Alzheimer's disease research and treatments

Amyloid-beta deposition and reduced drainage at the cribriform plate lymphatics in APP/PS1 mouse model of Alzheimer's Disease

This study shows that in 24-month-old APP/PS1 mice, cribriform plate lymphatics have reduced CSF efflux and A{beta} accumulation, along with inflammation and lymphatic atrophy.

Potassium homeostasis during disease progression of Alzheimers Disease

This study shows that astrocytic K+ clearance is reduced in the hippocampus of symptomatic 5xFAD mice, correlating with decreased Kir4.1 channel expression and altered neuronal signaling.

Heritability of Alzheimer-related plasma biomarkers in the Amish population

The paper estimates heritability of Alzheimer-related plasma biomarkers in the Amish population, finding moderate genetic contributions to biomarker variances.

Cryo-EM evidence for a common factor in Alzheimer's and other neurodegenerations

The paper uses cryo-EM maps to identify a common molecular factor in neurodegenerative diseases, suggesting RNA as a potential candidate.

Independent Generation of Amyloid-β via Novel APP Transcripts

The paper identifies novel APP transcripts that generate Aβ independently of β-secretase, showing their expression and presence in CSF.

sKL/mKL Transcript Ratio and Protein Localization Define a Species- and Region-Specific Klotho Signature in the CNS and AD Progression

The paper examines s-KL/m-KL transcript ratio and protein localization in the CNS and their association with AD progression across species.

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome

The paper uses a network diffusion model to analyze how genetic factors and brain connectivity influence selective vulnerability or resilience to Alzheimer's tauopathy.

Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease

This study shows that anti-amyloid beta therapy improves stroke recovery in the presence of cerebral amyloid beta accumulation by resolving myeloid immunity impairment.

Transcriptomic analysis reveals new reparative mechanisms of SCF and GCSF - reduced neuropathology in aged APPPS1 mice

This study identifies molecular mechanisms by which SCF+G-CSF reduces AD pathology in aged APP/PS1 mice through transcriptomic analysis of differentially expressed genes and pathway modulation.

Mapping the Structural Landscape of Amyloid Fibrils to Guide Polymorph-Specific Therapeutics

This paper introduces FibrilSite, a computational pipeline to identify structural features of amyloid fibrils, revealing conserved and polymorph-specific sites that guide drug discovery.

APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease

This study performs APOE-stratified GWAS to uncover genetic mechanisms underlying Alzheimer's disease risk and response to therapies.

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide

This paper demonstrates that the QBP1 peptide effectively inhibits hIAPP aggregation and protects β-cells from amyloid-induced toxicity in vitro.

MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies

Discovery of SMCs that correct MAPT splicing, reduce 4R tau, and rescue pathology in patient-derived neuronal and in vivo models of 4R tauopathies.

Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone

This study uses quantitative 3D histochemistry to show that netoglitazone reduces amyloid-beta plaques in specific brain regions of a mouse AD model.

Pharmacological restoration of deficits in mitochondrial trafficking rescues aberrant axonal activity in tauopathy

This study shows that restoring mitochondrial trafficking in tauopathy rescues presynaptic dysfunction and axonal activity.

Alzheimer's Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

This study uses vascularized neuroimmune organoids to model sporadic Alzheimer's disease and test drug efficacy.

Target the Heart: a new axis of Alzheimer's disease prevention

The paper identifies heart medications that may prevent or reduce Alzheimer's disease pathology by inhibiting the calcineurin-NFAT pathway, with synergistic effects when combined with cyclosporine A.

Directionality bias underpinsdivergent spatiotemporalprogression of Alzheimer-relatedtauopathy in mouse models

This study shows that directional bias in tau transmission along fiber tracts explains divergent spatiotemporal progression of tauopathies in mouse models.

Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men

The paper examines sex-specific effects of anxiety on cognition and neural networks in mice and humans, finding earlier cognitive decline in female AD mice and faster dementia progression in anxious female humans.

Alzheimer's disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming

This study identifies Wwox as a protective factor against Alzheimer's disease by modulating metabolic pathways and reducing amyloid pathology in a Drosophila model.

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset

The paper provides a whole-genome sequencing dataset of 36,361 ADSP participants, including variant annotations, phenotypes, and a linkage disequilibrium panel for Alzheimer's Disease research.

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer's disease

The paper identifies sex-dependent impairments in parvalbumin interneurons in the retrosplenial cortex as a cause of cognitive deficits in Alzheimer's disease and suggests targeting these neurons as a therapeutic strategy.

13C tracing in synaptosomes reveals that SGLT2 inhibition with dapagliflozin prevents metabolic deficits in the 5X-FAD model of Alzheimer's Disease

Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer's disease

This study identifies axonal enlargement linked to amyloidosis, lysosome destabilization, and hemorrhage as a key pathological feature in Alzheimer's disease.

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimers Disease with Psychosis

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer's disease

The paper examines immune changes in early Alzheimer's disease stages, finding altered T cell reactivity to β-amyloid-related antigens in preclinical AD and MCI.

Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

The paper investigates how caspase cleavage of APP contributes to Aβ-induced synaptic dysfunction and spine loss in neurons.

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

This study identifies age-related calcium signaling dysregulation in macaque entorhinal cortex linked to early tau hyperphosphorylation, suggesting a mechanism for Alzheimer's disease initiation.

Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model

This study identifies Neu1 and PPCA as regulators of APP metabolism in Alzheimer's disease, showing their therapeutic potential in reducing amyloid pathology.