T. Wang

A novel architecture of PT neuron-based corticothalamic connectivity in the auditory system

The paper reveals a fully-connected corticothalamic architecture in the auditory system, showing L5 neurons project broadly to thalamic modules, challenging traditional hierarchical models.

A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

Circulating metabolites of Borneolum syntheticum (Bingpian) inhibit foam-cell formation in macrophages induced by oxidized low-density lipoprotein

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

RNA structures and dynamics with A resolution revealed by x-ray free electron lasers

This paper reveals RNA structures and dynamics at near-atomic resolution using x-ray free electron lasers, showing how RNA folds through intermediate states and forms triplexes.

D614G and Omicron SARS-CoV-2 variant spike proteins differ in the effects of N-glycan modifications on spike expression, virus infectivity, and neutralization by some therapeutic antibodies

This study compares how N-glycan modifications affect spike expression, infectivity, and antibody neutralization in SARS-CoV-2 D614G and Omicron variants.

GATA3 ZnF2-defective mutant condensation underlies type I IFN-activating in breast cancer

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL

This study uses iPSC-derived neurovascular cells to show impaired BBB function and disrupted tight junctions in CADASIL, highlighting early neurovascular interaction defects.

Designer DNA NanoGripper

The paper designs, synthesizes, and characterizes a DNA nanorobot, NanoGripper, capable of capturing viral particles and functioning as a biosensor for SARS-CoV-2 detection in human saliva.

Alpha Synuclein Modulates Mitochondrial Ca2+ Uptake from ER During Cell Stimulation and Under Stress Conditions

This study shows alpha synuclein modulates mitochondrial Ca2+ uptake from ER during stimulation and stress, with distinct roles for its N-terminal and C-terminal regions.

IL-15 priming alters IFN-γ regulation in murine NK cells

This study shows that IL-15 priming changes IFN-γ regulation in murine NK cells by altering transcriptional responses to activating receptor stimulation.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Data-driven prediction of colonization outcomes for complex microbial communities

The paper predicts colonization outcomes of exogenous microbes in complex communities using a data-driven approach, validated with synthetic data and experimental tests.

A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity

Structural Adaptation of Fungal Cell Wall in Hypersaline Environment

This study uses solid-state NMR to analyze the cell wall structure of Aspergillus sydowii under varying salinity conditions, revealing structural adaptations that enhance survival in hypersaline environments.

Feasibility in MacArthur's Consumer-Resource Model

This paper identifies conditions for feasibility in MacArthur's consumer-resource model and shows how system complexity and resource growth affect feasibility.

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

Predicting metabolomic profiles from microbial composition through neural ordinary differential equations

This paper introduces mNODE, a neural ODE-based method predicting metabolomic profiles from microbial composition, showing superior performance and interpretability across human and environmental microbiomes.

Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs

The paper identifies a canine mammary tumor subtype that molecularly resembles human basal-like breast cancer, suggesting it as a potential translational model.

Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform

This study evaluates immune responses to an ISFV-based Zika vaccine, showing neutralizing antibodies and T-cells contribute to protection.

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases in extracellular matrix abnormalities

This paper develops a human iPSC model of COL4A1/A2 small vessel disease, showing that MMP inhibition rescues ECM abnormalities and mural cell defects.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Lower shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.