Neuroinflammation and Neurodegeneration Mechanisms

Neuroinflammation links the neurogenic and neurodegenerative phenotypes of Nrmt1-/- mice

This study shows that Nrmt1-/- mice exhibit premature aging and neurodegeneration linked to neuroinflammation due to impaired neurogenesis and lack of anti-inflammatory response.

IRF8 deficiency causes anxiety-like behavior in a sex-dependent manner

This study shows that IRF8 deficiency in microglia causes anxiety-like behavior in female mice but not males, with redox dysregulation involved.

Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

The human microglia responsome: a resource to better understand microglia states in health and disease

The paper characterizes the human microglia responsome by analyzing gene expression in microglia exposed to various stimuli, identifying distinct responses and genetic interactions relevant to disease.

Cerebellar white matter development is regulated by fractalkine-dependent microglia phagocytosis of oligodendrocyte progenitor cells

The paper shows that amoeboid microglia engulf oligodendrocyte progenitor cells in the developing cerebellum, with implications for neurodevelopmental disorders.

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

Modeling Stimulus-Induced Stress Responses in Microglia-like Cells Using a Commercial iPSC-dCas9-KRAB Line

The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.

Spatially Resolved Microglial Expression Around Aβ Plaques in Human Alzheimers Disease Tissue

The paper identifies gene expression changes in microglia around Aβ plaques in human Alzheimer's disease tissue and finds cross-species concordance with mouse data.

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

The paper develops a xenotransplantation model to study human microglia's processing of dying neurons, identifying a lipid-rich compartment called the gastrosome involved in neurodegeneration.

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the frontal cortex.

This study shows that dopaminergic signaling in adolescence affects microglial behavior and axonal plasticity in the frontal cortex, with potential therapeutic implications for adult brain plasticity.

Automated image segmentation uncovers the role of CD74high human microglia in cognitive decline

The paper uses automated image segmentation to identify CD74high microglia associated with cognitive decline in AD, linking transcriptomic and morphological features.

The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

This study identifies the flexible stalk domain of sTREM2 as critical for differential ligand binding and neuroprotection in Alzheimer's disease through molecular dynamics simulations.

The Microglial Trem2 R47H Alzheimer's Disease Risk Variant Does Not Detectably Alter Hippocampal Synaptic Transmission in Young Mice

This study investigates the effect of the Trem2 R47H variant on hippocampal synaptic transmission in young mice and finds no detectable changes in synaptic activity or density.

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron-microglia co-culture model

This paper develops a microfluidic co-culture model to study microglial synapse phagocytosis in AD, finding that APP microglia show enhanced synaptic uptake under inflammation.

Microglia regulate neuronal activity via structural remodeling of astrocytes

This study shows that microglia prune astrocytic processes in response to high-salt diet, leading to increased neuronal activity and hypertension.

Uncovering a new player in ischemic stroke: a study of intra-arterial interferon-gamma-producing monocytes in hyperacute stroke

This study identifies intra-arterial CD14+ monocytes as novel early sources of IFN-γ in hyperacute stroke, challenging the traditional view that adaptive immune cells are the main contributors.

Integrated QTL mapping and CRISPR screening in pooled iPSC-derived microglia reveals genetic drivers of neurodegenerative risk

The paper integrates QTL mapping and CRISPR screening in iPSC-derived microglia to identify genetic drivers of neurodegenerative risk by linking variants to phenotypes and gene expression.

Human aged astrocytes induce neurotoxicity in response to inflammatory stimuli

This study shows that aged human astrocytes are more neurotoxic than young ones when exposed to inflammatory stimuli, suggesting a link between aging and neurodegenerative diseases.

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

This study investigates how P2RY12 loss affects microglial metabolic and activation states, revealing altered metabolic pathways and increased susceptibility to ferroptosis.

CD11b Activation Reduces Myeloid Brain Infiltration and Mitigates Synucleinopathy in a Model of Parkinson's Disease

This study shows that CD11b agonism with LA1 reduces microglial activation and myeloid cell infiltration, thereby mitigating synucleinopathy in a Parkinson's disease model.

Protocol to isolate oligodendrocytes, microglia, endothelial cells, astrocytes, and neurons from a single mouse brain using magnetic-activated cell sorting

This paper describes a protocol for isolating five specific brain cell types from a single mouse brain using magnetic-activated cell sorting.

Defined human tri-lineage brain microtissues

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

CK2 inhibition suppresses glial inflammation in the brain

This study identifies CK2 as a key driver of glial inflammation in neurodegenerative disorders and shows that its inhibition reduces inflammation in AD models.

Microglia-to-neuron signaling increases lipid droplet metabolism, enhancing neuronal network activity

The paper investigates how microglia-to-neuron signaling via APOE4 affects neuronal network activity and lipid droplet metabolism during inflammation.

The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex.

This study investigates how P2Y12 loss affects microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex, finding region-specific roles for P2Y12 in injury response and plasticity.

FGA139, a Novel Cysteine Protease Inhibitor, Exhibits Anti-Inflammatory and Neuroprotective Activity and Reveals Microglial Modulation via Multi-Omics Profiling

This paper identifies FGA139 as a novel cysteine protease inhibitor with anti-inflammatory and neuroprotective effects, showing it modulates microglial activation through multi-omics profiling.

Systematic analysis of cellular crosstalk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

Age-associated microglia populations identified from several single cell transcriptome data

The paper identifies common and dataset-specific age-associated microglia populations across mouse and human datasets using integrative single-cell transcriptomic analysis.

Photoreceptor loss does not recruit neutrophils despite strong microglial activation

This study shows that microglia activate in response to photoreceptor loss in the retina, but neutrophils are not recruited despite their proximity to blood vessels.