Epilepsy research and treatment

Exploring the Role of MMP9 and its Interaction with TGFβ Signalling in Patients with Mesial Temporal Lobe Epilepsy-Hippocampal Sclerosis

This study investigates the role of MMP9 and TGFβ signalling in MTLE-HS patients, finding increased MMP9 expression and activity, reduced ZO1, and enhanced TGFβ signalling in astrocytes.

Prominent contributions of selective neuronal subtypes to pediatric drug-resistant focal dysplasia

The paper identifies specific neuronal subtypes in pediatric FCD that show significant transcriptomic alterations linked to drug-resistant epilepsy and suggests potential therapeutic targets.

Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures

This paper evaluates an artificial bridge that restores hippocampal loop function in an in vitro model of limbic seizures, reducing ictal activity and restoring connectivity.

SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.

MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favorable outcomes

This study identifies ZFHX3 variants as a cause of childhood partial epilepsy and infantile spasms, with favorable treatment outcomes and insights into the developmental expression pattern of the gene.

N-acetylcysteine and acetyl-L-carnitine did not prevent acute PTZ-induced seizure in adult and larvae zebrafish

This study tests N-acetylcysteine and acetyl-L-carnitine for preventing PTZ-induced seizures in zebrafish but finds no effect, while diazepam shows efficacy.

Semaphorin 4D induced inhibitory synaptogenesis restores benzodiazepine sensitivity in a mouse model of Status Epilepticus

This study shows that Sema4D treatment reduces seizure susceptibility and restores benzodiazepine sensitivity in a mouse model of Status Epilepticus.

Controlling Neocortical Epileptic Seizures using Forced TemporalSpike-Time Stimulation: An In Silico Computational Study

This paper optimizes a neurostimulation protocol to desynchronize pathological neuronal firing patterns during and after epileptic seizures using a computational model.

Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy

The paper investigates the relationship between sleep spindles and treatment response in epileptic encephalopathy, finding that increased spindles correlate with cognitive improvement after diazepam treatment.

Natural language processing and expert follow-up establishes tachycardia association with CDKL5 deficiency disorder

The paper uses natural language processing and phenome-wide analysis to identify tachycardia as a significant comorbidity in CDKL5 deficiency disorder.

GluK2 is a target for gene therapy in drug-resistant Temporal Lobe Epilepsy

This study demonstrates that gene therapy targeting GluK2 reduces seizures in TLE models and patient-derived slices.

Effect of Dual Leucine Zipper Kinase Inhibitor GNE-3511 on Epileptogenesis and Cognitive and Behavioral Changes in a Temporal Lobe Epilepsy Model in Mice

This study investigates the effect of DLK inhibitor GNE-3511 on epilepsy and cognitive deficits in a mouse model, finding reduced seizures, anxiety, and neuronal loss.

Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

Sex and estrous cycle stage shape left-right asymmetry in chronic hippocampal seizures in mice

This study shows that in mice, female-specific left-right asymmetry in hippocampal function interacts with estrous cycle stage to influence chronic seizure patterns following kainic acid injection.

Chemogenetic approaches reveal dual functions of microglia in epilepsy

This study uses chemogenetic manipulation to show that microglia have both seizure-reducing and seizure-promoting effects in a mouse epilepsy model.

Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala

This study identifies increased chondroitin sulfate proteoglycans (CSPGs) in the hippocampus and amygdala as a cause of infection-induced epilepsy, showing their role in neuronal hyperexcitability and potential as a therapeutic target.

Multisite Thalamic Recordings to Characterize Seizure Propagation in the Human Brain

This study uses multisite thalamic recordings to show that seizure propagation in TLE involves thalamic regions beyond the ANT, with pulvinar involvement being more prominent in 60% of patients.

Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense model for Dravet syndrome

This paper introduces a novel Dravet syndrome mouse model with a Scn1a R613X nonsense mutation, showing seizures, premature death, and hyperactivity.

Characterisation and automated quantification of induced seizure-related behaviours in Xenopus laevis tadpoles

This study characterizes and automatically quantifies seizure-related behaviors in Xenopus laevis tadpoles using chemical induction and video analysis software.

Phenotypic screening using waveform analysis of calcium dynamics in primary cortical cultures

This paper develops a high-throughput screening system for analyzing calcium waveform features in neurons to characterize anti-epileptic drugs and predict their mechanisms of action.

Evaluating the interplay between estrous cyclicity and induced seizure susceptibility in Scn2aK1422E mice

This study evaluates how the estrous cycle affects seizure susceptibility in Scn2aK1422E mice and finds no significant association, but notes disrupted estrous cyclicity in untreated females.

Transient receptor potential melastatin 4 (TRPM4) regulates hilar mossy cell loss in temporal lobe epilepsy

This study identifies TRPM4 as a contributor to mossy cell death in temporal lobe epilepsy following status epilepticus, affecting seizure susceptibility and memory deficits.

Dysregulation of GABAergic System in the Hippocampus and Inferior Colliculi of Rats during the Development of Audiogenic Epilepsy

This study examines GABAergic system changes in KM rats during audiogenic epilepsy development, finding altered transporter expression and GABAergic activity in the hippocampus and inferior colliculi at different developmental stages.

Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy

This study shows that a mutation in DNM1 causes epilepsy by disrupting synaptic vesicle endocytosis, and that a drug can reverse these effects in a mouse model.

Modelling human KCNT1-epilepsy in Drosophila: a seizure phenotype and drug responses

This study models human KCNT1-epilepsy in Drosophila by expressing patient mutations and shows drug responses, demonstrating the utility of Drosophila as a model for assessing treatments.

Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy

The paper identifies cell loss and subtype-specific vulnerability of interneurons in the subiculum of a mouse model for mesial temporal lobe epilepsy.

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.

Microglial IL-1β plays a protective role in epilepsy

This paper reviews the role of microglial IL-1β in epilepsy, highlighting its protective function and potential therapeutic implications.