Neurogenesis and neuroplasticity mechanisms

Pten Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

Inward thickening of embryonic neuron-packing brain walls: Mechanical integrity via curvature-associated inner-surface contractility

The paper investigates how the embryonic brain wall thickens inward through inner-surface contractility, showing that actomyosin-mediated contraction is essential for this process.

Mtor/Rptor Function Globally Prevents Cortical Microcephaly and Cell-autonomously Promotes Postnatal Neuron Survival in Cell Type Specific Manner

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

Lipid transport is necessary for neocortical lamination

The paper investigates BLTP1's role in neocortical lamination by analyzing patients and mouse models, finding lipid transport defects cause structural brain abnormalities.

Untangling mechanisms for cerebellar neural specification using human pluripotent stem cell-derived organoids

This study uses human pluripotent stem cell-derived cerebellar organoids to investigate human cerebellar development and disease-related gene expression.

L-serine diet restores impaired adult neurogenesis in the hippocampus of 3xTg-AD mice

This study shows that a L-serine-enriched diet improves adult neurogenesis in 3xTg-AD mice without affecting amyloidosis.

Temporal Interference Stimulation Enhances Neural Regeneration

This study shows that temporal interference stimulation enhances neural progenitor cell maturation in vitro and promotes hippocampal neurogenesis in a mouse Alzheimer's model.

Cell-state mapping reveals a reversible neuroblast accumulation in the aging mouse hippocampus

The paper identifies a reversible apoptotic checkpoint in aging mouse hippocampal neuroblasts that limits neurogenesis and can be mitigated by voluntary running.

PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential

This study shows that PIEZO1 and PIEZO2 channels in oligodendrocytes regulate sheath formation, expansion, and myelination by detecting mechanical cues.

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

Mesenchymal predominance in olfactory epithelium-derived cultures limits modeling of neurodevelopmental brain disorders

This study shows that human olfactory epithelium cultures are mostly mesenchymal cells, not neurogenic, limiting their use for modeling neurodevelopmental disorders.

Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation

The paper shows quiescent neural stem cells temporarily express neuronal genes to coordinate reactivation during CNS development.

Evolutionary origins and transcriptomic innovations of vertebrate Cajal-Retzius cells

This study investigates the evolutionary origins of Cajal-Retzius cells across vertebrates, finding they are conserved but gained specific transcriptomic features in amniotes.

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

This study identifies the role of the Asp protein in symmetrically dividing neural precursors, showing its necessity for brain growth and development in a fly model of microcephaly.

Uncoupling Neocortical Neuron Fate and Migration via a Let-7-RBX2 Axis

This study shows let-7 microRNA regulates both neuronal fate and migration in the neocortex through distinct pathways involving RBX2 and CRL5.

The dentate gyrus grows throughout life despite turnover of developmentally-born neurons

The paper quantifies neuronal birth and loss in the rat dentate gyrus across adulthood, finding that neurogenesis contributes to growth but is offset by neuronal turnover.

Songbird connectome reveals tunneling of migratory neurons in the adult striatum

The paper uses connectomics to show that migrating neurons in the adult zebra finch striatum physically reshape mature circuits by creating tunnels through synapse-rich regions.

Temporal Profiling of Upper-Layer Neurons Reveals Changes in the Molecular Landscape Upon Maternal Immune Activation

This study maps the molecular changes in murine upper-layer cortical neurons during development and shows how maternal immune activation disrupts this process through post-transcriptional and signaling mechanisms.

Morphogenetic Patterning During Regional and Cell Type Specification in the Embryonic Basal Ganglia

The paper presents a model of dynamic spatial and temporal patterning in the embryonic basal ganglia, showing how progenitor movement and transcriptional changes lead to diverse neuronal subtypes.

Serotonergic innervation and cortical progenitor regulation in human brain assembloids

This study uses human brain assembloids to show serotonergic innervation influences cortical progenitor states and proliferation during development.

A defined 2D system for generating and expanding human basal radial glia from iPSCs

This study develops a 2D system to generate human basal radial glia from iPSCs, showing they exhibit key molecular and functional features of native cells.

Temporal Requirement for Stearoyl-CoA Desaturase 1 in Oligodendrocyte Development but Not Myelin Maintenance

This study shows that Scd1 is required for oligodendrocyte development and myelination but not for maintaining mature myelin.

Insulinoma-associated 1 promotes neurogenic proliferation of cortical basal progenitors but is largely dispensable for projection neuron production

The paper shows INSM1 is essential for basal progenitor cell-cycle progression but not their generation, with apical progenitors compensating for reduced neuron production.

GLIS3 is a key regulator of astrocyte differentiation in human neural stem cells

This study identifies GLIS3 as a critical regulator of astrocyte differentiation from human neural stem cells, showing its role in gene expression and potential therapeutic relevance.

Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer's disease model mice

The paper shows that iPaD treatment and Prkag2 knockdown enhance neurogenesis and reduce amyloid-β in Alzheimer's disease model mice by activating AMP kinase signaling.

Psi represses EGFR signalling in the neural stem cell niche to inhibit neuroblast proliferation in the Drosophila brain

The paper shows that Psi in Drosophila cortex glia represses EGFR signaling to prevent NSC overproliferation, highlighting intrinsic and extrinsic control mechanisms in stem cell fate.

MicroRNAs are required within a critical time window to define neural patterning during early human brain development

The paper shows miRNAs are essential during a specific time window for proper neural patterning in human brain development, with disruption causing defects in forebrain identity.

Synthetic lumen rounding directs neural progenitor division mode

This study shows that altering lumen shape in human brain organoids affects apical progenitor division orientation and lineage progression.

Enhancing Adult Neurogenesis Rescues Hippocampal Cognitive Functions in an Alzheimer's Mouse Model

This study shows enhancing adult hippocampal neurogenesis in Alzheimer's mice improves spatial navigation and exploratory behavior.

Distinct signaling center and progenitor identity dynamics initiate human forebrain patterning

The paper identifies human-specific features of telencephalic patterning in early development using single-cell transcriptomics and spatial imaging, showing delayed ventral SHH signaling and enhanced anterior FGF signaling compared to mice.