C. Ye

Visualization of SARS-CoV-2 infection dynamic

This study develops a method to visualize SARS-CoV-2 infection dynamics using reporter-expressing recombinant viruses, enabling real-time tracking and antibody screening in vivo.

Molecular basis for kinin selectivity and activation of the human bradykinin receptors

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.

Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy

This study compares the pathogenicity and immune response of SARS-CoV-2 variants B.1.1.7 and B.1.351 with WA-1 in mice, showing reduced protection from convalescent plasma against the variants.

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 hACE2 transgenic mice

This study identifies ORF3a and ORF6 as key contributors to SARS-CoV-2 pathogenesis in mice using a reverse genetics system and K18 hACE2 transgenic mice.

Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells

This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

This paper generates and characterizes recombinant SARS-CoV-2 viruses expressing fluorescent or bioluminescent reporter genes, demonstrating their utility for tracking viral infection and screening therapeutics.

A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2

This study uses zebrafish models to replicate SARS-CoV-2-induced olfactory and cardiovascular effects, showing drug treatment can reverse some symptoms.

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

Ambroxol and Ciprofloxacin Show Activity Against SARS-CoV2 in Vero E6 Cells at Clinically-Relevant Concentrations

The paper tests drug activity against SARS-CoV-2 in Vero E6 cells and finds ambroxol and ciprofloxacin effective at clinically relevant concentrations.

Rescue of SARS-CoV-2 from a single bacterial artificial chromosome

The paper develops an infectious SARS-CoV-2 cDNA clone using a bacterial artificial chromosome, which replicates similarly to the natural virus in cell cultures and animal models.

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

This paper describes a rapid and reproducible plaque reduction microneutralization assay for identifying neutralizing antibodies and antivirals against SARS-CoV-2, suitable for high-throughput screening.

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

Establishment of a stable transgenic g6pdM1315-1443 zebrafish line with glucose-6-phosphate dehydrogenase deficiency

The paper establishes a zebrafish model of G6PD deficiency that replicates key clinical features observed in humans with the condition.

Remdesivir inhibits renal fibrosis in obstructed kidneys

This study shows remdesivir reduces renal fibrosis in obstructed kidneys without affecting renal or liver function.

An engineered Abcb4 expressing model reveals the central role of NF-κB in the regulation of drug resistance in zebrafish

This study creates a zebrafish model expressing Abcb4 to investigate drug resistance mechanisms, finding that NF-κB plays a central role in regulating Abcb4-mediated resistance.

A broad and potent H1-specific human monoclonal antibody produced in plants prevents influenza virus infection and transmission in guinea pigs

This paper produces a human monoclonal antibody against H1N1 influenza in plants and shows it prevents infection and transmission in guinea pigs, similar to mammalian-produced versions.

Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance

This study characterizes carbapenem-resistant Klebsiella pneumoniae isolates, identifying ST11 as the main type and blaKPC-2 as the dominant carbapenemase gene.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

The intestinal microbiota induces daily metabolic rhythms and controls lipid uptake through the enzyme histone deacetylase 3.

Beyond a ribosomal RNA methyltransferase, the wider role of MraW in DNA methylation, motility and colonization in Escherichia coli O157:H7

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

Generation and Selection of a Panel of Pan-Filovirus Single-Chain Antibodies using Cell-Free Ribosome Display

The paper generates and selects pan-filovirus single-chain antibodies using cell-free ribosome display, identifying two scFvs that detect all known filovirus species.

ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157

This study identifies ADAM17 as the primary sheddase for TREM2 ectodomain release and determines the cleavage site at histidine 157.