyltransferase 1 Promotes Shedding of Soluble TREM2 and LRP1-Dependent Phagocytosis of Amyloid β Protein in Microglia

This study shows ACAT1 inhibition increases microglial uptake of amyloid β via sTREM2 and LRP1, offering new therapeutic targets for Alzheimer's disease.

Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse

This study shows that preventing microglial reactivity protects against acute and progressive neurological dysfunction and motor impairments caused by alcohol abuse in mice.

Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer's Disease

This study identifies pathogen-specific microglial reprogramming by periodontal pathogens, linking virulence factors to Alzheimer's disease neuroinflammation.

Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus

This study identifies Apbb1ip as a genetic modulator of immune gene co-expression in aged mouse hippocampus, revealing age-related transcriptomic changes and immune response upregulation.

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation

This study uses brain organoids and assembloids with microglia to show region-specific microglial diversity and their response to SCN2A mutation-induced neuronal hyperactivity.

Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling

The paper identifies CD72 as a regulator of microglial tiling through proteomic profiling and functional assays.

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

KOLF2.1J iTF-Microglia: A standardized platform to studymicroglial transcriptional regulatory networks in CNS disease

The paper introduces a standardized iPSC-derived microglia model to study transcriptional regulatory networks in CNS diseases and identifies disease-associated genetic variants.

SUSTAINED SYSTEMIC AND NEUROINFLAMMATION IN COGNITIVE DYSFUNCTIONAL FEMALE MICE AFTER NON-SEVERE EXPERIMENTAL MALARIA

This study investigates cognitive dysfunction in female mice after non-severe experimental malaria, finding sustained systemic inflammation and glial cell changes linked to memory deficits.

Induction of hemodynamic traveling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging

The paper investigates hemodynamic traveling waves in a rat neuroinflammation model, showing their correlation with glial cell reactivity and implications for functional neuroimaging.

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

This study shows HDAC inhibition changes microglial activity and spatial distribution in stroke brains, promoting neuroprotection and recovery in mice.

Antibiotic-Induced Gut Dysbiosis Differentially Alters Hippocampal Glial Proliferation and Response After TMEV Infection

This study investigates how antibiotic-induced gut dysbiosis affects hippocampal glial responses and neuropathology after TMEV infection, showing region-specific effects and potential neuroprotective effects of CBZ.

TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

This study shows TRPV4 activation increases IL10 production in microglia, reducing inflammation by suppressing pro-inflammatory cytokines.