P. Chen

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

lncRNA-RMST functioned as a SOX2 transcription co-regulator to regulate miR-1251 in the progression of Hirschsprung's disease

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

CRISPR/Cpf1 mediated genome editing enhances Bombyx mori resistance to BmNPV

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Mass-spectrometry-based near complete draft of the Saccharomyces cerevisiae proteome

The paper presents a near-complete yeast proteome dataset using optimized sample preparation and high-resolution mass spectrometry, identifying 5610 proteins with 94.1% coverage of yeast ORFs.

Single cell reconstruction of human basal cell diversity in normal and IPF lung.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.

Immobilization, Direct Electrochemistry and Electrocatalysis of Hemoglobin on Peptide-Carbon Nanotube Modified Electrode

This paper develops a biosensor for hydrogen peroxide using hemoglobin immobilized on a peptide-carbon nanotube modified electrode, showing enhanced electrochemical response and direct electron transfer.

Annexina2 as a target protein for chlorogenic acid in human lung cancer A549 cells

This study identifies annexin A2 as a target protein of chlorogenic acid in A549 cells, showing it inhibits tumor proliferation by suppressing NF-κB downstream anti-apoptotic genes.

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells

This study shows that depletion of FOXA1/2 in human liver cells reprograms differentiation state and metabolism, promoting de-differentiation and pluripotency.

Prohibitin protects against cigarette smoke extract-induced cell apoptosis in cultured human pulmonary microvascular endothelial cells

This study shows prohibitin protects human pulmonary microvascular endothelial cells from cigarette smoke extract-induced apoptosis by preserving mitochondrial function and reducing oxidative stress.

β-alanine or L-carnosine prevents the development of pale, soft and exudative pork by inhibiting the glycolysis of porcine longissimus dorsi muscle

The paper investigates how β-alanine and L-carnosine affect pork quality by modulating glycolysis and AMPK activity in porcine muscle.

Male accessory gland factors increased sex pheromone titres in the glands of Spodoptera litura female moths by inhibiting calling behavior

Differences in Activation of Intracellular Signalling in Primary Human Retinal Endothelial Cells Between Isoforms of VEGFA-165.

This study compares the activation of MAPK and AKT signaling pathways by VEGFA165a and VEGFA165b in primary human retinal endothelial cells, finding stronger activation by VEGFA165a at lower doses.

Juvenile hormone regulation on the flight capability of Bactrocera dorsalis (Diptera: Tephritidae)

This study investigates how juvenile hormone (JH) regulates flight capability in Bactrocera dorsalis, finding that JH levels correlate with flight duration and distance, and that JH III treatment enhances flight performance.

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.

Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1

This study shows that breast tumor-associated metalloproteases cleave reovirus σ1 protein, reducing infectivity, and demonstrates that a σ1 mutation can overcome this inactivation.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal

The paper identifies an inflammatory CD4 T cell subset and transcriptomic signatures in JIA patients in remission that predict relapse after anti-TNFα withdrawal.

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

Mechanical stress compromises multicomponent efflux complexes in bacteria

The paper shows mechanical stress, specifically shear stress, disrupts the CusCBA efflux complex in E. coli, increasing metal toxicity susceptibility.

LonP1 Orchestrates UPRmt and UPRER and Mitochondrial Dynamics to Regulate Heart Function

This study shows LonP1 regulates UPRmt and UPRER, and mitochondrial dynamics in cardiomyocytes, impacting heart function and revealing potential therapeutic targets for heart failure.

Cytoplasmic volume and limiting nucleoplasmin scale nuclear size during Xenopus laevis development

Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats

The paper uses mathematical modeling to show that adaptive immunity significantly reduces RSV titer in cotton rats, with key kinetic features observed in both in vitro and in vivo experiments.