B. Chen

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

This study identifies two distinct mechanisms by which the intrinsically disordered cytoplasmic tail of HPO-30 regulates actin dynamics during dendrite branching in C. elegans.

Structures reveal a key mechanism of WAVE Regulatory Complex activation by Rac1 GTPase

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Salicin modifies osteoarthritis progression by binding on IRE1α and inhibiting IRE1α mediated endoplasmic reticulum stress

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Novel Murine models of Mania and Depression

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

Dynamic changes of gut microbiota associated with blood glucose levels in sows from pregnancy through lactation

This study examines how restricted feeding during gestation affects blood glucose levels and gut microbiota in sows across pregnancy and lactation stages.

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

Sensory convergence in the world s largest cavefish diversification: patterns of neuromast evolution, distribution and associated behaviour in Sinocyclocheilus

This study examines neuromast evolution and distribution in Sinocyclocheilus cavefish, finding asymmetry and convergence in cave-adapted species with distinct wall-following behaviours.

Non-canonical Function of a Hif-1α Splice Variant Contributes to the Sustained Flight of Locusts

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors

This study shows MTG16 regulates colonic epithelial differentiation and tumorigenesis by repressing E protein transcription factors in mice and links its expression to IBD.

Drought restricted sucrose transport from outer cottonseed coat to fiber and further inhibited cellulose synthesis during cotton fiber thickening

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

Differential antibody dynamics to SARS-CoV-2 infection and vaccination

This study compares antibody durability and breadth after SARS-CoV-2 infection and vaccination, finding that infection-induced antibodies show greater long-term stability and cross-variant breadth.

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

A genotype independent DMP-HI system in dicot crops

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

Transient nuclear deformation primes epigenetic state and promotes cell reprogramming

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

Mega- and meta-analyses of fecal metagenomic studies assessing response to immune checkpoint inhibitors

The paper performs meta- and mega-analyses of fecal metagenomic data from four cohorts to identify bacterial species associated with response to immune checkpoint inhibitors.

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

SUFFICIENT ACTIVITY OF THE UBIQUITIN PROTEASOME SYSTEM IN AGED MICE AND DURING RETINAL DEGENERATION SUPPORTS DHFR-BASED CONDITIONAL CONTROL OF PROTEIN ABUNDANCE IN THE RETINA

This study evaluates the effectiveness of a DHFR-based system for conditional protein control in aged and retinal degeneration mouse models, showing successful degradation despite compromised UPS in some models.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.

aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis

This study identifies a novel β-arrestin-2-mediated signaling pathway that mediates aPC/PAR1's anti-apoptotic effects in endothelial cells.