Neurogenesis and neuroplasticity mechanisms

Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels

The paper identifies two neurogenic pathways, dNG-ETd and iNG-ETi, that differentially shape the organization and diversification of cortical output channels in mice.

A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical Development

The paper compiles a large transcriptomic dataset of neocortical development and uses joint matrix decomposition to identify conserved transcriptome dynamics across mammals and developmental stages.

Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains

This study shows that NEUROG2 can reprogram human microglial lineage cells into neurons both in vitro and in vivo, revealing a new pathway for neuronal replacement.

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

The paper shows human-specific enhancer HAR1984 promotes neurogenesis by altering chromatin interactions and gene regulation in cortical organoids and mice.

ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron development

This study identifies ARHGEF6's role in forebrain interneuron development across species, showing its impact on migration, survival, and circuit formation.

Ventricular Forebrain Organoids Reproduce Macroscale Geometry of the Developing Telencephalon

This study develops a method to generate forebrain organoids with macroscale geometry resembling the developing telencephalon, showing enlarged ventricles and delayed maturation in human compared to mouse.

Fluoxetine for Prenatal Alcohol-Exposed Mice: Addressing Impaired Enrichment-Mediated Neurogenesis

This study examines whether fluoxetine restores impaired enriched environment-mediated neurogenesis in prenatal alcohol-exposed mice, finding no restoration in enriched environments but increased neurogenesis in standard housing.

Phosphorylation and DNA Damage Resolution Coordinate SOX2-Mediated Reprogramming in vivo

This study shows that SOX2 phosphorylation and the PRKDC-dependent NHEJ pathway are essential for in vivo glia-to-neuron reprogramming, with p53 knockdown restoring reprogramming in PRKDC-deficient mice.

Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribute to the superficial dorsal horn and lamina V

The paper identifies the origin and migration patterns of specific neurons in the dorsal horn, showing that Reln+Lmx1b+ and Dab1+Lmx1b+ neurons derive from dI5 or dILB neurons and contribute to different laminae.

Reconstitution of the Spinal Cord Injury Microenvironment in Adult Neural Stem Cell-Derived Organoids

This paper introduces neuroids, a modular organoid system that mimics the adult spinal cord injury microenvironment to study NSC differentiation and gliogenic bias.

Ex vivo astrocyte-to-oligodendrocyte conversion in human adult cortical tissue using transcription factor overexpression

This study demonstrates that overexpressing OLIG2 and SOX10 in human astrocytes converts them into oligodendrocytes ex vivo, preserving brain architecture and showing potential for myelin repair in MS.

Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations

The paper measures Notch3 signaling in zebrafish adult neural stem cells and shows it correlates with quiescence and stemness, with jagged1b promoting stemness through lateral induction.

The RNA and protein landscapes of mouse brain organoids

This study characterizes the RNA and protein landscapes of mouse brain organoids, showing they closely resemble neonatal mouse brains and express synaptic proteins after three weeks of development.

Development of a Humanized Mouse Model for Studying adult Spinal Cord myelination, remyelination and Drug Efficacy

This paper develops a humanized mouse model to study human oligodendrocyte maturation, remyelination, and drug efficacy in spinal cord injury.

Cajal-Retzius fate specification is disrupted by constitutive activation of β-Catenin in hem progenitors

This study shows that constitutive β-Catenin activation in cortical hem progenitors disrupts CR cell identity by preventing the Tbr2+ stage.

Delayed forebrain excitatory and inhibitory neurogenesis inSTRADA-related megalencephaly via mTOR hyperactivity

This study shows that mTOR hyperactivity in STRADA-deficient brain organoids causes delayed neurogenesis and altered interneuron fate, which can be rescued by rapamycin.

The bipolar-to-multipolar transition of dendrite extension of cerebellar granule neurons requires MTCL2 to link the Golgi apparatus to the microtubule cage.

This study shows MTCL2 links the Golgi to microtubules in cerebellar granule neurons, enabling the bipolar-to-multipolar transition of dendrite extension.

Independent control of neurogenesis and dorsoventral patterning by NKX2-2

The paper identifies how NKX2-2 independently controls neurogenesis and dorsoventral patterning in human spinal progenitors through distinct mechanisms from rodents.

Transient activation of potent progenitor cells is required for spinal cord regeneration

This study identifies sox2+ progenitors as critical for zebrafish spinal cord regeneration and shows Bach1 transcription factors regulate their activation and quiescence.

Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration

This paper shows that Prox1 acts as a mitotic bookmark in mouse hippocampal neural stem cells to preserve neuronal lineage identity by promoting H3K27me3 restoration.

Spinal cord regeneration deploys adult molecular programs that do not recapitulate embryonic development

The paper examines whether spinal cord regeneration in adult zebrafish recapitulates embryonic development by analyzing single-cell RNA-seq data across development, homeostasis, and regeneration.

Premyelinating Oligodendrocyte Survival Governs CNS Remyelination

This study shows that premyelinating oligodendrocyte survival affects oligodendrocyte production rates, with increased survival promoting regeneration after demyelination and decreased survival contributing to age-related decline.

Development and Characterization of Self-Tracing Neural Progenitor Cells for Mapping Their Synaptic Integration into Endogenous Neural Networks

This paper develops self-tracing neural progenitor cells that express trans-synaptic tracers to trace integration into host neural networks in vitro and in vivo.

Intercellular Transfer of PTBP1 Drives Human Neural Stem Cell Fate

This study identifies PTBP1's role in human neural stem cell fate by showing it can be transferred between cells via tunneling nanotubes and extracellular vesicles, affecting proliferation and differentiation.

p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's Disease

This study shows that p75NTR regulates adult hippocampal neurogenesis in Alzheimer's disease, with its deletion worsening neurogenic deficits in mouse models and human iPSC-derived cells.

Coordinated neural progenitor adaptations drive primate neocortical downscaling

The paper identifies coordinated adaptations in neural progenitor cells that drive neocortical downscaling in marmosets compared to humans.

Opioid Modulation of Differential Gene Expression and Neuronal Differentiation in the Ventricular-Subventricular Zone of Adult Male Zebra Finches

The paper investigates how opioid modulation affects gene expression and neuronal differentiation in the V-SVZ of adult male zebra finches using microarray and qPCR analyses.

Intellectual disability risk gene RFX4 regulates cortical neurogenesis by restraining neuronal differentiation

This study identifies RFX4's role in cortical development by showing it restrains neurogenesis and regulates synaptic gene expression, with distinct effects from haploinsufficiency.

Mechanical impact on neural stem cell lineage decisions in human brain organoids

This study shows that mechanical forces influence neural stem cell lineage decisions in human brain organoids through changes in molecular programs and cellular metabolism.

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age

This study shows that OPCs in aging retain remyelination potential, which can be reactivated by demyelination, improving myelin repair.