Schizophrenia research and treatment

Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum

The paper investigates neural correlates of reward-cognition interactions and apathy in the psychosis continuum using fMRI and clinical scores.

Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia

This study integrates GWAS and exome data with single-cell gene expression to show common and ultra-rare schizophrenia variants are enriched in brain-expressed, selection-sensitive genes.

Relapse prevention through health technology program reduces hospitalization in schizophrenia

A technology-enhanced relapse prevention program reduced hospitalization days by 4 days compared to usual care in schizophrenia patients.

High-frequency changes in single-trial visual evoked potentials for unattended stimuli in chronic schizophrenia

This study detects high-frequency changes in single-trial visual evoked potentials in chronic schizophrenia using spectral and statistical analyses of EEG data.

Genome-wide tandem repeat expansions contribute to schizophrenia risk

The paper identifies genome-wide rare tandem repeat expansions associated with schizophrenia risk by comparing cases and controls.

Brain-Specific Deletion of GIT1 Impairs Cognition and Alters Phosphorylation of Synaptic Protein Networks Implicated in Schizophrenia Susceptibility

This study shows that deleting GIT1 in the brain impairs cognition and disrupts phosphorylation networks of synaptic proteins linked to schizophrenia and neurodevelopmental disorders.

Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

This study investigates how muscarinic acetylcholine and dopamine receptor function affect auditory mismatch negativity (MMN) in schizophrenia, finding differential sensitivity to these neuromodulators.

Association of VEGF and KDR polymorphisms with the development of schizophrenia

The paper investigates the association between VEGF and KDR gene polymorphisms and schizophrenia risk in Tunisian population, finding significant SNPs linked to subtypes and symptomatology.

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

This study examines EEG abnormalities in Grin2a and Akap11 mutant mice, finding similarities with schizophrenia patients, suggesting these mutants as models for the disorder.

Convergent and non-additive impact of schizophrenia risk genes in human neurons

This study shows that schizophrenia risk genes have convergent and non-additive transcriptomic effects when perturbed together in human neurons, suggesting functional redundancy and complex interactions.

Longitudinal allometry of sulcal morphology in health and schizophrenia

The paper examines longitudinal allometric scaling of sulcal morphology in health and schizophrenia, finding steeper age-related declines in SZ compared to healthy individuals.

Differential sphingosine-1-phosphate receptor-1 protein expression in the dorsolateral prefrontal cortex between schizophrenia Type 1 and Type 2

The paper compares S1PR1 protein expression in schizophrenia subtypes using postmortem brain tissue and suggests its potential as an in vivo PET biomarker.

Erbb4 deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes

This study shows that deleting Erbb4 from PV+ interneurons in mice leads to neuroimaging changes similar to those seen in psychosis patients.

Enrichment of somatic mutations in schizophrenia brain targets prenatally active transcription factor bindings sites

The paper identifies prenatal mutational processes in schizophrenia brains linked to transcription factor binding sites and proposes a new term 'skiagenesis' for these mutations.

Leveraging genetics to improve Body Mass Index increase prediction in the first-episode of psychosis

This study uses polygenic risk scores to predict BMI increase in first-episode psychosis patients, finding shared genetic variants between schizophrenia and BMI contribute significantly to the prediction.

Glycine attenuates impairments of stimulus-evokedgamma oscillation in the ketaminemodel of schizophrenia

This study examines if glycine improves negative symptoms in the ketamine model of schizophrenia by modulating auditory evoked gamma-band responses.

Converging pathways found in copy number variation syndromes with high schizophrenia risk

This study identifies common molecular pathways associated with schizophrenia risk in copy number variation syndromes by analyzing gene interactions and pathways from multiple databases.

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

The paper identifies electrophysiological measures in hiPSC-derived neurons linked to schizophrenia diagnosis and cognitive performance.

Rare schizophrenia risk variant burden is conserved in diverse human populations

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

Sex differences in the human brain transcriptome of cases with schizophrenia

This study examines sex differences in schizophrenia gene expression using RNA-seq data from 437 controls and 341 cases, finding small effect sizes and reproducible signatures involving X/Y-linked genes and synaptic pathways.

The processing of semantic complexity and co-speech gestures in schizophrenia: a naturalistic, multimodal fMRI study

This study investigates how schizophrenia affects neural processing of semantically complex speech and co-speech gestures using a naturalistic multimodal fMRI paradigm, finding reduced activation in patients for complex segments, which is mitigated by gestures.

Multiple genes in cis mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neurons

The paper identifies multiple genes in cis regulated by a chromatin accessibility variant that contribute to synaptic dysfunction in human neurons associated with schizophrenia.

Over-Representation of Potential SP4 Target Genes within Schizophrenia-Risk Genes

The paper identifies SP4 as a schizophrenia-risk gene and shows its role in regulating other risk genes through GC-boxes in their promoters.

Atypically larger variability of resource allocation accounts for visual working memory deficits in schizophrenia

This study shows that schizophrenia patients have larger variability in memory resource allocation, not reduced capacity, explaining their visual working memory deficits.

GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

This study examines GABAA and NMDA receptor density changes in MAM-treated rats and their behavioral correlates, finding reduced 5GABAAR and increased NMDA receptor densities linked to schizophrenia-like behaviors.

Pharmacological impacts on schizophrenia functional analysis: a postmortem proteome study.

This study analyzes the proteomic changes in schizophrenia using postmortem brain samples and shows how antipsychotic drugs modulate these changes across multiple biological levels.

Behavioral phenotyping of Zip8 393T-KI mice for in vivo study of schizophrenia pathogenesis

The paper establishes a Zip8 393T-knock-in mouse model and reports baseline behavioral and anatomical findings, showing subtle cognitive defects in male homozygous mice but no major differences from wild-type.