Neurogenesis and neuroplasticity mechanisms

MIF overexpression upon SARS-CoV-2 infection induces neural regeneration in human-derived brain organoids

This study shows that MIF overexpression after SARS-CoV-2 infection promotes neural regeneration in human brain organoids through EGFR signaling and self-upregulation.

Lineage origin of spinal cord cell type diversity

This study traces the lineage of spinal cord progenitors in mice to show that individual progenitors can generate diverse neuron and astrocyte types, challenging the idea of fixed progenitor identities.

Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive Oligodendrocyte Lineage

The paper investigates the mechanisms of selective cortical myelination, finding that early myelination is axon-driven and influenced by interactions with specific neuronal partners.

Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period

This study shows that loss of estradiol and progesterone in female rats at 9 months of age reduces neurogenesis and behavioral function, earlier than age-related declines at 14 months.

Diverging routes of oligodendrocyte recruitment in adaptive and regenerative myelination

This study compares oligodendrocyte recruitment in adaptive and regenerative myelination using zebrafish, showing distinct transcriptional programs and Gpr17-dependent pathways.

COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION

The paper shows that reversing age-related changes in oligodendrocyte-derived extracellular matrix improves cognition in aged mice.

Traumatic brain injury has a lasting impact on hippocampal neurogenesis and Notch1 is involved in regulating this injury response

This study investigates how traumatic brain injury affects hippocampal neurogenesis and shows that Notch1 regulates this response by influencing neural stem cell proliferation and differentiation.

Ploidy and neuron size impact nervous system development and function in Xenopus

This study investigates how ploidy and neuron size affect nervous system development and function in Xenopus by analyzing triploid tadpoles and their physiological and behavioral differences.

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profiles

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

Functional recruitment of astrocyte-derived neurons into the mouse visual cortex

This study shows that astrocytes can be converted into functional neurons in the mouse visual cortex, which can integrate into cortical circuits and respond to visual stimuli.

Ca2+-mediated protein citrullination regulates proliferation in the regenerating and malignant CNS

This paper identifies Ca2+-mediated protein citrullination as a regulator of neural stem cell proliferation in CNS regeneration and cancer, showing PAD inhibitors suppress medulloblastoma growth.

Pre-myelinating oligodendrocyte ADGRG1 is required for axon ensheathment and CNS myelin formation

This study identifies ADGRG1 as a key regulator of pre-myelinating oligodendrocyte development and axon ensheathment, showing its role in CNS myelin formation through RhoA activation.

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

This study generates corticospinal-like neurons from SOX6+/NG2+ cortical progenitors using a multi-component transcriptional construct, achieving high fidelity in morphology, molecular, transcriptomic, and electrophysiological characteristics.

Distinct epigenetic and metabolic states reflect the regional identity of adult neural stem cells and prime their fate

This study identifies niche-specific chromatin and metabolic states in adult mouse neural stem cells that influence their neuronal fate potential.

Human basal radial glia morphotypes are transcriptionally distinct and exhibit different cell fate determination

The paper identifies transcriptionally distinct morphotypes of human basal radial glia and links their morphology, gene expression, and cell fate.

Molecular and Cellular Underpinnings of Spatial Heterogeneity in Fetal Cortical Folding

This study maps gene expression patterns to cortical folding features in fetal brains, identifying molecular mechanisms and linking them to autism risk genes.

MEIS1 is Required for Establishing Bergmann Glia-Specific Properties in the Developing Cerebellum

This study identifies MEIS1 as a key transcription factor required for the development of Bergmann glia-specific properties in the cerebellum by regulating the expression of BG-specific genes.

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate

The paper identifies transcription factors and effector genes involved in human cortical neurogenesis using CRISPRi screening in a primary culture system.

Cell-cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells

This study shows that cell cycle progression and cytokinesis are required for the early-to-late gene expression transition in Drosophila NSCs, alongside hormonal cues.

Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization

The paper shows that birthdate aligns vestibular sensory neurons with central and motor partners in a gaze stabilization circuit through a spatiotemporal 'first-come, first-served' mechanism.

ZC4H2 loss of function is associated with temporal dysregulation of neural stem proliferation and neuron development

This study shows that ZC4H2 loss of function in human neural stem cells and organoids leads to premature neuronal differentiation and impaired neurogenesis, with potential therapeutic restoration through a codon-optimized transgene.

A Latent Activated Olfactory Stem Cell State Revealed by Single Cell Transcriptomic and Epigenomic Profiling

This study identifies a latent activated stem cell state in olfactory epithelium using single-cell transcriptomic and epigenomic profiling during injury-induced regeneration.

Ontogeny of the spinal cord dorsal horn

This paper investigates how the dorsal horn of the spinal cord develops, showing that neurons are diversified by time and spatial-molecular gradients, leading to the formation of laminae.

Internalization of exogenous myelin by oligodendroglia promotes lineage progression

This study shows that oligodendrocytes internalize exogenous myelin, enhancing their proliferation and differentiation through transcriptional changes and lipid droplet formation.

Cross-fostering affects microglia and cell death in the hippocampus of female and male degu pups

This study examines how cross-fostering impacts hippocampal microglia and cell death in degu pups, showing reduced cell death but no effect on dentate gyrus volume or immature neuron density.

Gsx2 Regulates Oligodendrocyte Precursor Formation in the Zebrafish Spinal Cord

This study identifies Gsx2 as a regulator of oligodendrocyte precursor cell formation in zebrafish spinal cord through single-cell and single-nuclei multi-omics analyses.

Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells

The paper identifies a synaptic gene program in human oligodendrocyte precursor cells (OPCs) using single-cell RNA sequencing, revealing distinct embryonic and adult subsets with synaptic-related gene expression.

Dlx2 reprograms the transcriptome and laminar position of glia-derivedAscl1-induced interneurons

This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.